The Neuroscience of Purpose: How Contributing Makes Us Better
Zach Mercurio, Ph.D.
Author, “The Power of Mattering" (May 2025) & “The Invisible Leader” | Speaker & Facilitator on Purposeful Leadership, Mattering, & Meaningful Work | Adjunct Professor & Researcher @ Colorado State University
“Man’s main concern is not to gain pleasure or to avoid pain but rather to see a meaning in his life. That is why man is even ready to suffer, on the condition, to be sure, that his suffering has meaning.” — Viktor Frankl
A cold April rain swept across the puddled Boston streets as Desiree Linden became the first American woman in over 30 years to win the Boston Marathon.
As she waved the American flag with a beaming smile, you’d never know she’d been moments away from quitting.
Yes, quitting.
In a post-race interview, Linden disclosed that early in the race she was “feeling horrible.”
That was until she made the decision sports psychologists and neuroscientists say likely gave her the boost she would need to win the race: She stopped thinking about herself.
Knowing she would likely drop out of the race, Linden saw a struggling fellow runner, Shalene Flanagan, and decided to offer help.
According to Runner’s World Magazine, Linden said to Flanagan, “If you need anything — block the wind, adjust the pace maybe — let me know.”
Shortly after she started helping, Linden says she remarkably “got her legs back.”
“Helping her helped me,” she said.
The rest is, quite literally, history.
Linden’s remarkable run in the face of adversity is a lesson on what can happen to us — in life, work, or school — when we are pulled by a purpose beyond ourselves.
Inspirational anecdotes like Linden’s are plentiful. So plentiful that it’s easy to overlook the mounting scientific evidence that supports them and the power of purpose.
Quite simply, having a sense of purpose makes us neurologically and physiologically better — at work, in school, and in life.
Here’s how:
Purpose focuses our attention on others.
Purpose is defined as “the reason for which something is done or created or for which something exists.”
In other words, our purpose as individuals or as an organization is our usefulness, our contribution.
The ability for purpose to lift our eyes off ourselves is what makes it so powerful in enhancing both personal and organizational performance.
Two recent studies from UCLA’s Semel Institute of Neuroscience have identified a part of the brain, the posterior superior temporal cortex, that seems to be hard-wired for contribution.
Why?
Researchers hypothesize that altruism has allowed us to survive as a species by compelling us to help one another.
And when we do, such as in Linden’s case, we reap the neurological and physical rewards — which in turn induce more altruistic behavior.
The reward of helping comes in the form of a rush of oxytocin, dopamine, and serotonin — what neuroscientists call the “happiness trifecta.” Oxytocin supports empathy and social bonding. Dopamine plays a major role in motivation and movement. Serotonin regulates mood.
Another side effect of serving others is increased endorphin production. According to a study published in the Hawai’i Medical Journal, endorphins act like a “natural morphine,” reducing pain and improving performance.
Considering the evidence, when we read about the benefits of purpose in organizations, we must remember that organizations are simply individuals who organize.
It’s not surprising, then, that when individuals in organizations are compelled by an other-centered purpose they feel happier, are more motivated, form better teams, and perform better.
And the scientific evidence underscores that the desire for purpose is not a trend, we’re hard-wired for it.
Purpose activates resilience and protects your brain.
Adding to the benefits on mood, motivation, and movement, purpose can also make us biologically more resilient.
In a groundbreaking study, neuropsychologist Dr. Patricia Boyle and her colleagues at Rush University followed over 900 older people who were at risk for dementia. After controlling for other potential influencers, participants who identified a purpose in life outside of themselves were only half as likely to develop Alzheimer’s.
Though they don’t know “how” yet, follow-up studies have suggested that having a purpose affects “cognitive reserve,” or the biological strength and resilience of the brain cells to injury and degradation.
And what happens to us neurologically influences what happens to us physiologically.
One landmark study found that a strong sense of purpose resulted in a 72 percent lower risk of a stroke and a 44 percent lower rate of cardiovascular disease.
A key mechanism of building biological grit and resilience — whether you’re running a Fortune 500 company, working a normal job, or finishing a degree — is a strong sense of an other-centered purpose.
Purpose, not happiness, provides enduring fulfillment.
Here in the U.S. we’re taught in the Declaration of Independence to pursue happiness, but we may be cheating ourselves out of long-term fulfillment if happiness, pleasure, or security are our sole goals in life, school, or work.
“The pursuit of happiness receives a lot more attention in our culture than the pursuit of meaning or purpose,” says Dr. Adam Kaplin, a Johns Hopkins University psychiatrist. “A purely happy person is primarily concerned with the present and instant gratification of their own needs. A person who pursues a chiefly meaningful life is more likely to contemplate the past or future and be concerned about others’ well-being.”
While happiness may give us pleasure and reduce stress and worry, researchers find it’s temporary.
Extrinsic, pleasure-inducing rewards like a job title, a degree, a pay increase or salary, simply give us fleeting “pushes.”
Purpose, because it’s rooted in something outside ourselves, constantly pulls us forward and through difficult times.
When we’re pulled by purpose, we’re more likely to reflect on our past and future, and are much more likely to regularly consider our impact on others.
And that brings us full circle: When we serve others, we become better.
More importantly, we transcend ourselves and become part of something bigger.
Which, as Desiree Linden learned, may be more important than acquiring or achieving any “thing.”
“Today was bigger than one person,” Linden said after her win. “It was really all of us pushing each other.”
Zach Mercurio is a purpose and meaningful work consultant, researcher, and bestselling author of “The Invisible Leader: Transform Your Life, Work, and Organization with the Power of Authentic Purpose.”
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HR Manager @ Technogym Australia
4 年Thank you Zach Mercurio! Just listened to your talk at #onpurpose and I loved it. I will start with the small steps :) Great insights in this article, fascinating!
Speaker, Author, High Energy Workshop Facilitator, Certified Chief Happiness Officer and Muse helps you increase performance, productivity, wellness and, of course, employee and customer loyalty.
4 年Great article Zach. Really touched home - yesterday would have been my Mom's 101st birthday. She's a woman who would have made that milestone except for one thing. At the age of 91 my lost her job. She was a Supreme Court Justice in NY and when she was 91 the new governor disbanded the department she worked for that allowed retired judges to continue sitting on the bench. She adored her work and her work family. After they were disbanded, she started going downhill. She lost interest in playing card with her friends and eventually we asked her to stop driving so the shopping for bargains she used to do stopped too. While we tried to get her to write a book - her adventures as a divorce lawyer for 35 years before coming a judge were the stuff of tabloid intrigue - she couldn't muster the energy. This amazing woman, who physically was 15 younger than her years - went downhill fast. All she could say was "I have no purpose." It was heartbreaking. She had kids, grandkids and even great grands but none of that took the place of the purpose she felt as a judge. She died at 93 and I know without a shadow of a doubt that had she still felt that purpose - she easily would have made it to 100!
Thanks for sharing this! As a political science student, I've always wanted to find something that articulates this succinctly yet backed by empirical evidence. If I may share an anecdote, I've family friends who became quite physically weak and distraught after their other half passed on but they literally sprang to life when they had a new found purpose such as taking care of a newborn grandkid!
As a purpose advocate coach and lecturer- Simply loved your article- clear and concise. As Nietzsche said- “He who has a why to live by can endure any How”- it is not the pursuit of happiness that is important but the pursuit of the complements of happiness- like purpose and the perseverance, positive outlook physical wellness and people focus needed to make it happen:)