Pharmaceutical Therapy in Cancer- Advances

Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach to treating many types of cancer. In RPT, radiation is systemically or locally delivered using pharmaceuticals that either bind preferentially to cancer cells or accumulate by physiological mechanisms.

Almost all radionuclides used in RPT emit photons that can be imaged, enabling non-invasive visualization of the biodistribution of the therapeutic agent.

Compared with almost all other systemic cancer treatment options, RPT has shown efficacy with minimal toxicity. With the recent FDA approval of several RPT agents, the remarkable potential of this treatment is now being recognized.?

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The mechanism of action for RPT is radiation-induced killing of cells. Investigation into the effects of radiation on tissues and tumours began soon after the discovery of radiation and radioactivity. RPT has the benefit of drawing on the substantial knowledge base of radiotherapy. However, RPT differs from radiotherapy, and it is important to understand how those elements unique to RPT influence therapy.

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