?? Paper of the day
Prashant Nasa
Intensivist-Anaesthesiologist II Editor: Rational use of IV Fluids in Critically ll PROVE Network -Delphi Methodology II Fluid and Oxygen are Drugs
Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial
Published in JAMA
Summary:
The SUSTAIN CSX Randomized Clinical Trial investigated the effect of high-dose selenium supplementation on postoperative organ dysfunction and mortality in cardiac surgery patients. The study concluded that high-dose intravenous sodium selenite did not reduce morbidity or mortality in high-risk cardiac surgery patients.
Key takeaways:
1. The study found that high-dose selenium supplementation did not increase the number of persistent organ dysfunction-free and alive days over the first 30 postoperative days.
2. There was no significant difference in the 30-day mortality rates between the selenium and placebo groups.
3. The findings do not support the routine perioperative use of selenium for patients undergoing cardiac surgery.
Counter arguments:
1. The study did not support the expected benefits of high-dose selenium supplementation in reducing postoperative organ dysfunction and mortality.
2. While selenium has documented antioxidative and immunomodulatory effects, the study did not find any significant improvement in patient outcomes after cardiac surgery.