PIM1 Inhibitors for the Treatment of Viral Infection
Knowledge Transfer Office, City University of Hong Kong
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Viral infections cause a number of severe diseases threatening human health. EV-A71 is an RNA virus which mainly causes infection of HFMD, and in some cases could cause neurological diseases. Since 2008, large HFMD epidemics have posed an ongoing threat to public health in China, resulting in hundreds of deaths in 2012 alone. Zika virus outbreaks have occurred worldwide, leading to immune system dysfunction in adults and severe symptoms in fetuses and infants.?
Despite their widespread effects, there are currently limited effective treatments or methods of control for viral infections such as those causing HFMD and Zika virus disease.?
Therefore, better understanding on the biological mechanism that causes viral infections for the development of adequate therapeutic interventions for the treatment of viral infections are urgently required. PIM1 is an enzyme mainly involved in cell survival pathways and it is known to involve in human diseases including cancer and inflammatory disorders, but the correlation between PIM1 and viral infections is limited.?
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