The Nobel Prize in Chemistry 2022 has been awarded.
The Royal Swedish Academy of Sciences?has awarded the Nobel Prize in Chemistry 2022 to Carolyn Bertozzi (Stanford University, CA, USA), Morten Meldal (University of Copenhagen, Denmark), and K. Barry Sharpless (Scripps Research, La Jolla, CA, USA).
For the development of click chemistry and bioorthogonal chemistry
We like to keep our eye on new and upcoming scientific developments. As The Nobel Prize in Chemistry is the pièce de resistance of scientific achievement in chemistry, we would like to congratulate the winners on attaining this prestigious award.
It just says click – and the molecules are coupled together
The Nobel Prize in Chemistry 2022 is about making difficult processes easier, a concept we are passionate about at Goodfellow.?Barry Sharpless and Morten Meldal have laid the foundation for a functional form of chemistry, click chemistry, in which molecular building blocks snap together quickly and efficiently. Carolyn Bertozzi has taken click chemistry to the next level by utilising it in living organisms.
Adam Sells , Regional Sales Manager at Goodfellow, believes it’s great to see simple answers to complex questions recognized! The complexity of chemical molecules is immense, this breakthrough enables streamlined synthesis that can have a huge effect on the world around us.
We often facilitate scientific breakthroughs by providing first-class, quality materials. But we offer much more than that. Our expert technical team are ready and waiting to assist and advise you in your current and future projects.
Chemists have long been driven by the desire to build increasingly complicated molecules. In pharmaceutical research, this has often involved artificially recreating natural molecules with medicinal properties. While these processes often lead to many admirable molecular constructions, it is generally time consuming and very expensive to produce.
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Barry Sharpless, who is now being awarded his second Nobel Prize in Chemistry, coined the concept of click chemistry around the year 2000. Click chemistry is a form of simple and reliable chemistry, where reactions occur quickly and unwanted by-products are avoided.
Shortly afterwards,?Morten Meldal?and Barry Sharpless, independently of each other, presented?the copper catalysed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use. Among many other uses, it is utilised in the development of pharmaceuticals, for mapping DNA, and creating materials that are more fit for purpose.
Carolyn Bertozzi?took click chemistry to the next level. To map important but elusive biomolecules on the surface of cells, called glycans, she developed click reactions that work inside living organisms. Her?bioorthogonal reactions?take place without disrupting the normal chemistry of the cell.
These reactions are now used globally to explore cells and track biological processes. Using bioorthogonal reactions, researchers have improved the targeting of cancer pharmaceuticals, which are now being tested in clinical trials.
Click chemistry and bioorthogonal reactions have taken chemistry into the era of functionalism. This is bringing the greatest benefit to humankind.
Dr Jason Jackson , Technical Specialist at Goodfellow thinks this wonderful and elegant piece of chemistry has opened up new routes to drug discovery and delivery that will have real world impacts. I am most excited about the research into improved targeting of cancer pharmaceuticals. Bioorthogonally activated prodrugs can exhibit significantly enhanced potency against cancer cells compared with normal cells, opening up new avenues of cancer treatment.
Carolyn R. Bertozzi, born 1966 in USA. PhD 1993 from UC Berkeley, CA, USA. Anne T. and Robert M. Bass Professor at Stanford University, CA, USA and Investigator, Howard Hughes Medical Institute, USA.
Morten Meldal, born 1954 in Denmark. PhD 1986 from Technical University of Denmark, Lyngby, Denmark. Professor at University of Copenhagen, Denmark.
K. Barry Sharpless, born 1941 in Philadelphia, PA, USA. PhD 1968 from Stanford University, CA, USA. W. M. Keck Professor at Scripps Research, La Jolla, CA, USA.