Medllecta: Hematological preventive method (HPM). Part 2.

Abstract.

A complete dynamic model of the protein and, in particular, the enzymatic process of synthesis and degradation could significantly improve the quality of diagnosis of diseases of various etiologies at the earliest stages of their development. In this article, we describe our initial attempt to create the above model based on a radically new mathematical approach, Sense Logic [1] in terms of enzymatic kinetics.?

1.Introduction

In a rough approximation, the human body can be represented as a topological space where any organ or internal system is open sets with the exception of the skin. The topology of this space, in this case, is the set of all internal systems of the human body. Accordingly, in order to diagnose the general state of the human body at a certain moment in time, we must clearly understand the principles of interaction and influence on each other of all internal systems of the body (systems of subsets of topology) of a person at a given moment in time. However, the tools of traditional mathematics do not provide any physiological or pathogenetic interpretation in terms of, for example, the products of an enzymatic reaction. They also do not provide any tools for constructing models of protein metabolism leading, say, to autoimmune diseases.

For the purpose of the possibility of constructing the above models, as well as hematological patterns corresponding to a certain pathophysiological process of the human body, below in this article we use the Sense Logic of the theory of the Sense Theory.?

2.Problem

Lack of a unified mechanism (instrumentation) for constructing a complete dynamic pathophysiological model of the human body with the ability to identify the primary source of protein transmutation.

3.Solution

One of the main mechanisms in determining the organ source of pathogenesis is the analysis of the biochemical processes of plasma proteins and amino acids.?

Plasma proteins.

The vast majority of all pathophysiological processes in the human body occur with the direct participation of proteins. In practical (clinical) medicine, plasma proteins are usually classified according to their functionality [3]:

Table 1. (see Appendix)?

The total concentration of proteins in blood plasma depends on three main factors:

1. the volume of protein synthesis at the sites of their production

2. the proportions of their distribution in the human body

3. the rate of their elimination from the human body

For diagnostic purposes, it is advisable to take into account all possible factors that directly or indirectly affect the concentration of human blood plasma proteins. Among them [3]:?

Physiological factors

Age. the age of a person affects the numerical and qualitative indicators

Gender. α-fetoprotein, ferritin, IgM

Drugs. oral contraceptives, testosterone, phenothiazines, estrogens

Genetic characteristics. phenotype, individual proteins

Nutrition. the complement system, prealbumin, retinol-binding protein

Pregnancy. transport proteins, α-fetoprotein

Physical exercise. increase in protein concentration

Environment. immunoglobulin level

Pathological factors

Losses. damaged organ, nephrotic syndrome, glomerular proteinuria, tubular proteinuria

Synthesis. liver disease, phenotypic deficiency

Volume circulating blood. hypohydration, overhydration

Catabolism. inflammation

Disposal speed. kidney disease, inflammation

Compensatory mechanisms. nephrotic syndrome

Methodological factors

Storage. proteolytic enzyme activity

Laboratory methods. different permissible error

Sampling method blood. concentration change

With the damage of any etiology, the process of inflammation begins in the human body.

“Dysfunction of internal organs and systems of the human body is always an inflammatory process”

The process of inflammation itself can be divided into acute and chronic.?

The concentration of acute inflammation proteins, the so-called acute phase proteins (APPs), changes during the first 6-48 hours. The acute phase can last for several days, depending on the duration of the action of the damaging factors. There is a direct correlation between the concentration of acute-phase proteins and the phases of disease activity. In this regard, the indicator of the concentration of acute-phase proteins can be used to monitor the course of the disease.

For example, it is possible to classify some proteins of the acute phase on the basis of multiple increases in their concentration over time [3]:?

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