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Novo Nordisk announces $2.3bn investment to expand production site in France: Novo Nordisk has said it will be investing more than $2.3bn to expand its existing production site in France "for the current and future product portfolio within serious chronic diseases”. Read

‘Treasure trove’ of new CRISPR systems holds promise for genome editing: CRISPR–Cas9 is best known as a laboratory tool for editing DNA, but its natural function is as part of the immune system that helps microorganisms to fight off viruses. Now, researchers have used an algorithm to sort through millions of genomes to find new, rare types of CRISPR system that could eventually be adapted into genome-editing tools. Read

Follow-up study finds supplementing preterm infants with DHA has no effect on neurodevelopment: Research led by the University of Adelaide, Australia, has found that supplementing infants born at less than 29 weeks gestation with docosahexaenoic acid (DHA) has no impact on behavioral functioning later in life. Read

How Church and Langer Make the Impossible Possible: The laboratories of George Church, PhD, professor of genetics at Harvard Medical School, and Robert Langer, the David H. Koch Institute Professor, Massachusetts Institute of Technology, are legendary for their ability to spin out biopharma companies and entrepreneurs. Read

The next frontier in immunotherapy? CAR-Macrophages as a novel cancer treatment strategy: Immunotherapy has revolutionized cancer treatment, offering promising avenues beyond traditional methods. Recent breakthroughs showcased at the Society for Immunotherapy of Cancer’s (SITC) annual meeting have spotlighted innovative approaches, notably?chimeric antigen receptor macrophage (CAR-M) therapy, offering new strategies in the fight against solid tumors and addressing the limitations of current treatments. Read

Camouflaging stem cell-derived transplants to avoid immune rejection: Cell and organ transplants can be lifesaving, but patients often encounter long waiting lists due to the shortage of suitable donors. According to donatelife, in 2021, 6,000 people died in the U.S. alone while waiting for a transplant. Read

NVIDIA Collaborates With Genentech to Accelerate Drug Discovery Using Generative AI: Genentech and NVIDIA's collaboration is revolutionizing drug discovery and development with generative AI. By integrating generative AI into its lab in a loop iterative framework, Genentech is making strides in bridging the gap between lab experiments and computational algorithms. View Video

Don't press 'pandemic panic button' scientists caution on China pneumonia report: Leading scientists urged caution over fears of another pandemic on Thursday after the World Health Organization requested more?information?from China on a rise of respiratory illnesses and pneumonia clusters among children."We have to be careful," said Marion Koopmans, a Dutch virologist who advised the WHO on COVID-19. "We really need more information, particularly diagnostic information." Read

Boehringer Ingelheim to acquire T3 Pharmaceuticals in deal worth over $500m: Boehringer Ingelheim has said it will be acquiring bacterial cancer therapy specialist T3 Pharmaceuticals in a deal worth over $500m, marking a significant boost to its immuno-oncology portfolio. Read

New drug shows potential in treatment of cutaneous squamous cell carcinoma: A study conducted at the University of Turku, Finland, shows that plixorafenib, a new drug developed for treating melanoma and lung cancer, may also stop the progression of cutaneous squamous cell carcinoma. Read

Digital Therapeutic Clinical Trials - A Pioneering Approach to Better Treatments: Exciting Insights from the World of Digital Therapeutics and Decentralized Clinical Trials! In a recent discussion with Joel Morse of Curavit and Andy Molnar of Digital Therapeutics Alliance, we explore the innovative strides in digital therapeutic clinical trials. Read

New Clinical Trial Insights - Co-administration of Seasonal Influenza Vaccine and COVID-19 Vaccines: Read

An Amazing Clinical Step Towards Treating Multiple System Atrophy (MSA): MSA is a rare disorder, which gradually damages cells in the brain, affecting movement & balance, and autonomic nervous function. Read

How digital twins may enable personalised health treatment: Ever wondered about a future where your #health is understood, tested, and treated through a digital replica of yourself? Scientists are paving the way for just that. Imagine having a digital twin, a computational model based on your genes, proteins, cells, and entire body system, all intertwined with your personal health data.?Read

Merck to acquire Caraway Therapeutics in a deal worth up to $610m: Merck & Co – known as MSD outside the US and Canada – has entered into a definitive agreement to acquire Caraway Therapeutics, with the deal worth up to $610m.The acquisition gives Merck access to the preclinical biopharma’s pipeline of small-molecule therapeutics for genetically defined neurodegenerative and rare diseases. Read

Using human stem cells to model a severe epilepsy syndrome and identify a potential targeted treatment: Mutations in the SCN3A gene cause a spectrum of neurological conditions collectively referred to as SCN3A-related neurodevelopmental disorders, which includes different types of epilepsy and brain malformations. Read

European Patent Office declares Moderna mRNA patent invalid: The European Patent Office declared a contested mRNA patent owned by Moderna?invalid, the office said on Tuesday, handing a win to BioNTech?and its partner Pfizer?(PFE.N)?in a patent dispute between the two coronavirus vaccine makers. Read

Clinical trial results give new hope for children with rare gliomas: A collaboration of researchers, led by UCL and Great Ormond Street Hospital, have published successful results from a Phase II clinical trial for the treatment of BRAF mutated low-grade pediatric gliomas. Gliomas are cancerous brain tumors that start in glial cells—the supporting cells of the brain. Read

Lab-grown blood vessels could potentially treat strokes and vascular dementia: Scientists from the University of Cambridge’s Victor Phillip Dahdaleh Heart and Lung Research Institute have grown small blood vessel models in labs to potentially treat major causes of stroke and vascular dementia. Read

AstraZeneca announces launch of new healthtech business Evinova to optimise clinical trials: AstraZeneca (AZ) has announced the launch of its new health-technology business, Evinova, to accelerate innovation across the life sciences sector and the delivery of clinical trials and better health outcomes. Read

Scientists discover new Achilles heel of leukemia cells: Leukemia is the most common type of cancer in children. Treatment involves intensive chemotherapy, which has severe side effects due to its non-specific mode of action. Read

Pfizer and Astellas’ Xtandi approved by FDA for earlier prostate cancer indication: Pfizer and Astellas’ Xtandi (enzalutamide) has been approved by the US Food and Drug Administration (FDA) to treat non-metastatic castration-sensitive prostate cancer (nmCSPC) patients with biochemical recurrence (BCR) and a high risk of metastasis. Read

Revolutionary AI Approach Uses Satellite Imaging for Personalized Cancer Treatment: In a groundbreaking study, researchers at Karolinska Institutet and SciLifeLab have developed an innovative #artificial intelligence (#AI ) approach, NIPMAP, to analyze #tumor tissues. Read

FDA approves, the first and only, DefenCath to reduce the misery of catheter-related bloodstream infections: It is well known that Hemodialysis is a standard procedure used?in Patients with renal failure / compromised renal function. The central venous catheters (CVCs) involved in this procedure often have a high risk of CRBSIs. CRBSI is one of the most frequent, deadly, and expensive complications of CVCs and possibly the most well-known reason for nosocomial bacteremia. Read

Newly Developed mRNA Vaccine Protects Against Lyme Disease: A lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA vaccine that encodes the outer surface protein A (OspA) from B. burgdorferi. Read

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