Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: 20 September 2025Special Issue Information

Dear Colleagues,

Recent advancements in gut microbiota research have revealed its pivotal role in maintaining host health, influencing not only metabolism but also immune regulation and neurological functions. This Special Issue aims to explore how diet, probiotics, and circadian rhythms collectively shape gut microbiota composition and function, contributing to overall health and disease prevention.

The focus of this Special Issue is on the interplay between dietary interventions and microbiota modulation, with a specific emphasis on the role of functional foods, probiotics, and prebiotics in promoting a balanced microbiome. Additionally, it will delve into the emerging field of circadian biology, highlighting how the synchronization of circadian rhythms with microbial and metabolic processes impacts health outcomes.

The scope of this issue spans experimental and clinical studies that investigate the molecular mechanisms underlying diet–microbiota–host interactions. Submissions are invited on a broad range of topics, including the following:

• Nutritional strategies to enhance microbiome diversity and resilience.
• Probiotic applications in gut health and host–microbe dynamics.
• The role of microbial metabolites in circadian regulation.
• Microbiota-mediated pathways linking diet to metabolic and neurobehavioral health.
• Host–microbe interactions in models like intestinal organoids or C. elegans.

The purpose of this Special Issue is to provide a comprehensive platform for advancing our understanding of the gut microbiome as a dynamic regulator of health. By encouraging interdisciplinary contributions, we aim to bridge the gaps between microbiology, nutrition, and chronobiology, offering innovative perspectives for therapeutic interventions targeting the microbiome.

This Special Issue is an excellent opportunity for researchers to share cutting-edge findings and contribute to a growing field with immense translational potential. We welcome high-quality original research, reviews, and methodological papers.

Dr. Miri Park

Dr. Jeehwan Choe

Guest Editors

Keywords

• gut microbiota
• diet and microbiome
• probiotics
• prebiotics
• circadian rhythms
• microbial metabolites
• host–microbe interactions
• nutritional strategies
• gut–brain axis
• metabolic health

More Info: https://www.mdpi.com/journal/metabolites/special_issues/VA0KM2OTQL