Metal-conjugated #antibodies (with technology) can stratify #tumors for #personalizedmedicine:
"We have provided a high-dimensional spatial map of the brain tumor microenvironment using imaging mass cytometry (IMC). We performed a comprehensive analysis of cellular dynamics, interactions and neighborhoods in glioblastoma and brain metastases, and correlated spatial features of glioblastoma with patient survival. We defined multicellular structures that are common across disease states and regions, which are superior for predicting patient survival compared with cell frequencies alone."
"These analyses revealed cellular neighborhoods associated with survival in patients with glioblastoma, which we leveraged to identify a unique population of myeloperoxidase (MPO)-positive macrophages associated with long-term survival."