?? Paper of the day
Prashant Nasa
ICU Physician - Co-editor: Rational use of IV Fluids in Critically ill (link in bio)- PROVE Network - Delphi Methodology - Fluid and Oxygen are Drugs - X: @drnasap
????BEST II–RCT: Blood pressure management after Endovascular Therapy for Acute Ischemic Stroke.
Published in JAMA: https://jamanetwork.com/journals/jama/article-abstract/2808995
??Summary:
This article discusses an RCT that evaluated the effectiveness of lower systolic blood pressure (SBP) targets after successful endovascular therapy for acute ischemic stroke.
The study aimed to determine if SBP targets of less than 140 mm Hg or less than 160 mm Hg were harmful or futile compared to the guideline-recommended target of 180 mm Hg or less.
?? Takeaways:
1?? Lower SBP targets after successful endovascular therapy for acute ischemic stroke did not meet the criteria for futility.
2?? The study did not find evidence of harm with SBP targets of less than 140 mm Hg or less than 160 mm Hg.
3?? The predicted probability of success in a future larger trial was low (25% for an SBP target of less than 140 mm Hg and 14% for an SBP target of less than 160 mm Hg)
??Limitations:
1. The study sample size was relatively small (120 participants), which may limit the generalizability of the findings.
2. The study only evaluated the short-term effects of lower SBP targets, and the long-term effects are still unknown.
3. The study did not assess the impact of lower SBP targets on specific patient subgroups, such as those with comorbidities or older age.