Nanomedicine in Immune System Therapy P K Gupta

https://link.springer.com/chapter/10.1007/978-3-031-24287-8_10

Abstract

With the advent of nanotechnology, the prospects for using engineered nanomaterials (NMs) with diameters of <100 nm in industrial applications, medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and other areas have progressed rapidly. The potential for NPs in these areas is infinite, with novel applications constantly being explored. The possible toxic health effects of these NPs associated with human exposure are unknown. As a result of acquired cellular damage, NPs can induce different pathways of programmed cell death, including apoptosis, regulated necrosis, and autophagic cell death. Although immunotherapy has made significant advances, the clinical applications of immunotherapy encounter several challenges associated with safety and efficacy. This chapter deals with immunotherapy to improve the ability of immunomodulatory molecules to reach disease tissues, immune cells, or their intracellular compartments, in the context of chronic immune disorders and health problems associated with the use of nanotechnology.

Keywords

• Nanotechnology, Drug delivery, Immune system, Cancer immunotherapy, Nano-immuno-oncologicals, Nano-immunotherapies, Autoimmune disease, NPs, Immunosuppression, Nanotoxicology, Immunotoxicity, Anti-Inflammatory, ImmunostimulationFurther Reading

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