The Path of Innovation: Linking Nobel Prize Discoveries in microRNA with EIIP-Based Biological Advances
Veljko Veljkovic
Researcher @ Biomed Protection | Drug Discovery, Research Skills, Electronic Biology, Bioinformatics
Two scientists, Victor Ambros and Gary Ruvkun, were awarded the Nobel Prize in Physiology or Medicine on Monday for their groundbreaking discovery of microRNA.
The analysis of microRNA is crucial for understanding gene regulation, as it significantly influences gene expression, impacting numerous biological processes and the development of various diseases. Different approaches for analyzing microRNA have been developed using the molecular descriptor electron-ion interaction potential (EIIP), with examples available in references 1-5.
Discovered 50 years ago, EIIP is a simple physical parameter that depends solely on atomic numbers and has been applied to a wide range of biological phenomena, including functional mapping of DNA/RNA and protein sequences, protein-protein interactions, assessing the biological effects of mutations, de novo protein design, viral evolution, and drug and vaccine development. More than 300 selected EIIP-based articles from PubMed, as well as patents—including those related to microRNA and other noncoding RNA analysis—can be found on the Electronic Biology website: https://electronicbiology.org/.
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