NEWEST SENOLYTIC TECHNOLOGY TO REVERSE AGING NOW AVAILABLE- DISTRIBUTORS AND USERS WANTED

I am extremely pleased that I have the opportunity to now offer the newest SENOLYTIC Product and Protocol available on the market for Anti Aging and am looking for Qualified Distributors both Domestically (USA) and Worldwide. For more information on distribution opportunities please contact me directly

WHAT ARE SENOLYTICS????

A senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. A related concept is "senostatic", which means to suppress senescence.

WHAT ARE SENESCENT CELLS??? (otherwise knwon as "ZOMBIE CELLS")

Cellular senescence is a phenomenon characterized by the cessation of cell division. Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things. The physiological importance for cell senescence has been attributed to prevention of carcinogenesis, and more recently, aging, development, and tissue repair. Senescent cells contribute to the aging phenotype, including frailty syndrome, sarcopenia, and aging-associated diseases. Senescent astrocytes and microglia contribute to neurodegeneration. Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs due to various stressors. Excessive accumulation of senescent cells in numerous tissues leads to multiple chronic diseases, tissue dysfunction, age-related diseases and organ ageing

 You now have an opportunity to do something to potentially increase your health span, are you ready to fight aging with the latest science?

I am working with a company called COMBILYTICS that has developed a very effective compound and a protocol called EternLFX for SENOLYTICS containing the most effective proven ingredients to promote anit aging and removal of senescent cells from the body

Combilytics Corp natural supplements are formulated to enhance longevity

What is required for an effective natural senolytic?

1. Senolytic compounds that are known to be effective.

2. mTOR and kinase inhibitor.

3. Enhancing bio-availability.

4. Synergistic compounds.

5. Dose - taking the clinically proven dose.

6. Timing - when and how to take EternLFX.

SENOLYTIC COMPOUNDS - EternLFX contains the top 2 proven natural senolytic compounds

Quercetin – a polyphenol flavonoid is found in many fruits and vegetables, like apples and

onions. Proven in two Phase 1 clinical trials to be an effective senolytic when combined with

Dasatinib. Fisetin – a polyphenol flavonoid found in many fruits, it’s the compound that

makes strawberries red. This compound appears to be a more effective senolytic than

quercetin. The D+Q protocol - The two Phase 1 human trials that have been completed

demonstrate the combination of Dasatinib and Quercetin does clear senescent cells from the

human body. Dasatinib is a chemo drug with kinase inhibition properties. Fortunately there

are natural compounds with similar properties to Dasatinib with the extra benefit of being an

mTOR inhibitor as well. mTOR inhibition is beneficial for senolytic effectiveness Kinase inhibition

is beneficial for senolytic effectiveness

mTOR and KINASE – inhibiting your body's levels of these two families of compounds

enhances the effectiveness of senolytics. EGCG – epigallocatechin gallates is an extract of

green tea. There have been many clinical evaluations of this compound in relationship to its

ability to inhibit mTOR and certain kinases. [5] Since EternLFX won’t utilize a chemo drug, like

Dasatinib, the search began for a natural compound that would be supported by researched

properties with respect to mTOR and kinase inhibition. Green tea and more specifically, the

extract EGCG have been investigated and studied for many years in relationship to it’s many

perceived benefits. Due to this lengthy process of investigation EGCG’s properties are well

known. EGCG’s ability to inhibit mTOR is clinically documented. EGCG’s ability to inhibit certain

kinases is also well documented.

BIO -AVAILABILITY – polyphenols like Quercetin and Fisetin are notorious for having low bio

-availability, this can be enhanced. EternLFX – contains 4 natural bio -availability enhancers and

1 digestive. In searching for a solution to the low bio -availability issue, several solutions were

found. A number of natural compounds have bio -availability enhancing properties, one example of a commonly known one is grapefruit. Many medications indicate that they will be affected if consumed in conjunction with grapefruit. This is due to the way a compound in grapefruit called Naringin acts on the production of enzymes that are used to process certain drugs. There are other compounds that act on drug and supplement processing pathways. We have selected 4 of these compounds to enable better bio -availability of Quercetin and Fisetin. We often read that taking high levels of supplements is a waste, we just “excrete” the excess. While this is often true, the amount excreted can be modulated with bio -availability enhancers. For example taking turmeric on it’s own is nearly useless but add fat and pepper and it’s bio -availability will double. One of the compounds we have added to enhance bio -availability is “piperine” in the form of Ganthoda, the root of the long pepper

SYNERGISTIC COMPOUNDS – similar to bio-availability enhancers, certain compounds can have a synergistic effect and multiply benefits. EternLFX– includes alpha tocopherol, Vitamin E Both Quercetin and Fisetin can pass the blood brain barrier, they are what is termed “small molecule” compounds. Getting more Quercetin into the brain is considered a benefit as it’s known to be a powerful antioxidant as well as a senolytic at high blood plasma levels. Studies have indicated that Vitamin E enhanced the blood plasma level of Quercetin in the brain by up to 40%. [6] This increase of blood plasma levels of a proven senolytic in the brain has the potential to be of great benefit. Look up any common brain disease like Alzheimer's, Parkinson's, etc in conjunction with senescent cells and you will find good information on how senescent cells contribute to at least 15 brain related disorders. Search “Alzheimer's senescent cells”. Having Vitamin E in EternLFX is a “no brainer” DOSE - Just like pharmaceuticals, to be effective, natural compounds are dose dependent. EternLFX – the formula is designed to follow the dose levels as demonstrated in the clinical trials. This means that if you take too little or too much the effect won’t be the same as taking the clinically proven dose. For the compound Quercetin, the dose level is quite high at 20mg / kg of body weight. This means if you weigh 80kg or 176lb you need 1,600mg of the active ingredient used in the trial. per day of the cycle. NOT 100mg a day or 500mg a day. Two Phase 1 human trials indicate the combination of Dasatinib and Quercetin do clear senescent cells from the human body. With respect to Fisetin and the planned Phase 1 trial, the specified dose of 20mg / kg of body weight of the active compound is the same as used in the D+Q trials. [4] Being aware of the actual active ingredient level is important. The level of compound activity is indicated typically by a percent of content as in “Fisetin 50%” or “Fisetin 98%”. This indicates that it would take twice as much of the 50% version, compared to a 100% version, so 3,200mg vrs 1,600mg

TIMING - to be effective pharmaceuticals are prescribed with specific timing of consumption.

This is no different for natural compounds. EternLFX– the formula is designed to follow the

timing cycles demonstrated in the Phase 1 clinical trials. The term “hit and run” was used in some trials for the timing protocol. The compounds are used in 3 day cycles, for 1, 2 , 3 or 4 weekly cycles and then a period of time without any consumption of the compounds. With EternLFX we follow this protocol with a 4 week program that has 4 weekly cycles of 3 days on and 4 days off. We use the term cycles to describe Combilytics version of “hit and run”. When senescent cells are “cleared” they are induced into cellular death or apoptosis. This leaves the bodies systems to clear up the detritus that is left over, or a “housekeeping” period. During this time off, the body will be stimulated to replace the cleared cells with functional replacements, thereby enhancing the healing effect.

THIS TECHNOLOGY IS A GAME CHANGER AND ANYONE INVOLVED IN ANTI AGING, REGENERATIVE MEDICINE, AESTHETICS CAN CONTACT ME FOR MORE INFORMATION ON THE SCIENCE AND THE OPPORTUNITY. INBOX ME OR CONTACT ME DIRECTLY AT [email protected]

JONATHAN SCHWARTZ

CEO, MEDICALMARVELS LLC

medicalmarvels @yahoo.com