Nanotoxicology: Tissue Engineering and Regenerative Medicine by PK Gupta
Dr Pawan Kumar (PK) Gupta
President, ASAW; Director, Toxicology; formerly Div Head, IVRI Advisor WHO; Editor/Author/Expert WHO, UNFAO and IAEA
Abstract
Tissue engineering and regenerative medicine (TERM) is a biomedical engineering discipline that uses a combination of cells, engineering, materials, methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. TERM often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds. This chapter covers the rationale of tissue engineering; the latest innovations; applications of nanoparticles; use of nanomaterials; delivery of bioactive agents/molecules (growth factors, chemokines, inhibitors, cytokines, genes, etc.); use of contrast agents in a controlled manner; their biocompatibility; toxicity; and safety aspects that are important implements to exert control over and monitor during TERM.