Medicilon Preclinical Models for Psoriasis

World Psoriasis Day is a global awareness day held every year on 29 October, which aims towards increasing knowledge of the existence and impact of inflammatory and autoimmune diseases.

Psoriasis is a chronic inflammatory skin disease associated with multiple contributing factors including autoimmune dysfunction. Psoriasis leads to the alteration of skin components which generally manifests as unwanted topical symptoms.

Medicilon has effective models for evaluating drugs for psoriasis.

Psoriasis Model Induced by Imiquimod——

Psoriasis is a chronic inflammatory skin disease associated with multiple contributing factors including autoimmune dysfunction. Psoriasis leads to the alteration of skin components which generally manifests as unwanted topical symptoms. One of the most widely approved psoriasis-like animal models is the Imiquimod (IMQ)-induced mouse model. The IMQ-induced Psoriasis model is particularly translational into the clinic as it has many of the significant markers of human disease, including histopathology of lesions and strong activation of the immune system. IMQ is a ligand for Toll-like receptors 7/8 which activates macrophages, monocytes and dendritic cells.

Topical application of IMQ can induce psoriasis. It is a rapid and convenient model that allows the elucidation of underlying mechanisms and the evaluation of new therapies against psoriasis.

IL-23 Induced Mouse Auricle Psoriasis Model——

IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is produced by various immune cells and stimulates the activity of Th17 cells. Th17 cells, in turn, produce cytokines that promote inflammation and recruit immune cells to the site of infection or injury. The IL-23/IL-17A pathway plays a critical role in psoriasis. IL-23 is a key cytokine produced by antigen-presenting cells that is necessary for the development of pathogenic IL-17A-secreting lymphocytes. IL-17A and other cytokines drive the abnormal differentiation of keratinocytes and inflammation that lead to the manifestations of disease.

IL-23-induced psoriasis mouse model is the most prevalent among psoriatic mouse models due to its ease of use, convenience, and low cost. IL-23 induced psoriasis mouse mode is provoked by IL-23 intra-dermal injections produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. The IL-23 injection model has the advantage of using a single cytokine that is of established importance in psoriasis in initiating inflammation.

Keeping pace with industrial development and market demand, Medicilon's experienced Pharmacology and Pharmacodynamics Department has established a complete animal model evaluation system based on verification, precision and efficacy testing. Medicilon provides test subjects that include non-human primates, dogs, rats, mice, rabbits, guinea pigs, and miniature pigs.

With more than 20 years of experience, Medicilon boasts 270+ evaluation models for non-tumor diseases, including inflammatory & immune, CNS, digestive, metabolic, cardiovascular and others.

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