MTAP Loss in Advanced Gastrointestinal Cancers

I'd like to thank Dr. Jordi Rodon Ahnert, ICT fellows Dr. Natalie Ngoi and Catia Gaspar, and our study collaborators for including me in a description of the frequent loss of the MTAP gene, which is adjacent to the CDNK2A (p16INK4A/p19ARF) gene, in GI cancers as well as in roughly half of gliomas and glioblastomas. Characterizing the reproductive phenotypes of mouse knockouts of the INK4 and CIP/KIP families of CDK inhibitors was the focus of my graduate work, so it was a nice tie-in to my former expertise. My major contribution to the paper was providing clinical data annotation and extraction from the MOCLIA database.

Natalie Y L Ngoi, Tin-Yun Tang, Catia F Gaspar, Dean C Pavlick, Gregory M Buchold, Emma L Scholefield, Vamsi Parimi, Richard S P Huang, Tyler Janovitz, Natalie Danziger, Mia A Levy, Shubham Pant, Anaemy Danner De Armas, David Kumpula, Jeffrey S Ross, Milind Javle, Jordi Rodon Ahnert. MTAP loss Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers. The Oncologist, oyae011, Published: 08 February 2024. https://doi.org/10.1093/oncolo/oyae011

Link to the paper on The Oncologist