Newsletter Issue 18
Rehan Anjum Pharm.D, MS, BCPS, BCID.
PharmD | MS | BCPS | BCID | Clinical Pharmacist | Adjunct Asst. Professor | Pharmacy Residency Program Director | Asst. Manager Clinical Pharmacy
Gabapentin in the Treatment of Chronic Cough
Rehan Anjum (AM Clinical Pharmacy)
Gabapentin is approved for the treatment of seizures and neuropathic pain.?It is now also considered a possible therapeutic option in patients with chronic cough based on improved understanding of chronic cough pathophysiology.?
The efficacy of gabapentin was evaluated in a 10-week randomized controlled trial (N = 62), and results indicated that gabapentin (1800 mg/day) significantly improved LCQ scores compared with placebo (P?= .004). It also decreased cough severity scores (P?= .029) and objective cough frequency (P?= .028) by week 8. Once treatment was discontinued, the antitussive effects were not sustained. Current CHEST guidelines recommend a trial of gabapentin as long as patients are educated on the potential for AEs and the risk?benefit profile along with a reassessment of risk?benefit at 6 months before continuing therapy.
Reference: Gibson et.al, CHEST Expert Cough Panel. Treatment of unexplained chronic cough: CHEST guideline and expert panel report. Chest. 2016;149(1):27-44
Lecturer in Department of Pharmacy,University of Malakand,Lower Dir,Khyber Pakhtunkhwa,Pakistan
1 年Wonderful
CLINICAL Pharmacist| Drug Expert ??| Researcher?? | | Certified ? Up-to-date TRAINER
1 年Wonderful ?? it's always been intriguing to know novel treatments ???? do we prefer gabapentin when the cough becomes refractory to other therapeutic regimen?? Or we just add it with other meds ?
PharmD | MS | BCPS | BCID | Clinical Pharmacist | Adjunct Asst. Professor | Pharmacy Residency Program Director | Asst. Manager Clinical Pharmacy
1 年For the full newsletter please follow the link https://www.shifa.com.pk/wp-content/uploads/2023/05/PNL-ISSUE-18-Apr-23.pdf