Monthly Biotech News Discussion: January 2025 in Review
1.????? New Modalities：
????? Sana announces positive clinical results from type 1 diabetes study of islet cell transplantation without immunosuppression; (Jun, Ashley, Yanran)
????? After Novo Nordisk and Biogen, AbbVie became San Diego biotech Neomorph’s third partner in developing molecular glues; (Hong Yue)
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2.????? Oncology & Autoimmune Diseases：
????? JNJ’s Amivantamab plus Lazertinib showed statistically significant and clinically meaningful OS improvement vs. Osimertinib in 1L locally advanced or metastatic?NSCLC with EGFR mutations；(Sean Yao)
????? Eli Lilly acquired Scorpion’s mutant-selective PI3Ka inhibitor program for $2.5B;? (Leon Tang)(Haoran Wang)
????? IGM Biosciences halted development of 2 bispecific T cell engagers for autoimmune diseases; (Jun)
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3.????? Metabolic & Neurological Diseases：
????? Akero Therapeutics reported positive phase 2b results of bivalent FGF21 analog Efruxifermin in MASH patients with biopsy-confirmed compensated cirrhosis; (Ethan)
????? JNJ acquired Intra-Cellular for $14.6B to double down on neurological diseases; (Ethan)
????? Vigil Neuroscience’s TREM2-targeted VG-3927 in phase 1 Alzheimer's trial, moving on to phase 2；(Haoran, Jun)
????? Neumora’s Navacaprant failed the first of three major depression phase 3 trials；(Haoran Wang)
Date:?Saturday, Feb 01, 2025
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