Prime Editing A Step Beyond CRISPR
In our latest post, we talk about Prime Editing, a revolutionary technique in genetic editing that surpasses the limitations of CRISPR/Cas9. Prime Editing offers unprecedented precision in correcting defective genes and making complex changes to DNA.
Its applications range from correcting genetic diseases to creating disease models for research. This tool promises to advance our understanding of genetics and the development of more effective gene therapies. Read the full blog post HERE.
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What is gene editing and how does it work?
Gene editing enables scientists to alter the sequence of genes by adding, replacing, or removing certain DNA segments. In this article we explore the main gene editing technologies, including Zinc-finger nucleases (ZFNs) and transcription-activator–like effector nucleases (TALENs) and the CRISPR/Cas system.
CRISPR: the genetic scissors
CRISPR/Cas9 technology is a molecular tool used for “editing” or “correcting” the genome of any cell, including human cells. It would be like genetic scissors able to cut any DNA molecule in a very precise and fully controlled way. This ability to cut DNA is what allows its sequence to be modified, removing or inserting new DNA. In this post, we are going to see how classic CRISPR editing come about and works.
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ZeClinics' team of expert scientists can tailor our zebrafish Tol2 transgenesis services to address your unique research objectives. Using the Tol2 transgenesis system, we can insert large cargo or expression cassettes (like transcriptional reporters, coding sequences of human genes, fluorescent reporters, sensors to test environmental changes) under the control of a promoter of interest. This strategy is often used for tissue-specific reporter expression or to overexpress mutant proteins.
ZeClinics is at the forefront of genetic engineering, leveraging the groundbreaking CRISPR Cas9 gene editing technique. We excel in delivering highly accurate and efficient zebrafish CRISPR knockout solutions for precise gene editing. Utilizing cutting-edge CRISPR Cas9 technology, we ensure reliable genetic modifications in zebrafish. Our expert scientists offer comprehensive support throughout the entire process, from sgRNA design, to the generation and validation of zebrafish knockout mutants.
ZeClinics' zebrafish Crispants are a fast-track choice for screening loss-of-function alleles, and validating functional genetic models before committing to building a stable line. The Crispant approach provides early proof-of-concept or viability testing of your gene knockout model in as little as one month. Our zebrafish Crispants will enable you to reduce costs, time and animal use in your gene knockout projects.
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