OtoRhinoLaryngology New Articles February 16th,2015
Vascularisation of the geniculate ganglion
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 1 λεπτ?Folia Morphologica Vascularisation of the geniculate ganglion A. Do?i?, M. ?etkovi?, S. Marinkovi?, D. Mitrovi?, M. Gruji?i?, M. Mi?ovi?, M. Milisavljevi? ·Thursday, February 12, 2015, 1:13 *Background:* Lack of the relevant data in the literature and possible clinical significance of the geniculate ganglion vasculature inspired us to examine the vessels of this ganglion. *Materials and methods:* Twelve temporal bones were taken during autopsy and microdissected. Four geniculate ganglions were taken as well, serially sectioned and used for haematoxylin-eosin and trichrome staining, and... περισσ?τερα ?
Variations in the squamous part of the occipital bone
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 1 λεπτ?Folia Morphologica Variations in the squamous part of the occipital bone in medieval and contemporary cranial series from Bulgaria S. Nikolova, D. Toneva, Y. Yordanov, N. Lazarov · Thursday, February 12, 2015, 1:13 The squamous part of the occipital bone is a place of many different variations. They are a result of faulty ossification in the occipital squama or due to the presence of sutural bones in the lambda region. As their differentiation is intricate because of the various criteria used, the issue of their recognition in the adult skull still remains difficult even though they ... περισσ?τερα ?
Palatine bones
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 3 δευτερ?λεπταFolia Morphologica Sex determination based on the analysis of a contemporary Polish population’s palatine bones: a computed tomography study of 1,200 patients I. M. Tomaszewska, P. Fr?czek, M. Gomulska, M. Pliczko, A. ?liwińska, K. Sa?apa, R. Chrzan, P. Kowalski, M. Nowakowski, J. A. Walocha · Thursday, February 12, 2015, 1:13 *Background:* The aims of the present study were to assess whether the hard palate reveals any measurable sex-related differences, and to create a mathematical model which would differentiate between males and females using hard palate measurements alone. *Mater... περισσ?τερα ?
Thyroid benign lymphoepithelial lesions
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 3 δευτερ?λεπταFolia Morphologica Thyroid lymphoepithelial nodule A. Handra-luca, E. Dragoescu · Thursday, February 12, 2015, 1:13 Thyroid benign lymphoepithelial lesions are rare in adults, reported as associated with thyroiditis or adjacent to tumours. Here we report a unique case of a thyroid solid nodule with benign lymphoepithelial morphology. A 56-year-old woman presented with a thyroid nodule increasing in size. Thyroid function was normal. On the surgical resection specimen, in addition to a 2-cm follicular adenoma, there was, at distance, a 0.5-cm solid nodule with lymphoepithelial morpholo...περισσ?τερα ?
Supraclavicular nerve entrapment
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 3 δευτερ?λεπταFolia Morphologica Supraclavicularis proprius muscle associated with supraclavicular nerve entrapment A. Raikos, T. English, A. Agnihotri, O. K. Yousif, M. Sandhu, J. Bennetto, A. Stirling ·Thursday, February 12, 2015, 1:13 Entrapment neuropathy of the supraclavicular nerve is rare and, when it occurs, is usually attributable to branching of the nerve into narrow bony clavicular canals. We describe another mechanism for entrapment of this nerve with the aberrant muscle; supraclavicularis being found during the routine dissection of an embalmed 82-year-old cadaver. Our report details a...περισσ?τερα ?
OSA : Repetitive transcranial magnetic stimulation of upper airway muscles
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 3 δευτερ?λεπταExperimental Physiology Mechanical effects of repetitive transcranial magnetic stimulation of upper airway muscles in awake obstructive sleep apnea subjects Eric Rousseau, Simon Gakwaya, César Augusto Melo-silva, Frédéric Sériès · Friday, February 13, 2015, 12:49 Stimulation of upper airway (UA) muscles during sleep by isolated transcranial magnetic stimulation (TMS) twitch can improve airflow dynamics without arousal but the effect of repetitive TMS (rTMS) on UA dynamics is unknown. Phrenic nerve magnetic stimulation (PNMS) can be used to produce painless experimental twitch-induced ... περισσ?τερα ?
Folia Morphologica
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 4 δευτερ?λεπταFolia Morphologica Synovial membrane asks for independence S. Moskalewski, A. Osiecka-iwan, E. Jankowska-steifer, A. Hyc · Thursday, February 12, 2015, 1:13 Synovial membrane is traditionally considered as a part of the joint capsule. It, however, differs from fibrous part of the capsule in development, structure, function, vascularisation, innervation and involvement in pathological processes. Moreover, in some areas, it even does not contact with the fibrous capsule. Thus, it appears that the synovial membrane should be considered as an independent organ and not as the lining of th...περισσ?τερα ?
Nuclear Medicine
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 7 δευτερ?λεπταEuropean Journal of Nuclear Medicine and Molecular Imaging Preclinical evaluation of [ 18 F]2FNQ1P as the first fluorinated serotonin 5-HT 6 radioligand for PET imaging Saturday, February 14, 2015, 5:32 AbstractPurpose Brain serotonin 6 receptor (5-HT6) is one of the most recently identified serotonin receptors. It is a potent therapeutic target for psychiatric and neurological diseases, e.g. schizophrenia and Alzheimer’s disease. Since no specific fluorinated radioligand has yet been successfully used to study this receptor by positron emission tomography (PET) neuroimaging, the obje... περισσ?τερα ?
Disease Markers
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 7 δευτερ?λεπταDisease Markers Sequence Variants of Peroxisome Proliferator-Activated Receptor-Gamma Gene and the Clinical Courses of Patients with End-Stage Renal Disease Chia-ter Chao, Yen-ching Chen, Chih-kang Chiang, Jenq-wen Huang, Fu-chang Hu, Cheng-chung Fang, Chen-chih Chang, And Chung-jen Yen · Sunday, February 15, 2015, 12:36 Background. PPAR-γ single nucleotide polymorphisms (SNPs) reportedly play an important role in determining metabolic risk among diverse population. Whether PPAR-γ SNPs affect the clinical courses in ESRD patients is unknown. Methods. From a multicenter cohort, we iden... περισσ?τερα ?
HNC : Primary tumor asphericity in pretherapeutic FDG PET
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 8 δευτερ?λεπταEuropean Journal of Nuclear Medicine and Molecular Imaging Increased evidence for the prognostic value of primary tumor asphericity in pretherapeutic FDG PET for risk stratification in patients with head and neck cancer Saturday, FHNC :ebruary 14, 2015, 5:32 AbstractPurpose In a previous study, we demonstrated the first evidence that the asphericity (ASP) of pretherapeutic FDG uptake in the primary tumor provides independent prognostic information in patients with head and neck cancer. The aim of this work was to confirm these results in an independent patient group examined at a diff... περισσ?τερα ?
Oropharyngeal cancer : Zone-size nonuniformity of 18 F-FDG PET regional textural features
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 8 δευτερ?λεπταEuropean Journal of Nuclear Medicine and Molecular Imaging Zone-size nonuniformity of 18 F-FDG PET regional textural features predicts survival in patients with oropharyngeal cancer Saturday, February 14, 2015, 5:32 AbstractPurpose The question as to whether the regional textural features extracted from PET images predict prognosis in oropharyngeal squamous cell carcinoma (OPSCC) remains open. In this study, we investigated the prognostic impact of regional heterogeneity in patients with T3/T4 OPSCC. Methods We retrospectively reviewed the records of 88 patients with T3 or T4 OPSCC who... περισσ?τερα ?
Cancer stem cell enrichment marker CD98
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 8 δευτερ?λεπταEuropean Journal of Cancer Cancer stem cell enrichment marker CD98: A prognostic factor for survival in patients with human papillomavirus-positive oropharyngeal cancer Sunday, February 15, 2015, 17:24 Publication date: March 2014 *Source:*European Journal of Cancer, Volume 50, Issue 4 Author(s): Michelle M. Rietbergen , Sanne R. Martens-de Kemp , Elisabeth Bloemena , Birgit I. Witte , Arjen Brink , Robert J. Baatenburg de Jong , C. René Leemans , Boudewijn J.M. Braakhuis , Ruud H. Brakenhoff Purpose Several hypotheses have been proposed to explain the relatively good prognosis of patie... περισσ?τερα ?
Relationship Satisfaction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 8 δευτερ?λεπταEar infections Relationship Satisfaction Reduces the Risk of Maternal Infectious Diseases in Pregnancy: The Norwegian Mother and Child Cohort Study Roger Ekeberg Henriksen Et Al. · Saturday, February 14, 2015, 2:51 by Roger Ekeberg Henriksen, Torbj?rn Torsheim, Frode Thuen Objectives The aims of this study were to explore the degree to which relationship satisfaction predicts the risk of infectious diseases during pregnancy and to examine whether relationship satisfaction moderates the association between stressful life events and the risk of infections. Methods This was a prospective s... περισσ?τερα ?
The TNM-classification for gastric cancer
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 11 δευτερ?λεπταEuropean Journal of Cancer Validating the prognostic and discriminating value of the TNM-classification for gastric cancer – A critical appraisal Thursday, February 12, 2015, 20:58 Publication date: Available online 11 February 2015 *Source:*European Journal of Cancer Author(s): C. R?cken , H.-M. Behrens Aim We investigated the effect of the new tumour-, node-, metastasis- (TNM) classification on predicting and discriminating gastric cancer patient prognosis using the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) Program. Patients and methods From the SEE... περισσ?τερα ?
Functional health status in oropharyngeal dysphagia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 14 δευτερ?λεπταBiomed Res Int. doi: 10.1155/2014/458678 Psychometric properties of questionnaires on functional health status in oropharyngeal dysphagia: a systematic literature review. Speyer R1, Cordier R2, Kertscher B3, Heijnen BJ4. Author information 1School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, QLD 4811, Australia ; Department of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. 2School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook Universit... περισσ?τερα ?
Swallowing between high and low concentration taste stimuli
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 14 δευτερ?λεπτα*Differences in swallowing between high and low concentration taste stimuli.* Biomed Res Int. Authors: Nagy A, Steele CM, Pelletier CA Abstract Taste is a property that is thought to potentially modulate swallowing behavior. Whether such effects depend on taste, intensity remains unclear. This study explored differences in the amplitudes of tongue-palate pressures in swallowing as a function of taste stimulus concentration. Tongue-palate pressures were collected in 80 healthy women, in two age groups (under 40, over 60), stratified by genetic taste status (nontasters, supertasters... περισσ?τερα ?
Motor, Oculomotor and Cognitive Function in Progressive Supranuclear Palsy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 17 δευτερ?λεπταDysphagia A Longitudinal Study of Boyd C. P. Ghosh Et Al. · Thursday, February 12, 2015, 8:17 by Boyd C. P. Ghosh, Roger H. S. Carpenter, James B. Rowe Objective We studied the annual change in measures of motor, oculomotor and cognitive function in progressive supranuclear palsy. This had twin objectives, to assess the potential for clinical parameters to monitor disease progression in clinical trials and to illuminate the progression of pathophysiology. Methods Twenty three patients with progressive supranuclear palsy (Richardson’s syndrome) were compared to 22 matched controls at ba...περισσ?τερα ?
Polyphenols in Targeting Oxidative Stress
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 17 δευτερ?λεπτα*Selected Attributes of Polyphenols in Targeting Oxidative Stress in Cancer.* Curr Top Med Chem. 2015 Feb ; Authors: Stepani? V, Gasparovi? A?, Tro?elj KG, Ami?a D, ?arkovi? N Abstract Various plant polyphenols have been recognized as redox active molecules. This review discusses some aspects of polyphenols' modes of redox action, corresponding structure - activity relationships and their potential to be applied as adjuvants to conventional cytostatic drugs. Polyphenols' antioxidative capacity has been discussed as the basis for targeting oxidative stress and, consequently, for their ...περισσ?τερα ?
Ipsilateral and bilateral auditory stimuli on audiovisual integration
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 17 δευτερ?λεπτα*Effects of ipsilateral and bilateral auditory stimuli on audiovisual integration: a behavioral and event-related potential study.* Neuroreport. Authors: Gao Y, Li Q, Yang W, Yang J, Tang X, Wu J Abstract We used event-related potential measures to compare the effects of ipsilateral and bilateral auditory stimuli on audiovisual (AV) integration. Behavioral results showed that the responses to visual stimuli with either type of auditory stimulus were faster than responses to visual stimuli only and that perceptual sensitivity (d') for visual detection was enhanced for visual stimuli ... περισσ?τερα ?
The midbrain superior and inferior colliculi
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 17 δευτερ?λεπτα*Disinhibition of the midbrain colliculi unmasks coordinated autonomic, respiratory, and somatomotor responses to auditory and visual stimuli.* Am J Physiol Regul Integr Comp Physiol. Authors: Müller-Ribeiro FC, Dampney RA, McMullan S, Fontes MA, Goodchild AK Abstract The midbrain superior and inferior colliculi have critical roles in generating coordinated orienting or defensive behavioral responses to environmental stimuli, and it has been proposed that neurons within the colliculi can also generate appropriate cardiovascular and respiratory responses to support such behavioral res... περισσ?τερα ?
Dentomaxillofacial Radiology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 18 δευτερ?λεπτα*Influence of CBCT enhancement filters on diagnosis of vertical root fractures: a simulation study in endodontically treated teeth with and without intracanal posts.* Dentomaxillofac Radiol. 2015 Feb ;:20140352 Authors: Ferreira LM, Visconti MA, Nascimento HA, Dallemolle RR, Ambrosano GM, Freitas DQ Abstract Objectives: To evaluate the influence of CBCT enhancement filters on the diagnosis of vertical root fractures (VRFs) in teeth with and without metal posts. Methods: The crowns of 40 uniradicular human teeth were removed and all roots were prepared. 20 teeth were randomly selected,...περισσ?τερα ?
Allergy and Clinical Immunology
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 20 δευτερ?λεπταCurrent Opinion in Allergy and Clinical Immunology - Published Ahead-of-Print Childhood asthma and chronic obstructive pulmonary disease: outcomes until the age of 50. Tai, Andrew · Friday, February 13, 2015, 4:30 Purpose of review: There has been recent interest in understanding the origins of chronic obstructive pulmonary disease. Epidemiological studies suggest that chronic obstructive pulmonary disease clearly has other causes apart from tobacco smoke. Recent findings: Cross-sectional studies of adult cohorts with chronic obstructive pulmonary disease highlight that childhood ast...περισσ?τερα ?
Cranio-Maxillo-Facial Surgery
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 20 δευτερ?λεπταCranio-Maxillo-Facial Surgery Long-term results of ORIF of condylar head fractures of the mandible: A prospective 5-year follow-up study of small-fragment positional-screw osteosynthesis (SFPSO) Andreas Kolk, Andreas Neff · Friday, February 13, 2015, 4:49 Optimum treatment of condylar head fractures (CHF) remains subject to controversy. There are currently a variety of alternative techniques applied, data in literature are often inconsistent and especially systematic long-term data on results after treatment by open reduction and internal fixation (ORIF) have so far not been available... περισσ?τερα ?
Auditory gating deficit
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 26 δευτερ?λεπτα*Application of neurophysiological biomarkers for Huntington's disease: evaluating a phosphodiesterase 9A inhibitor.* Exp Neurol. 2015 Authors: Nagy D, Tingley FD, Stoiljkovic M, Hajós M Abstract Several neurophysiological abnormalities have been described in Huntington's disease, including auditory gating deficit, which are considered to reflect impaired brain information-processing. Since transgenic animal models of Huntington's disease capture basic neuropathology of the disorder, auditory gating was studied in BACHD (line5) transgenic rats and Q175 transgenic mice, together with... περισσ?τερα ?
The central auditory nervous system (CANS) dysfunction in children with cleft palates
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 26 δευτερ?λεπτα*[Electrophysiological study on the central auditory nervous system dysfunction in children with cleft palates].* Hua Xi Kou Qiang Yi Xue Za Zhi. Authors: Feng Y, Huang S, Yuhan X Abstract OBJECTIVE: We aim to explore the central auditory nervous system (CANS) functioning in children with nonsyndromic cleft palates by analyzing the auditory evoked potentials and event-related potentials (ERP). METHODS: A total of 34 children with nonsyndromic cleft palates were recruited as subjects, and 27 normally developed children were selected as the normal controls. Auditory brainstem response (...περισσ?τερα ?
Mismatch negativity (MMN) is a component of the event-related potential elicited by deviant auditory stimuli
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 28 δευτερ?λεπτα*Mismatch negativity in recent-onset and chronic schizophrenia: a current source density analysis.* PLoS One. Authors: Fulham WR, Michie PT, Ward PB, Rasser PE, Todd J, Johnston PJ, Thompson PM, Schall U Abstract . It is presumed to index pre-attentive monitoring of changes in the auditory environment. MMN amplitude is smaller in groups of individuals with schizophrenia compared to healthy controls. We compared duration-deviant MMN in 16 recent-onset and 19 chronic schizophrenia patients versus age- and sex-matched controls. Reduced frontal MMN was found in both patient groups, in... περισσ?τερα ?
Gain modulation of synaptic inputs by network state in auditory cortex
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 29 δευτερ?λεπτα* in vivo.* J Neurosci. 2015 Feb ;35(6):2689-702 Authors: Reig R, Zerlaut Y, Vergara R, Destexhe A, Sanchez-Vives MV Abstract The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia. These different states of cortical activation gain modulate synaptic transmission. However, the reported modulation that Up states impose on synaptic inputs is disparate in the literature, including both increases and decreases of responsiveness. Here, we tested the hypothesis that such disparate ob...περισσ?τερα ?
Computer Speech & Language
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 29 δευτερ?λεπταComputer Speech & Language Fast vocabulary acquisition in an NMF-based self-learning vocal user interface *Source:*Computer Speech & Language, Volume 28, Issue 4 Author(s): Bart Ons , Jort F. Gemmeke , Hugo Van hamme In command-and-control applications, a vocal user interface (VUI) is useful for handsfree control of various devices, especially for people with a physical disability. The spoken utterances are usually restricted to a predefined list of phrases or to a restricted grammar, and the acoustic models work well for normal speech. While some state-of-the-art methods allow fo... περισσ?τερα ?
Dermal Leishmaniasis
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 30 δευτερ?λεπταCMR Current Issue Species Typing in Dermal Leishmaniasis [Reviews] Van Der Auwera, G., Dujardin, J.-c. · Thursday, February 12, 2015, 11:32 SUMMARY *Leishmania* is an infectious protozoan parasite related to African and American trypanosomes. All *Leishmania* species that are pathogenic to humans can cause dermal disease. When one is confronted with cutaneous leishmaniasis, identification of the causative species is relevant in both clinical and epidemiological studies, case management, and control. This review gives an overview of the currently existing and most used assays for speci...περισσ?τερα ?
Radioiodine Ablative Doses
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 31 δευτερ?λεπταClinical Thyroidology Radioiodine Ablative Doses Greater Than 54 mCi Improve Recurrence-Free Survival in Older Patients With Differentiated Thyroid Cancer Jerome M. Hershman · Monday, February 16, 2015, 4:49 Clinical Thyroidology Feb 2015, Vol. 27, No. 2: 43-44.
BRAF V600E Mutations - Survival in PTC
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 31 δευτερ?λεπταClinical Thyroidology BRAF V600E Mutations Are Common but May Not Predict Survival in PTC Cord Sturgeon · Monday, February 16, 2015, 4:49 Clinical Thyroidology Feb 2015, Vol. 27, No. 2: 40-42.
Atherosclerosis in Hypothyroidism
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 31 δευτερ?λεπταCould Low Omentin-1 Increase the Risk of Atherosclerosis in Hypothyroidism? Clinical Thyroidology February 2015, Vol. 27, No. 2, 34-36
The Dose of Ionizing Radiation During Childhood
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 35 δευτερ?λεπταClinical Thyroidology The Dose of Ionizing Radiation During Childhood Is Associated with the Prevalence of Thyroid Nodules Even Nearly 60 Years Later Angela M. Leung · Monday, February 16, 2015, 4:49 Clinical Thyroidology Feb 2015, Vol. 27, No. 2: 37-39.
Statins and Thyroidectomy May Reduce the ?Risk of Orbitopathy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 38 δευτερ?λεπταClinical Thyroidology Statins and Thyroidectomy May Reduce the Risk of Orbitopathy Developing in Patients with Graves’ Disease Jerome M. Hershman · Monday, February 16, 2015, 4:49 Clinical Thyroidology Feb 2015, Vol. 27, No. 2: 32-33.
Selenium Supplementation in Pregnancy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 40 δευτερ?λεπταClinical Thyroidology Selenium Supplementation in Pregnancy Did Not Improve Thyroid Function or Thyroid Autoimmunity Elizabeth N. Pearce · Monday, February 16, 2015, 4:49 Clinical Thyroidology Feb 2015, Vol. 27, No. 2: 30-31.
Macro-TSH
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 40 δευτερ?λεπταClinical Thyroidology The Concept of Macro-TSH Revisited Jacques Orgiazzi · Monday, February 16, 2015, 4:49 Clinical Thyroidology Feb 2015, Vol. 27, No. 2: 26-29.
Clinical Otolaryngology
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 42 δευτερ?λεπταClinical Otolaryngology Post-operative changes in telemetry measurements after cochlear implantation and its impact on early activation Astrid Wolf-magele, Johannes Schnabl, Stefan Edlinger, Stefan Marcel Pok, Philipp Schoerg, Georg Mathias Sprinzl · Monday, February 16, 2015, 13:59 Abstract Introduction Cochlear implantation is a clinical routinely treatment for patients with severe sensorineural hearing loss for over 20 years. Up to now, the general recommendation for speech processor activation was four weeks after cochlear implantation. The aim of this study was to determine whethe...περισσ?τερα ?
Presence of comorbidity (atopy, bronchial asthma, aspirin intolerance)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 43 δευτερ?λεπταClinical Otolaryngology Comorbidity has no impact on eosinophil inflammation in the upper airways or on severity of the sinonasal disease in patients with nasal polyps Barbora Uhliarova, Jana Kopincova, Maros Kolomaznik, Marian Adamkov, Martin Svec, Andrea Calkovska · Monday, February 16, 2015, 13:59 Abstract Objective The study was designed to determine whether there is an association between the comorbidity as atopy, bronchial asthma, aspirin intolerance and eosinophil infiltration of the upper airways, severity of the sinonasal disease and rate of revision sinus surgery in patients ...περισσ?τερα ?
The intravenous pan-class I isoform PI3K/mTOR inhibitor PF-05212384 in patients with advanced solid tumors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 43 δευτερ?λεπταClinical Cancer Research Online First Articles First-In-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR In Patients With Advanced Cancer Shapiro, G. I., Bell-mcguinn, K. M., Molina, J. R., Bendell, J. C., Spicer, J., Kwak, E. L., Pandya, S. S., Millham, R., Borzillo, G., Pierce, K. J., Han, L., Houk, B. E., Gallo, J. D., Alsina, M., Brana, I., Tabernero, J. · Saturday, February 14, 2015, 9:41 Purpose: To evaluate safety (primary endpoint), tolerability, pharmacokinetics, pharmacodynamic profile, and preliminary activity of the intr... περισσ?τερα ?
Chemotherapy rescues hypoxic tumor cells and induces their reoxygenation and repopulation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 43 δευτερ?λεπταClinical Cancer Research Online First Articles - an effect that is inhibited by the hypoxia-activated pro-drug TH-302 Saggar, J. K., Tannock, I. F. · Friday, February 13, 2015, 5:14 Purpose: Chemotherapy targets rapidly-proliferating tumor cells, but spares slowly-proliferating hypoxic cells. We hypothesized that nutrition of hypoxic cells would improve in intervals between chemotherapy, and that hypoxic cells destined to die without treatment would survive and proliferate. Experimental Design: We therefore evaluated repopulation and reoxygenation following chemotherapy, and the effec... περισσ?τερα ?
Clinical Oral Investigations
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 44 δευτερ?λεπταClinical Oral Investigations The association between temporomandibular disorders and joint hypermobility syndrome: a nationwide population-based study Monday, February 16, 2015, 12:40 AbstractObjectives This study aims to investigate the risk factors of temporomandibular disorders (TMDs), including disc or non-disc-related disorders, and joint hypermobility syndrome (JHS) retrospectively and to analyze the factors by estimating the magnitude of the association between the two conditions using a nationwide population-based dataset. Materials and methods A total of 975,788 eligible patie...περισσ?τερα ?
Case Reports in Otolaryngology
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 44 δευτερ?λεπταCase Reports in Otolaryngology Conservative Management for Lingual Thyroid Ectopic Eder Alberto Sigua-rodriguez, Douglas Rangel Goulart, Luciana Asprino, And Afonso Celso De Moraes Manzano · Sunday, February 15, 2015, 14:15 Lingual thyroid gland is a rare clinical entity. The presence of an ectopic thyroid gland located at the base of the tongue may be presented with symptoms like dysphagia, dysphonia, and upper airway obstruction. We are introducing a case of an 8-year-old girl who had lingual thyroid that presented dysphagia and foreign body sensation in the throat. The diagnostic w...περισσ?τερα ?
Clinical Neurophysiology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 46 δευτερ?λεπταClinical Neurophysiology Editorial Board Monday, February 16, 2015, 10:26 Publication date: March 2015 *Source:*Clinical Neurophysiology, Volume 126, Issue 3 Tags: - - - - - - Clinical Neurophysiology Contents Monday, February 16, 2015, 10:26 Publication date: March 2015 *Source:*Clinical Neurophysiology, Volume 126, Issue 3 Tags: - - - - - - Clinical Neurophysiology Early epileptiform discharges and the yield of prolonged EEG monitoring Monday, February 16, 2015, 10:26 Publication date: March 2015 *Source:*Clinical Neurophysiology, Volume 126, Is... περισσ?τερα ?
Clinical Cancer Research
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 51 δευτερ?λεπταClinical Cancer Research Online First Articles Stromal CD8+ T Cell Density - A Promising Supplement to TNM staging in Non-Small Cell Lung Cancer Donnem, T., Hald, S. M., Paulsen, E.-e., Richardsen, E., Al-saad, S., Kilvaer, T. K., Brustugun, O. T., Helland, A., Lund-iversen, M., Poehl, M., Olsen, K. E., Ditzel, H. J., Hansen, O., Al-shibli, K. I., Kiselev, Y., Sandanger, T. M., Andersen, S., Pezzella, F., Bremnes, R. M., Busund, L.-t. R. · Saturday, February 14, 2015, 9:41 Purpose: Immunoscore is a prognostic tool defined to quantify in situ immune cell infiltrates, which appears to b...περισσ?τερα ?
KAI1-induced apoptosis and proliferation inhibition
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 51 δευτερ?λεπταClinical and translational oncology Hypoxia and Serum deprivation protected MiaPaCa-2 cells from KAI1-induced proliferation inhibition through autophagy pathway activation in solid tumors Wednesday, February 11, 2015, 17:52 AbstractPurpose KAI1 closely correlates with pancreatic cancer metastasis. There might be some factors that protect the cells from a proliferation inhibition by KAI1 in the solid tumors’ microenvironment. Hypoxia and ischemia are the main characteristics of the microenvironment within solid tumors. Whether they affect the KAI1 inhibitory effects on cell proliferati... περισσ?τερα ?
Osteoblastic and osteolytic bone metastases
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 51 δευτερ?λεπταClinical and translational oncology Differences of osteoblastic bone metastases and osteolytic bone metastases in clinical features and molecular characteristics Wednesday, February 11, 2015, 17:52 Abstract Several cancers tend to metastasize to bone, leading to osteolytic or osteoblastic bone lesions. The respective phenotypes of bone destruction and bone formation vary in clinical features, including incidence, prognosis, skeletal-related events and bone biomarkers. In addition, different molecular mechanisms explain the difference in phenotype. For example, molecules involved i*n o... περισσ?τερα ?
Cleft Palate Formation and Delayed Tooth Differentiation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 51 δευτερ?λεπταCleft palate Augmented BMPRIA-Mediated BMP Signaling in Cranial Neural Crest Lineage Leads to Cleft Palate Formation and Delayed Tooth Differentiation Lu Li Et Al. · Saturday, February 14, 2015, 1:30 by Lu Li, Ying Wang, Minkui Lin, Guohua Yuan, Guobin Yang, Yuqian Zheng, YiPing Chen The importance of BMP receptor Ia (BMPRIa) mediated signaling in the development of craniofacial organs, including the tooth and palate, has been well illuminated in several mouse models of loss of function, and by its mutations associated with juvenile polyposis syndrome and facial defects in humans. In ...περισσ?τερα ?
Cerebrospinal fluid gusher in cochlear implantation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 51 δευτερ?λεπταCochlear Implants Int. Authors: Eftekharian A, Amizadeh M Abstract OBJECTIVES: To share our experience of cerebrospinal fluid (CSF) gusher in cochlear implantation. METHODS: Demographic, radiological, and surgical results of patients with CSF gusher in 523 consecutive cochlear implant recipients including children and adults as well as our management technique were evaluated and a review of the literature has been included. RESULTS: Fifteen (2.87%) cases had CSF gusher. Two patients (13.3%) were adults with post-lingual hearing loss and the rest 12 (86.7%) were children with congenita... περισσ?τερα ?
OSA : Reduced innervation in the pharynx
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 51 δευτερ?λεπτα*Reduced innervation in the human pharynx in patients with obstructive sleep apnea.* Histol Histopathol. 2015 Feb ;:11593 Authors: de Carlos F, Cobo J, Macías E, Feito J, González M, Cobo T, Fernández-Mondragón MP, García-Suárez O, Vega JA Abstract Obstructive sleep apnea is a disease characterized by repetitive breathing during sleep that lead to reduced oxygen saturation and sleep disturbance among other symptoms. Obstructive sleep apnea is caused by blockade of the upper respiratory airway, although the pathogenic mechanism underlying this occlusion remains unknown. In these studie...περισσ?τερα ?
Retinitis pigmentosa
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 51 δευτερ?λεπτα*Progress in histopathologic and pathogenesis research in a retinitis pigmentosa model.* Histol Histopathol. 2015 Feb ;:11596 Authors: Liu X, Zhang Y, He Y, Zhao J, Su G Abstract Retinitis pigmentosa is a major cause of visual impairment and blindness, affecting millions of people worldwide. The mechanisms of and effective treatments for the disease, however, remain to be further investigated. The Royal College of Surgeons rat is one of the most widely used animal models for the study of retinal degeneration diseases. The mutation in the mer tyrosine kinase proto-oncogene of this mode... περισσ?τερα ?
Clinical and translational oncology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 54 δευτερ?λεπταClinical and translational oncology MicroRNA-10b indicates a poor prognosis of non-small cell lung cancer and targets E-cadherin Wednesday, February 11, 2015, 17:52 AbstractBackground MicroRNA-10b(miR-10b) has been reported to be dysregulated in some types of cancer and to play an important role in invasion and metastasis. It was previously found to be a tumor enhancer in NSCLC; however, its clinical significance in NSCLC has not been evaluated. Methods We compared the expression levels of miR-10b in 73 pairs of NSCLC tissues and the corresponding noncancerous tissues, as well as in hu... περισσ?τερα ?
Thymus development
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 54 δευτερ?λεπτα*Effect of boric acid supplementation of ostrich water on the expression of Foxn11 in thymus.* Histol Histopathol. 2015 Feb ;:11595 Authors: Xiao K, Ansari AR, Rehman ZU, Khaliq H, Song H, Tang J, Wang J, Wang W, Sun PP, Zhong J, Peng KM Abstract Foxn1 is essential for thymus development. The relationship between boric acid and thymus development, optimal dose of boric acid in ostrich diets, and the effects of boric acid on the expression of Foxn1 were investigated in the present study. Thirty healthy ostriches were randomly divided into six groups: Group I, II, III, IV, V, VI, and su... περισσ?τερα ?
Case Reports in Medicine
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 1 ?ραCase Reports in Medicine Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography, Fluorescein Angiography, and Autofluorescence Findings Tu?ba Aydo?an, Esra Güney, Betül I?lkay Sezgin Ak?ay, Tahir Kansu Bozkurt, Cihan ünlü, And Ahmet Ergin · Thursday, February 12, 2015, 12:20 A 17-year-old presented with central and paracentral scotomas in his right eye for one week. There was no remarkable medical or ocular history. Blood analyses were within normal range. At presentation both eyes’ best-corrected visual acuities were 20/20. Slit-lamp examination result was n...περισσ?τερα ?
Proton Radiobiology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραCancers Cancers, Vol. 7, Pages 353-381: Francesco Tommasino · Thursday, February 12, 2015, 17:01 In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly increased biological effectiveness is taken into account in proton treatment planning by assumi...περισσ?τερα ?
Allogeneic innate lymphocyte therapy with prior cranial irradiation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραCancer Immunology, Immunotherapy The safety of allogeneic innate lymphocyte therapy for glioma patients with prior cranial irradiation Saturday, February 14, 2015, 0:23 Abstract The standard treatment of high-grade glioma presents a combination of radiotherapy, chemotherapy and surgery. Immunotherapy is proposed as a potential adjunct to standard cytotoxic regimens to target remaining microscopic disease following resection. We have shown ex vivo expanded/activated γδ T cells to be a promising innate lymphocyte therapy based on their recognition of stress antigens expressed on gliomas... περισσ?τερα ?
Anti-tumor activity in CD8 + T cells
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραCancer Immunology, Immunotherapy Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8 + T cells Saturday, February 14, 2015, 0:23 Abstract Mouse CD8+ T cells conditioned with interleukin (IL)-12 ex vivo mediate the potent regression of established melanoma when transferred into lymphodepleted mice. However, the quantitative and qualitative changes induced by IL-12 in the responding mouse CD8+ T cells have not been well defined. Moreover, the mechanisms by which IL-12-conditioning impacts human CD8+ T cells, and how such cells might be expanded prior to ... περισσ?τερα ?
Brazilian Oral Research
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 1 ?ραBrazilian Oral Research Esthetic perception of facial profile after treatment with the Thurow appliance Monday, February 16, 2015, 12:33 The objective of this article was to investigate the perception of esthetic changes in the facial profile of bilateral Class II patients treated with the Modified Thurow Appliance for extraoral treatment. Silhouettes were traced of profiles of patients who initially presented a bilateral Class II molar relationship and who, post-treatment, presented molars in a Class I relationship. Three groups were formed: the first composed of patients with maxil... περισσ?τερα ?
Head and Neck Radiotherapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραBioMed Research International Evaluation of Deformable Image Registration Methods for Dose Monitoring in Head and Neck Radiotherapy Bastien Rigaud, Antoine Simon, Jo?l Castelli, Maxime Gobeli, Juan-david Ospina Arango, Guillaume Cazoulat, Olivier Henry, Pascal Haigron, And Renaud De Crevoisier ·Wednesday, February 11, 2015, 20:04 In the context of head and neck cancer (HNC) adaptive radiation therapy (ART), the two purposes of the study were to compare the performance of multiple deformable image registration (DIR) methods and to quantify their impact for dose accumulation, in healthy... περισσ?τερα ?
Tetramethylpyrazine Enhances Vascularization and Prevents Osteonecrosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραBioMed Research International in Steroid-Treated Rats Yini Jiang, Chunfang Liu, Weiheng Chen, Hui Wang, Chao Wang, And Na Lin ·Wednesday, February 11, 2015, 20:04 Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is an avascular necrosis disease of bone. Tetramethylpyrazine (TMP), with significant vascular protective properties, has been widely used for the treatments of ischemic neural disorders and cardiovascular diseases. However, its role in the treatment of steroid-induced ONFH has not been evaluated. In this study, our results showed that TMP significantl...περισσ?τερα ?
BioMed Research International
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 1 ?ραBioMed Research International Hypergravity Stimulation Enhances PC12 Neuron-Like Cell Differentiation Giada Graziana Genchi, Francesca Cialdai, Monica Monici, Barbara Mazzolai, Virgilio Mattoli, And Gianni Ciofani · Monday, February 16, 2015, 13:21 Altered gravity is a strong physical cue able to elicit different cellular responses, representing a largely uninvestigated opportunity for tissue engineering/regenerative medicine applications. Our recent studies have shown that both proliferation and differentiation of C2C12 skeletal muscle cells can be enhanced by hypergravity treatment; ...περισσ?τερα ?
Epinephrine Administration in Lipid-Based Resuscitation
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 1 ?ρα* in a Rat Model of Bupivacaine-Induced Cardiac Arrest: Optimal Timing.* Reg Anesth Pain Med. 2015 Feb ; Authors: Jin Z, Xia Y, Xia F, Wu C, Chen Z, Nan F, Wu B, Wan L, Wang X, Papadimos TJ, Xu X Abstract BACKGROUND AND OBJECTIVES: The medical community commonly uses lipid emulsion combined with epinephrine in local anesthetic-induced cardiac arrest, but the optimal timing of epinephrine administration relative to lipid emulsion is currently unknown and needs to be determined. METHODS: Thirty adult male Sprague-Dawley rats were subjected to bupivacaine-induced asystole and were then ra... περισσ?τερα ?
Neuroradiology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 1 ?ραAmerican Journal of Neuroradiology current issue Imaging Evidence and Recommendations for Traumatic Brain Injury: Advanced Neuro- and Neurovascular Imaging Techniques [FELLOWS' JOURNAL CLUB] Wintermark, M., Sanelli, P. C., Anzai, Y., Tsiouris, A. J., Whitlow, C. T., On Behalf Of The American College Of Radiology Head Injury Institute · Wednesday, February 11, 2015, 20:00 SUMMARY: Neuroimaging plays a critical role in the evaluation of patients with traumatic brain injury, with NCCT as the first-line of imaging for patients with traumatic brain injury and MR imaging being recommended in... περισσ?τερα ?
There are 2 groups of patients with congenital smell loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAmerican Journal of Otolaryngology Erythrocyte membrane antigen frequencies in patients with Type II congenital smell loss Friday, February 13, 2015, 8:49 Publication date: March–April 2015 *Source:*American Journal of Otolaryngology, Volume 36, Issue 2 Author(s): William A. Stateman , Robert I. Henkin , Alexandra B. Kn?ppel , Willy A. Flegel Objective The objective of this study was to determine whether there are genetic factors associated with Type II congenital smell loss. Study design The expression frequencies of 16 erythrocyte antigens among patients with Type II congenital smell...περισσ?τερα ?
Retromolar trigone SCC
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAmerican Journal of Otolaryngology Retromolar trigone squamous cell carcinoma treated with radiotherapy alone or combined with surgery: a 10-year update Friday, February 13, 2015, 8:49 Publication date: March–April 2015 *Source:*American Journal of Otolaryngology, Volume 36, Issue 2 Author(s): Kathryn E. Hitchcock , Robert J. Amdur , Christopher G. Morris , John W. Werning , Peter T. Dziegielewski , William M. Mendenhall Purpose/objectives Treatment outcomes were analyzed for patients who received radiotherapy for squamous cell carcinoma of the retromolar trigone at a single institution... περισσ?τερα ?
Ansa to recurrent laryngeal neurorrhaphy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAmerican Journal of Otolaryngology Ansa to recurrent laryngeal neurorrhaphy in the setting of laryngeal nerve sacrifice: a cadaveric study to evaluate a reconstructive option Friday, February 13, 2015, 8:49 Publication date: March–April 2015 *Source:*American Journal of Otolaryngology, Volume 36, Issue 2 Author(s): Joseph Scharpf , Timothy Haffey , Karthik Rajasekaran , Robert Lorenz , Jennifer McBride Objective In certain cases, the recurrent laryngeal nerve (RLN) has to be sacrificed. This often results in an inadequate length of residual RLN to be used in a reinnervation procedure. W...περισσ?τερα ?
The one-cut meatoplasty
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAmerican Journal of Otolaryngology The one-cut meatoplasty: novel surgical technique and outcomes Friday, February 13, 2015, 8:49 Publication date: March–April 2015 *Source:*American Journal of Otolaryngology, Volume 36, Issue 2 Author(s): Kristen L. Hovis , Matthew L. Carlson , Alex D. Sweeney , David S. Haynes Purpose To present the surgical technique and clinical outcomes of a novel modification to conventional meatoplasty. Materials and methods All consecutive patients undergoing canal wall down tympanomastoidectomy incorporating the one-cut meatoplasty technique between January 200... περισσ?τερα ?
Polyvinylidene fluoride nasal sensor to assess nasal obstruction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAmerican Journal of Otolaryngology Validation of polyvinylidene fluoride nasal sensor to assess nasal obstruction in comparison with subjective technique Friday, February 13, 2015, 8:49 Publication date: March–April 2015 *Source:*American Journal of Otolaryngology, Volume 36, Issue 2 Author(s): G. Roopa Manjunatha , D. Roy Mahapatra , Surya Prakash , K. Rajanna Objective The aim of this study is to validate the applicability of the PolyVinyliDene Fluoride (PVDF) nasal sensor to assess the nasal airflow, in healthy subjects and patients with nasal obstruction and to correlate the result... περισσ?τερα ?
Chemoradiation in elderly
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAmerican Journal of Otolaryngology Chemoradiation in elderly patients with head and neck cancers: a single institution experience Friday, February 13, 2015, 8:49 Publication date: March–April 2015 *Source:*American Journal of Otolaryngology, Volume 36, Issue 2 Author(s): Tejinder Kataria , Deepak Gupta , Shyam Singh Bisht , Shikha Goyal , Trinanjan Basu , Anurita Srivastava , Ashu Abhishek , Govardhan HB , Kuldeep Sharma , Vikash Kumar Aims To evaluate the efficacy and toxicity of concurrent chemoradiation in patients with head and neck cancers aged 65 and older. Materials and methods ... περισσ?τερα ?
American Goiter Association
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν απ? 1 ?ρα*Low and intermediate Risk Differentiated Thyroid Cancer and Radioiodine Remnant Ablation: A systematic review of the literature.* J Clin Endocrinol Metab. 2015 Feb 13;:jc20143882 Authors: Lamartina L, Durante C, Filetti S, Cooper DS Abstract Background: Radioiodine remnant ablation (RRA) has traditionally been one of the cornerstones of differentiated thyroid cancer (DTC) treatment. The decision to use RRA in low (LR) and intermediate risk (IR) patients is controversial. The aim of this review is to examine the evidence of RRA benefit in the staging, follow up, and recurrence preventi... περισσ?τερα ?
Congenital Goiter Hypothyroidism
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ρα*A Novel Missense Mutation (I26M) in DUOXA2 Causing Congenital Goiter Hypothyroidism Impairs NADPH Oxidase Activity but Not Protein Expression.* J Clin Endocrinol Metab. 2015 Feb ;:jc20143964 Authors: Liu S, Liu L, Niu X, Lu D, Xia H, Yan S Abstract Context: Dual oxidase maturation factor 2 (DUOXA2) is a component of the thyroid hydrogen peroxidase (H2O2) generator, which is crucial for hormone synthesis. Genetic defects in DUOXA2 lead to an impairment of the H2O2-generating system, in turn causing congenital hypothyroidism (CH) with goiter. Case Description: Our study aimed to identif... περισσ?τερα ?
SCD1 as a novel tumor-specific target for therapy in patients with ATC
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ρα*Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.* J Clin Endocrinol Metab. 2015 Feb ;:jc20142764 Authors: von Roemeling CA, Marlow LA, Pinkerton AB, Crist A, Miller J, Tun HW, Smallridge RC, Copland JA Abstract Context: Currently there are no efficacious therapies for patients with anaplastic thyroid carcinoma (ATC) that result in long term disease stabilization or regression. Objective: We sought to identify pathways critical for ATC cell progression and viability in an effort to develop new therapeutic strate... περισσ?τερα ?
Insights and advances in chronic urticaria
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAllergy, Asthma & Clinical Immunology - Latest Articles : a Canadian perspective Gordon Sussman · Thursday, February 12, 2015, 8:46 In the past few years there have been significant advances which have changed the face of chronic urticaria. In this review, we aim to update physicians about clinically relevant advances in the classification, diagnosis and management of chronic urticaria that have occurred in recent years. These include clarification of the terminology used to describe and classify urticaria. We also detail the development and validation of instruments to assess urticar...περισσ?τερα ?
Micro-RNAs (miRNAs),Japanese cedar pollinosis,Sublingual immunotherapy (SLIT)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ρα*Changes of micro-RNAs in asymptomatic subjects sensitized to Japanese cedar pollen after prophylactic sublingual immunotherapy.* Allergy Rhinol (Providence). 2015 Feb ; Authors: Hou B, Murata M, Said AS, Sakaida H, Masuda S, Takahashi T, Zhang Z, Takeuchi K Abstract Japanese cedar pollinosis is the predominant seasonal allergic rhinitis in Japan, and it has increased in prevalence during the past 10 years. Sublingual immunotherapy (SLIT) is considered a safe and effective treatment for pollinosis. Micro-RNAs (miRNAs) are a class of short single-stranded RNA molecules that posttranscr... περισσ?τερα ?
Methamphetamines
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν απ? 1 ?ραAllergy Rhinol (Providence). 2015 Feb ; Authors: Faucett EA, Marsh KM, Farshad K, Erman AB, Chiu AG Abstract Methamphetamines are the second most commonly used illicit drug worldwide and cost the United States health-care system $23.4 billion annually. Use of this drug affects multiple organ systems and causes a variety of clinical manifestations. Although there are commonly known sequelae of methamphetamine abuse such as "meth mouth," there is limited evidence regarding maxillary sinus manifestations. The following cases highlight the initial evaluation and management of two methamph... περισσ?τερα ?
Allergy
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 1 ?ραAllergy Excess subcutaneous tissue may preclude intramuscular delivery when using epinephrine autoinjectors in patients with anaphylaxis Jamie Johnstone, Stephanie Hobbins, Dhruv Parekh, Stephen O'hickey · Friday, February 13, 2015, 11:11 Abstract Intramuscular epinephrine is the gold standard treatment for anaphylaxis. Intramuscular injection provides more rapid and higher plasma concentrations than subcutaneous routes. Given the increasing epidemic of obesity patients are at increased risk of subcutaneous delivery, we therefore assessed the depth of subcutaneous tissue in a populati...περισσ?τερα ?
Academic Radiology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν απ? 1 ?ραAcademic Radiology The Role of Pathology Correlation Approach in Prostate Cancer Index Lesion Detection and Quantitative Analysis with Multiparametric MRI Sunday, February 15, 2015, 21:40 Publication date: Available online 13 February 2015 *Source:*Academic Radiology Author(s): Andriy Fedorov , Tobias Penzkofer , Michelle S. Hirsch , Trevor A. Flood , Mark G. Vangel , Paul Masry , Clare M. Tempany , Robert V. Mulkern , Fiona M. Fennessy Rationale and Objectives Development of imaging biomarkers often relies on their correlation with histopathology. Our aim was to compare two approaches... περισσ?τερα ?