Multiplex Respiratory Tract Detection (Including hMPV) - Enabling Precise Diagnosis

In the winter of the northern hemisphere, acute respiratory infections have increased across several countries, caused by pathogens like seasonal influenza, respiratory syncytial virus (RSV), human metapneumovirus?(hMPV), and Mycoplasma pneumoniae?(MP). The WHO noted that this trend is not unexpected but urged preventive measures. In Japan, the average number of reported influenza cases in the last week of 2024 was almost three times that of the same period last year, marking the highest in a decade. In the U.S., human cases of highly pathogenic avian influenza H5N1 are rising, with the first death reported. Influenza cases have surged in regions across Europe, Central America, the Caribbean, West and Central Africa, and Asia, with varying prevalent strains. RSV and hMPV?also show regional differences, with new outbreaks reported in India, South Africa, China, and elsewhere.

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Source: https://www.who.int/emergencies/disease-outbreak-news/item/2025-DON550

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How to prevent respiratory tract infections?

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• Maintain personal hygiene. Wash hands frequently. Cover the mouth and nose when coughing or sneezing, and wash hands promptly afterwards.
• In crowded places, keep a distance of more than 1 meter from others and take proper protective measures.
• For pathogens with available vaccines, get vaccinated accordingly.
• Enhance immunity by maintaining a balanced diet, getting sufficient sleep, and strengthening exercise.
• Keep indoor air ventilated.

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Although there are no specific drugs for some infections, treatment approaches vary significantly depending on the pathogen.

• Viral Infections (e.g., Influenza, COVID-19, Common Cold):

Influenza: Oseltamivir (effective within 48 hours of symptoms).

COVID-19: Nirmatrelvir/ritonavir tablets for severe cases, along with supportive care.

Common Cold: No antiviral treatment; symptom relief with rest, hydration, and medications like paracetamol (for fever) and pseudoephedrine (for nasal congestion).

• Bacterial Infections:

Pneumonia (Streptococcus pneumoniae): Penicillins or cephalosporins. If allergic, use respiratory quinolones like moxifloxacin.

• Mycoplasma Infections:

Respiratory Infections (Mycoplasma pneumoniae): Macrolides (e.g., azithromycin, erythromycin).

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Detection Methods for Respiratory Tract Infection Pathogens:

• Pathogen Culture: Involves culturing specimens (e.g., sputum, blood) to identify pathogens and test drug sensitivity. Virus culture is complex and slow, while bacterial culture takes 24-48 hours or more.
• Antibody Detection: Detects specific antibodies in blood to identify past infections. Mainly used for epidemiological studies and retrospective diagnosis, with positive results appearing after some time.
• Antigen Detection: Uses immunological methods (e.g., immunofluorescence, colloidal gold, ELISA) to detect pathogen antigens in specimens. It's quick but less accurate.
• Nucleic Acid Detection: Includes PCR and other techniques to detect viral or bacterial DNA/RNA in specimens. Methods like real-time PCR, multiplex PCR, and gene sequencing are highly sensitive and specific.

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Nucleic acid testing is considered the gold standard for diagnosing various infectious diseases, as recommended by the WHO.

To enhance detection efficiency?and accuracy, while minimizing errors and misdiagnosis, Macro&Micro-Test has developed advanced solutions. For instance, the 14 Kinds of Respiratory Viruses Nucleic Acid Detection Kit (Fluorescence PCR)?enables precise detection of 14?common respiratory pathogens simultaneously.

• Wide Coverage: Detects 14 common respiratory pathogens including?Covid-19, Flu A &B,?RSV, Adv, hMPV, Rhv, PIVI/II/III/IV, HBoV,?EV, CoV, MP, Cpn,?SP?in oropharyngeal/nasopharyngeal swab?samples.?
• High Sensitivity: Detects?as few as 200 copies/ml, enabling early-stage detection.
• High Specificity: Minimizes cross-reactivity with other pathogens, reducing misdiagnosis.
• Fast Results: Provides accurate results within just 40 minutes.
• Strong Compatibility: Works with various mainstream PCR systems for seamless integration.

The Multiplex Syndromic Respiratory PCR Testing offers a comprehensive approach to diagnosing multiple respiratory pathogens in a single test. By detecting a wide range of viruses and bacteria, it provides rapid, accurate results that help clinicians make informed decisions, leading to timely treatment and better patient outcomes.

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Stay informed-?let the Precise Diagnosis Shapes A Better Future. Contact [email protected]?to enhance your diagnostic capabilities.

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