Neuroprotective Potential of NR in Ameliorating CCH-Induced Cognitive Impairment
Chronic cerebral hypoperfusion (CCH) has been identified as one of the initial conditions critical to the development of cognitive impairment, which is tightly associated to the complex neurological disorders such as Alzheimer's disease and vascular dementia (VaD).
Currently, there is a multitude of research studies focused on the treatment of Alzheimer's disease, but there are still no effective treatment options available for CCH-related VaD. Notably, nicotinamide riboside (NR), a precursor of NAD+, can ameliorate CCH-related VaD, exerting a neuroprotective effect.
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