?? Paper of the day
Prashant Nasa
ICU Physician - Co-editor: Rational use of IV Fluids in Critically ill (link in bio)- PROVE Network - Delphi Methodology - Fluid and Oxygen are Drugs - X: @drnasap
Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock
Published in Annals of Intensive Care
Summary:
This article investigates the association between disseminated intravascular coagulation (DIC) and acute kidney injury (AKI) in patients with septic shock. The study found that DIC is strongly associated with a higher risk of developing severe AKI and requiring renal replacement therapy, even after adjusting for severity and other relevant factors.
Key takeaways:
1?? DIC occurrence is strongly associated with a threefold increased risk of developing the more severe stage of AKI (KDIGO3) and requiring renal replacement therapy.
2?? Patients with DIC had a higher mortality rate and a higher frequency of AKI, particularly the more severe stages of AKI.
3?? After adjustment for confounding factors, DIC remained significantly associated with the risk of AKI severity and the need for renal replacement therapy.
Counter arguments:
1. The association between DIC and AKI occurrence was no longer significant after adjusting for confounding factors.
2. DIC occurrence was not associated with MAKE criteria (a composite endpoint for Major Adverse Kidney Event) at the end of the hospital stay after multivariate analysis.