Mouse Biospecimen Management at University of California (Davis)

The??Mouse Biology Program?(MBP) of the?University of California, Davis (UCD)?is the largest academic program in the world. MBP is a member of the NIH-funded?Mutant Mouse Resource and Research Centers (MMRRC). The network collects and characterizes gene-modified and genetic knockout lab mice and makes them available to 800 researchers at over 400 institutions in 42 countries around the globe. [1]

Tumor samples are surgically resected from participants consenting to the U54 study and implanted to mouse models in MBSR (Mouse Biology Shared Resources). The biospecimen is allowed to grow in the mouse in a sterile controlled environment and are sent back to UCD for QA (Immunohistochemistry and KI67 staining).

The data is recorded in OpenSpecimen biobanking LIMS throughout the process.

“We could not have tracked the outgoing U54 participant specimens and the incoming U54 PDX models without OpenSpecimen’s high degree of configurability. Data entry is smooth and straightforward. For easy access to data, I have set up pivot tables showing the number of specimens per PDX model plus tumor site and passage.” said?Irmgard Feldman,?Biorepository Manager?at the Department of Pathology and Laboratory Medicine at UC Davis.

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