N,N-Dimethylformamide (DMF) is not a solvent above suspicion…..
N,N-Dimethylformamide (DMF) is an aprotic polar solvent very popular in organic synthesis. In many transformations, DMF is also a versatile reagent, the most commonly used being the Vilsmeier reagent. [1] In 2020, Q. Yang and Coll., from Corteva Agriscience (Indianapolis, Indiana, USA) published a very interesting and complete review, with an extensive bibliography, on the potential risks associated with the use of DMF as a solvent. [2] Numerous reports by industrial and academic researchers have clearly shown that DMF is not an inert solvent with respect to bases (NaH, KOH), acids (HCl, H?SO?), oxidizing reagents (CrO?, KMnO?, mCPBA) and reducing reagents (NaBH?). This article is particularly instructive.
[1] For an excellent recent review, see: J. Muzart, Molecules 2021, 26, 6374. https://doi.org/10.3390/molecules26216374S.
[2] Q. Yang, M. Sheng, Y. Huang, Org. Process Res. Dev. 2020, 24, 1586-1601.
Président Charles Friedel Consulting & de Chimie Paris Alumni
11 个月DMF is Aldo the main source of nitrosamine NDMA
Manager Laserax GmbH - Head of Sales Europe.
11 个月Merci pour l info Professeur. à bient?t pour un cours en direct !
Professor at Nantes University
11 个月https://www.mdpi.com/1420-3049/26/21/6374
Synthetic organic chemist working in drug discovery collaboration
11 个月The link for the molecules paper isn't working. Could you share the url again? The doi link isn't working
Organic/Peptide Chemist
11 个月La construction de diverses pyridines à partir d'un solvant commun non contr?lé est vraiment passionnante, et de nombreuses personnes seraient enthousiastes à l'idée de découvrir ces protocoles !