POCT featured products assisting in diagnosis of heart failure

01

The growing burden of heart failure

Heart failure (HF) is a group of clinical syndromes caused by abnormalities in cardiac structure and/or function leading to impaired ventricular filling and/or ejection capacity. Heart failure can be divided into chronic heart failure (CHF) and acute heart failure (AHF) according to the time and speed of its occurrence.

Heart failure is the terminal stage of various heart diseases and is characterized by high morbidity, mortality, hospitalization rates, poor patient quality of life, and high medical costs. According to the occurrence and development process of heart failure, it can be divided into 4 stages: stage A is the risk stage of heart failure, stage B is the pre-heart failure stage, stage C is the symptomatic heart failure stage, and stage D is the advanced stage of heart failure [1].

02

The best marker of heart failure--BNP/NTproBNP

The natriuretic peptide family is a group of peptides with similar structures but different origins, including atrial natriuretic peptide (ANP, type A), brain natriuretic peptide (BNP, type B) and C-type natriuretic peptide (CNP, C-type).

BNP and NT-proBNP (N-terminal B-type natriuretic peptide precursor) in the natriuretic peptide family are currently routinely carried out by clinical laboratory departments. They have the highest recommended category among all biomarkers for heart failure and has now become the most important biomarker for the identification, diagnosis and prognosis evaluation of high-risk groups of heart failure [4]. Overall, the clinical application value of BNP and NT-proBNP in patients with heart failure is equivalent. Clinicians should choose to test BNP or NT-proBNP according to the different conditions of the patient.

For patients with acute chest pain or dyspnea, BNP or NT-proBNP should be detected to rule out the possibility of heart failure. When BNP <100 ng/L and NT-proBNP <300 ng/L, the possibility of acute heart failure can usually be ruled out; while when BNP <35 ng/L and NT-proBNP <125 ng/L, the possibility of chronic heart failure can be ruled out [ 5].

03

Diagreat Biotech Heart Failure--NT-proBNP Rapid Test Solution

Diagreat Biotech's?N-terminal pro-B-type Natriuretic Peptide Determination Kit (Fluorescence Immunochromatographic Assay) is one of the rapid test products of Diagreat’s myocardial marker series and is suitable for patients with suspected heart failure and acute chest pain. Only 20 μL of serum or plasma sample is needed to achieve rapid, precise and quantitative detection of NT-proBNP in patients, with results available in 20 minutes .?

For people at high risk of heart failure, this test can be performed and corresponding intervention can be carried out to prevent or delay the occurrence of heart failure. For patients with suspected heart failure, this test can enable early treatment and improve prognosis. NT-proBNP testing can also be used to guide heart failure treatment.