The Natural Extract That Delays Aging and Extends Healthspan

Aging is a complex, multi-stage, and progressive process that unfolds over the entire lifespan. As time passes, the organs and muscles in the human body gradually age, and a range of age-related diseases such as cancer, diabetes, and cardiovascular conditions often emerge.

Increasing research points to the remarkable potential of plant-derived compounds—including polyphenols, flavonoids, and terpenes—in extending healthy lifespan through mechanisms like antioxidation and activation of mitochondrial autophagy. These compounds exhibit promising anti-aging properties.

Salvia haenkeinbsp;Extract: A Natural Ally Against Aging

Previous studies have demonstrated that Salvia haenkei?extract can delay aging in vitro, significantly reducing the number of senescence-associated β-galactosidase-positive cells in both mouse and human models, showcasing its anti-aging properties.

A recent study by researchers from the University of Padua, published in the journal Nature Aging, titled "Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice," further explores this potential.

Study Highlights

The study reveals that daily intake of sage extract can extend the lifespan and healthspan of mice, suppressing age-induced inflammation, fibrosis, and senescence markers across various tissues, thereby improving aging phenotypes.

Researchers analyzed the anti-aging potential of Salvia haenkei (Haenkenium (HK))?in a mouse model by incorporating a low dose of HK into the daily drinking water of mice. They monitored the accumulation of senescent cells and various aging-related parameters, including lifespan, physical health, fibrosis, bone mineralization, and inflammation.

Twenty-month-old mice were given HK-treated water until their natural death. The findings were remarkable: the average lifespan of HK-treated mice was 32.25 months, compared to 28 months for the control group—an extension of 4.25 months. Both male and female mice experienced significant lifespan extension.

Histopathological analysis of the skin, liver, kidneys, and lungs indicated that HK treatment did not alter hematopoietic parameters or cause organ toxicity, affirming its safety.

Key Findings

· Improved Aging Phenotypes: HK treatment improved aging phenotypes such as hunchback, tumor development, and fur condition.

· Safety and Efficacy: No observed toxicity with HK treatment, affirming its safety.

· Healthspan Extension: Enhanced physical health and reduced markers of aging in various tissues, including improved hair, skeletal and muscle health, and kidney function.

Mechanisms of Action

Mechanistic analysis revealed that HK treatment significantly downregulated the SAUL_SEN_MAYO senescence gene set, while upregulated genes were associated with inflammation, immune activation, and senescence-related pathways. Additionally, HK treatment lowered senescence marker levels across different tissues.

Chemotherapy-Induced Senescence and Toxicity

Beyond natural aging, HK treatment also prevented chemotherapy-induced senescence and cardiac toxicity caused by the drug doxorubicin, while maintaining its therapeutic efficacy.

Active Components

Further analysis identified luteolin, a flavonoid, as the active component responsible for HK's anti-aging effects. Luteolin improves senescence by modulating the interaction between p16 and CDK6.

Conclusion

This groundbreaking research unveils a natural extract with potent anti-aging properties, capable of alleviating cellular and tissue senescence and improving age-related symptoms. Salvia haenkei?extract extends lifespan and healthspan without observed toxicity, marking a significant stride in the quest for anti-aging solutions.

Reference

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice.