Proteros Biostructures Newsletter: April 2024
Excellence is our main asset
Excellence in project execution is fundamental - we deliver what we promise. We reach the milestones, meet timelines and agreed budgets. Our expertise warrants the design of scientifically relevant experiments that ultimately reach the RIGHT outcomes.
JAK1 Case Study: Kick-start your SBDD program with the RIGHT protein structure.
Proteros' state-of-the-art protein production sciences facility coupled with highly skilled crystallography expertise all under one roof is a game changer for drug discovery. Explore a remarkable case study where Proteros scientists worked with AstraZeneca's R&D team to precisely express and unravel the co-crystal structure of AstraZeneca's JAK1 inhibitors. Delve deeper into the remarkable journey of this program, witnessing how our team at Proteros unveiled the crystal structure and supported AstraZeneca's medicinal chemistry team in launching a structure-based drug design initiative. Get in touch to uncover how our team can not only decipher the structures of your most complex targets, but also how to identify and characterize innovative qualified hits.
Proteros Gallery Structures Highlight: RIPK2
Receptor-interacting serine/threonine-protein kinase 2 plays an essential role in modulation of innate and adaptive immune responses. The availability of multiple co-crystal structures of RIPK2 in complex with either type I or type II kinase inhibitors enables virtual screen and design of RIPK2 inhibitors with novel chemical scaffolds. PROTAC approach have demonstrated outstanding efficacy in preclinical models. (also see our cryo-EM services) Crystal system (kinase domain) is established to generate Protein-Ligand structures at 2.5 ? resolution.
Upcoming Events
Drug Discovery Chemistry (DDC)
We are excited to be part of the upcoming Drug Discovery Chemistry conference in San Diego from April 1st to 4th. Join Brantley Haigh , Debora Konz Makino Ph.D, Eva Cunha, PhD , and Dr. Andreas Schmitt, as they delve into how we are assisting global biotech and pharma companies with their early-stage discovery initiatives.
If you would like to explore how our proficiency in structural biology and drug discovery can propel you towards your next breakthrough, don't hesitate to get in touch with Brantley Haigh while the team is on the West Coast!
Our Services
DISCOVERY SOLUTIONS
We serve as our client's innovative catalyst, leveraging our cutting-edge technology platform and expert knowledge to drive novel solutions in drug discovery.
X-RAY CRYSTALLOGRAPHY
Elucidation of even the most complex structures through the preparation of the RIGHT protein.
ASSAYS, BIOPHYSICS & SCREENING
Our diverse range of services includes both pre-established and tailor-made assay development solutions designed specifically for profiling and screening applications.
领英推荐
BIOLOGICS
Your "one-stop-shop" solution for complex biologics / antigen purification with biochemical, biophysical and structural characterization.
CRYO-EM
Cutting edge Cryo-EM technology platform to deliver the RIGHT challenging proteins and complexes.
PROTEIN SCIENCES
At the heart of everything we do is the RIGHT protein for the right experiment. We ensure all proteins have the necessary unique characteristics to ensure your programs success.
PROVEN TRACK RECORD AT PROTEROS
+6,000 Structures elucidated
+10,000 Projects completed
300 Peer-reviewed publications
Cutting Edge Facilities to Foster Excellence
Located in the thriving Martinsried / Munich - Biotech Cluster in Germany, our cutting-edge facility has been meticulously designed to cater to our specific service execution demands. Each specialized area, including Structural Biology, Cryo-EM, Protein Sciences, Biologics, Biophysics and Screening, has dedicated floors and lab rooms. We have created an environment where all these disciplines coexist under one roof, fostering the seamless collaboration and synergistic interaction necessary for the success of Discovery Solutions and multi-disciplinary projects.
Copyright ? 2024 Proteros Biostructures GmbH
Mailing address:
EUROPE
Tel: +49 (0)89/700761-0 Fax: +49 (0)89/700761-115 Email: [email protected]
Headquarters: Proteros biostructures GmbH Bunsenstr. 7a D - 82152 Martinsried Germany Get directions
NORTH AMERICA
Tel: +1-213-924-1483 Email: [email protected]
Headquarters: Proteros USA Inc. One Broadway, 14th Floor Cambridge, MA 02142 United States Get directions