Newcells Biotech Newsletter
Focus On: Newcells Capabilities
At Newcells Biotech we build functional in vitro models to improve clinical translation and drug discovery. We are cell biologists, tissue physiologists and assay development scientists focused on building models that balance complexity, functionality and throughput to improve the predictive power of in vitro data. We aim to contribute to the development of new innovative therapies by delivering services, products and tools that provide data that predicts how these therapies will behave in humans. Our products and services enable customers to rapidly evaluate the efficacy, safety and molecular transport to de-risk discovery and development.?
Meet Our Head of Retina Development:
Dr Valeria Chichagova
We are thrilled to introduce you to one of the leaders behind our ground-breaking progress in retinal organoid and RPE model development here – Dr Valeria Chichagova.
Under Valeria's leadership, our retinal organoids have developed into the leading in vitro tool for studying retinopathies, evaluating gene therapies, and assessing drug efficacy.? With a commitment to advancing scientific knowledge and improving patient outcomes, Valeria's work resonates with our mission to push the boundaries of in vitro cell-based models. The retina team’s expertise is paving the way for us to create models that are more relevant to human physiology, and more predictive to bring our clients more efficient tools to accelerate research and therapeutic development around the retina.?
We invite you to connect with Valeria on LinkedIn to stay updated on our latest developments and explore the cutting-edge technology we continue to innovate Watch Valeria in our latest video, showcasing our expertise in retinal model development here at Newcells.
Reminder:
Explore ADC Toxicity Testing with Our Advanced In Vitro Models
At Newcells Biotech, we are continuously expanding our capabilities to support your drug discovery and development journey. For example, did you know that we have harnessed the power of our aProximate? human proximal tubule model to evaluate the toxicity of antibody-drug conjugates (ADCs) in vitro?? Our aProximate? model mimics in vivo renal physiology expressing all essential renal transporter classes, including the megalin/cubilin transporters, making it an ideal platform for assessing both small and large molecule safety and transport dynamics. Our commitment to providing advanced in vitro tools extends beyond the kidney. Our in vitro lung models replicate the intricate interactions between the cells found in the airway epithelium, allowing us to model the effects of compounds such as ADCs and disease processes such as fibrosis. Using our ophthalmology platform, we can combine our human-derived retinal organoids and retinal pigmented epithelium (RPE) to assess ocular toxicity associated with ADCs, which is a known potential issue with some therapies.? With Newcells, you gain access to a comprehensive suite of in vitro models that offer deeper insights into the safety and efficacy of your ADC candidates. Reach out to us today to learn more about how our innovative models can enhance your ADC toxicity testing strategies and provide valuable data for your drug development pipeline.
Discover our latest resources on our website
We are continually adding new resources on our website to keep you up to date with all of our latest developments. Come and browse through our publications, posters, videos and comprehensive eBooks!
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Latest Innovation:
Lung, Small Airway Epithelial Cell Model
We recently launched our Human Small Airway Epithelial Cell (SAEC), Air-Liquid Interface (ALI) model. With these cutting-edge models, we aim to provide customers with a range of models and assays to improve drug discovery projects targeting or affecting the lung. We have focused on developing and validating assays that can provide high-throughput (384-well format) readouts or high-content data using the latest imaging technologies.?
Our in vitro human lung SAEC model fills a crucial gap in lung research. It allows us to explore lung physiology, study drug toxicity, and assess responses to epithelial damage, all within a controlled and validated model system.? As we continue to collaborate with leading pharmaceutical and biotech companies, Newcells is becoming a trusted partner for cutting-edge lung research. The SAEC model's capabilities enable swift and comprehensive experimental design drastically reducing the time required to reach meaningful results. With our expertise and our innovative model, you can accelerate your research significantly. Contact us today to talk to our leading lung expert and to explore how our services can positively impact your lung-based project timeline.
领英推荐
Come and meet our leading scientists
25th American ISSX Meeting
?10th September - 13th September, 2023
4th Annual Gene Therapy for Ophthalmic Disorders
3rd October - 5th October, 2023
Coming Soon: Introducing Our Complex Glomerulus Model!
We're excited to share a sneak peek into our latest development: a complex model of the glomerulus, featuring the integration of endothelial cells. This advancement marks a significant step forward in our pursuit of more accurate and comprehensive in vitro kidney models.
We're excited to leverage our expertise to introduce this novel multi-cellular model, which promises to offer a more physiologically relevant representation of renal physiology.
Keep an eye on our upcoming newsletters and announcements for more insights into this exciting development or get in touch today to find out more!
Interested to know more about Newcells Biotech and our amazing team of industry experts? Visit our website to find out more about our?in vitro?models
Retina Models
Models of the retinal neuro- and pigmented epithelium for use in modelling of retinopathies and safety studies. Find out more
Kidney Nephron Models
Used in combination or separately, our models of the glomerulus, proximal tubule and TAL give you an unprecedented ability to measure how your drug effects the kidney. Find out more
Lung Airway Models
A suite of models for studying fibrotic disease mechanisms in the lung enabling candidate screening and efficacy studies. Find out more