News, knowledge insights, and upcoming events - October 2024
Dear reader,
As October comes to a close and autumn settles in, we’re excited to bring you the latest updates from The Hyve. This edition features important news, key insights, and information about upcoming events where you can connect with our team. Whether you’re enjoying the fall season or staying busy indoors, we invite you to explore how we’re continuing to enable open science. Happy reading!
New developments for Fairspace, our in-house tool?
Fairspace is an open-source research data management platform that adheres to FAIR principles and helps life science researchers efficiently manage and find datasets. We have made significant improvements to the user interface—check out the video to see how these updates can streamline your research process!
Highlights:
Watch this video to get a sneak peek into these new features!?
Introducing The Hyve’s Custom Open Targets Platform
?We're thrilled to introduce The Hyve's custom Open Targets Platform, which is now enriched with data and features designed specifically for researchers tackling complex diseases like cancer. This platform builds on Open Targets by integrating cBioPortal data, addressing the underrepresentation of cancer genomic information, particularly in areas like cancer omics. Dive deeper into cancer targets like never before with our enhanced platform! Read more here .
Explore more with Knowledge Graphs: We’ve also integrated our Knowledge Graph, powered by BioCypher, offering researchers a faster and more intuitive way to uncover hidden patterns and relationships between drug targets and therapies. Curious about a real-world use case? Discover how we’re mapping out new therapeutic targets for Glioblastoma Multiforme (GBM), a notoriously difficult-to-treat cancer. We’re also working on BioChatter, a new feature that combines large language models with knowledge graphs, enabling natural language queries for enhanced interaction. Learn more here .
But that’s just the beginning. Want a specific feature or dataset? We’re constantly evolving, and we want your input. Let us know what you'd like to see next!
Don't wait—test our custom Open Targets Platform and start uncovering new insights today. Access it here .
OHDSI Workshops
The OHDSI stack, a globally adopted open-source solution, enables organizations to transform large-scale real-world data into actionable evidence. Despite the availability of extensive educational resources from the OHDSI community, navigating the adoption process can be challenging. To support this journey, our workshops have trained participants from dozens of life science organizations across Europe and the U.S, helping them build expertise in the OMOP Common Data Model and the OHDSI tool suite. If your organization would benefit from this workshop, you can download the OHDSI workshop agenda here .
FAIR Maturity Matrix
The FAIR Maturity Matrix, developed by the Pistoia FAIR project, addresses the challenge of benchmarking FAIR (Findability, Accessibility, Interoperability, and Reusability) implementation across life sciences organizations. Over 20 experts from leading life science organizations, including The Hyve, collaborated to create this organizational maturity model. Designed as a self-assessment tool, the matrix consists of seven dimensions that offer diverse perspectives on FAIR implementation journeys. The seven dimensions articulate different perspectives on FAIR implementation journeys, enabling stakeholders to assess their current stage and identify concrete directions for improvement. More details about the FAIR Maturity Model can be found here.
Centralized, Federated, or TREs: Which Data Architecture Fits Your Research?
Choosing the right data collaboration architecture can make or break research success in life sciences. This article breaks down the key features and implementation considerations of centralized, federated, and Trusted Research Environments (TREs), highlighting critical aspects like data privacy, control, and scalability. Whether you’re aiming for seamless data access or prioritizing security, discover the key factors that can help you pick the best fit for your Research. Read the full article here.
Unleashing the Power of Semantic Layers: Simplifying Data Re(use) and Integration
In today's fast-paced, data-driven world, managing and integrating data from multiple sources is a common challenge, especially in pharma and life sciences R&D. Researchers need a unified view of disparate data—whether from lab experiments, clinical trials, or external literature—to answer key questions and support decision-making. A semantic layer acts as the 'glue' between raw data and user-friendly interfaces, enabling seamless integration and exploration. In this article, we explore how semantic layers solve these challenges and present two approaches to implementing an enterprise solution. Read the full article here.
Making a custom-made PANCAIM clinical data model
In collaboration with an interdisciplinary team across Europe, we designed and developed the PANCAIM clinical data model. This custom-made model was tailored to support the research goals of the PANCAIM project, a European consortium aiming to enhance pancreatic cancer treatment using AI and multi-modal data integration. The model harmonizes diverse clinical data types, allowing for effective pooling of information to train AI algorithms and improve patient outcomes. Read the full article here.
NATURE Medicine Publication demonstrating the use of consumer wearable devices to evaluate heart rate control treatment in the RATE-AF randomized trial
Our Real World Data Consultant, Julia Kurps , contributed to a Nature Medicine publication as part of the European Union Innovative Medicines Initiative? BigData@Heart program. The study explored the added value of consumer-grade wearable technology in supporting clinical research within the RATE-AF trial. By leveraging the RADAR-base platform, over two to three million data points per patient were collected, demonstrating the potential of continuous remote data collection to match conventional measures in predicting health outcomes. Read the full article here.
领英推荐
PANCAIM M45 Project Meeting in Glasgow
At the beginning of September, the PANCAIM consortium gathered in Glasgow for the M45 project meeting! These gatherings provide an excellent platform for fruitful discussions and collective problem-solving. The Hyve shared updates on the progress of the ETL implementation, crucial for our ongoing efforts in building a comprehensive data repository. As the project moves forward, we are excited about the potential of the cutting-edge AI models developed to assist clinicians in diagnosing and treating pancreatic cancer.
OHDSI Meeting at Erasmus MC in Rotterdam
OHDSI’s Dutch node gathered at Erasmus MC in Rotterdam for a collaborative meeting, facilitated by Renske Los and Aniek Markus, to drive forward the first OHDSI network study in the Netherlands. The focus is on assessing national readiness to answer clinical questions and investigating differences in patient characteristics with newly diagnosed breast cancer across data sources, including GP, registry, and hospital data. The meeting sparked interesting discussions on breast cancer incidence trends in Dutch data, and work continues to generate evidence.
BioTechX USA
BioTechX Basel 2024 brought together leading minds in the life sciences industry, showcasing cutting-edge advancements and fostering insightful discussions. One of the key highlights was Jessica Singh ’s talk, "Unlocking Cancer Insights: Harnessing Open Source Tools for Big Data in Oncology," which sparked great engagement from researchers, scientists, and industry professionals. The event also featured sessions on rare diseases and a powerful keynote panel on Women's Empowerment and Leadership in Biotechnology. These conversations highlighted the essential role of open science, FAIR data practices, and innovative tools in driving progress in life sciences.
BioTechX Europe
BiotechX Europe showcased just how far the industry has come and the exciting potential for the future, as data continues to shape the development of groundbreaking treatments and innovative products. At the event, we featured two insightful talks. Mirella Kalafati , Ph.D., Team Leader of Genomics & Targets Discovery, presented ‘Integration of Single-Cell Data Visualisation into cBioPortal for Enhanced Cancer Genomics Visualisation and Analysis’, highlighting how data visualization can advance cancer genomics research.
Wouter Franke , Strategic Consultant, had a talk titled ‘From Data to People: Seven Dimensions to Model the Maturity of FAIR Organisations’, focusing on the challenges organizations face in measuring their FAIR data practices. He introduced the FAIR Maturity Matrix, developed by the Pistoia Alliance FAIR Implementation Project. This matrix helps life sciences organizations assess their progress in implementing the FAIR Principles (Findability, Accessibility, Interoperability, and Reusability) and offers a much-needed framework for benchmarking FAIR data maturity.
Lab of the Future
The Lab of the Future Congress served as a platform for leaders in life sciences to explore the latest advances in research, development, and manufacturing. Our CEO, Harry van Haaften , and Solutions Consultant, Melissa Fernando , participated in discussions emphasizing the importance of emerging technologies and a collaborative research culture. This event focused on how these innovations can be harnessed to deliver therapeutics at pace and scale. Through curated content, lightning talks, and interactive discussions, the Congress facilitated meaningful exchanges among thought leaders from different life science organizations, fostering insights essential for the future of life sciences.
EHDEN Meeting
In October, members of the IMI EHDEN project gathered in Barcelona alongside data partners, SMEs, and key stakeholders from the regulatory and healthcare sectors. The event celebrated the project's achievements, including building a harmonized data network and advancing real-world data innovation. Our Real World Data Consultant, Julia Kurps , presented during the ‘EHDEN and Real World Data’ session, showcasing the EHDEN Portal as the entry point to this transformative ecosystem and highlighting its impact on evidence-based healthcare.
Pistoia Alliance Philadelphia Conference
12 - 13 November 2024
CYTOPHL - Phila, Philadelphia
Festival of Genomics & Biodata London
29 - 30 January 2025
ExCeL, London
If you’re attending any of these events and would like to connect, please reach out to us. We can’t wait to meet you! If not, don’t hesitate to contact us for any questions or queries about our products and services by emailing [email protected] .