Optimization of Photosynthesis
Scientists are dreaming up entirely new methods for photosynthesis, using the tools of synthetic biology.

Optimization of Photosynthesis

The optimization of photosynthesis through research endeavours aims to enhance the efficiency with which plants convert light energy into chemical energy, thereby improving crop yields and resilience to environmental stressors. This domain encompasses several fundamental strategies and approaches, largely focusing on overcoming the inherent limitations of photosynthetic mechanisms. Below, key fundamentals of photosynthesis optimization are delineated:

1. Overcoming Photorespiration: Photorespiration is a process that consumes energy and releases fixed carbon dioxide, particularly under high oxygen concentrations and low carbon dioxide levels. Engineering approaches aim to reroute or minimize the photorespiratory pathway to increase the efficiency of carbon fixation. For instance, introducing more efficient carbon-fixing mechanisms from C4 plants into C3 plants (such as rice and wheat) is a strategic focus.

2. Enhancing Rubisco's Efficiency: Rubisco (Ribulose-1,5-bisphosphate carboxylase/oxygenase) is the enzyme responsible for carbon fixation during photosynthesis. However, its catalytic rate is slow, and it has a dual affinity for both CO2 and O2, which leads to photorespiration. Genetic engineering aims to modify Rubisco to enhance its affinity for CO2 relative to O2 or to increase its turnover rate, thus improving the overall carbon fixation efficiency.

3. Improving Light Harvesting and Energy Transfer: Optimization efforts also focus on the light-dependent reactions of photosynthesis. This includes engineering plants to have a broader spectrum of light absorption or improving the efficiency of energy transfer within the photosystems. Altering the composition or structure of light-harvesting complexes could enable plants to utilize sunlight more effectively.

4. Increasing CO2 Concentration Mechanisms: Strategies such as the introduction of carbon concentrating mechanisms (CCMs) from algae or cyanobacteria into higher plants are being explored. CCMs enable these organisms to accumulate CO2 in the vicinity of Rubisco, significantly enhancing photosynthetic efficiency. Implementing similar systems in crops could dramatically improve their productivity under limited CO2 conditions.

5. Optimizing Photosynthetic Partitioning: Directing the products of photosynthesis towards compounds that contribute more effectively to growth and yield is another strategy. This might involve genetic modifications to increase the allocation of fixed carbon into starches, sugars, or lipids that are beneficial for energy storage, growth, or human consumption.

6. Engineering Stress Resilience: Enhancing the photosynthetic apparatus's resilience to environmental stresses such as high light intensity, drought, and salinity can prevent damage to the photosystems and maintain photosynthetic efficiency under adverse conditions. This includes the engineering of antioxidant systems, osmoprotectants, and membrane stabilizing proteins.

7. Synthetic Biology and Artificial Photosynthesis Systems: Beyond natural photosynthesis optimization, synthetic biology offers prospects for creating novel photosynthetic pathways or entirely synthetic systems that mimic or surpass natural photosynthesis efficiency. This frontier research could lead to breakthroughs in how plants capture and convert solar energy.

These fundamentals of photosynthesis optimization highlight the complexity and interdisciplinary nature of improving photosynthetic efficiency. Achieving success in this domain requires an integrated approach, combining genetics, biochemistry, molecular biology, and agricultural sciences.

The ultimate goal is to develop crops that not only withstand the challenges of a changing environment but also contribute to food security and sustainable agricultural practices.

Plants and photosynthetic micro-organisms fix carbon dioxide from the atmosphere and convert it into sugars and organic biomass, using the absorbed light energy from the sun and water from the soil, and releasing molecular oxygen as a by-product [3]


More details on optimization of photosynthesis

  1. Muhie, S.H. Optimization of photosynthesis for sustainable crop production. CABI Agric Biosci 3, 50 (2022). https://doi.org/10.1186/s43170-022-00117-3
  2. José L Araus, Ruth Sanchez-Bragado, Rubén Vicente, Improving crop yield and resilience through optimization of photosynthesis: panacea or pipe dream?, Journal of Experimental Botany, Volume 72, Issue 11, 18 May 2021, Pages 3936–3955, https://doi.org/10.1093/jxb/erab097
  3. Walter, J., and Kromdijk, J. (2022).? Here comes the sun: How optimization of photosynthetic light reactions can boost crop yields. J. Integr. Plant Biol. 64: 564–591. https://onlinelibrary.wiley.com/doi/full/10.1111/jipb.13206

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