November 2024 Issue
Journey alongside Pharmaron as we embrace the latest advancements to fast-track drug discovery for small molecules and other emerging modalities.
Integrated Drug Discovery
The discovery of a new PARP1 inhibitor
In collaboration with New Bay Pharma, we identified a potent, orally bioavailable, small molecule PARP1 inhibitor. We present translational insights through multidisciplinary data integration to support the developability assessment and the rapid identification of a high-quality candidate (NB-0290) for preclinical development.
in vitro Biology
Cancer Cell Panel Screening: Fast & Cost-Efficient
Unsure which cancer types your compounds can target? With automation-enabled screening and access to over 1,000 diverse cancer cell lines, we can fine-tune your indication by profiling your compound’s activity in up to 200 cell lines monthly.
Please contact us for a quote to see our highly competitive price structure.
Safety Assessment
An End-to-End Experience for Faster Approvals
Pharmaron’s holistic approach to safety assessment allows for seamless transitions from discovery to IND-enabling and NDA/BLA-enabling studies.
Curious if we could be helpful for your safety assessment needs?
NEWS
in vivo Pharmacology
IVIS imaging of orthotopic tumor models
Our scientists show 3 case studies on orthotopic and heterotopic mouse tumor models to illustrate tumor growth progression.
Pharmacokinetics
Tiny Tubes, Big Impact
Capillary Microsampling (CMS) is a less invasive technique that reduces stress, enabling frequent blood sampling.
We present a comparison of conventional sampling and CMS and a more sensitive LC-MS/MS method to improve PK and tox studies.
领英推荐
Bioanalysis
Quantitation of Antisense-Oligonucleotides
Pharmaron uses highly sensitive hybridization ELISA to quantify antisense oligonucleotides (ASO) in complex matrices like serum.
Drug Design
Fragment-Based Discovery of Novel MUS81 Inhibitors
Pharmaron has supported AstraZeneca’s discovery of new small molecule inhibitors against endonuclease MUS81 through innovative route design and molecule synthesis.
Chemistry
My Green Lab Certification
Pharmaron’s Hoddesdon facility is proud to have received a Gold and Platinum level ‘My Green Lab Certification’ for our Analytical Chemistry and Process Chemistry, respectively.
We are delighted to contribute to sustainable and environmentally friendly chemistry.
INSIDE PHARMARON
DMPK
Rushden, UK: Take a tour through our radiolabeled drug metabolism facility
Pharmaron can accurately characterize their ADME profile by incorporating radioactive isotopes into drug molecules. Our advanced techniques reveal precise data on drug metabolism, identifying active metabolites and potential biotransformation pathways.?
UPCOMING
Webinar
Macrocycles: An Increasingly Popular Strategy in Drug Design
This webinar will review the emergence of macrocycles as a powerful strategy in drug discovery, highlighting the principles for rational design and the benefits and challenges of this class of compounds.
In a case study, we will describe the discovery of a novel series of PKCθ inhibitors?with exquisite potency and?isoform selectivity.
Date: Thursday, December 5th, 2024
Time: 8am PT / 11am ET / 4pm UK
Would you be interested in the latest trends in drug design?