Med. Chem. Res. 2025, Vol 34, Iss 1

Medicinal Chemistry Research | 2025 | ?Volume 34, Issue 1, ?is now available online.

In this issue

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Review Article

Structural modifications of berberine and the lipid-regulating effects of its derivatives

Yun Lu, Mengxuan Yin, Yuting Lai, Xinyi Ye, Meiling Chen, Yubo Li

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Review Article

Multi-targeted pharmacological properties of cinnamyl piperazine derivatives: a comprehensive review

Yongqi Wang, Mengchen Lei, Zefeng Zhao, Shaoping Wu, Xiaohui Zheng, Haifa Qiao, Xiaohang Yang

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Review Article

Naturally occurring organosulfur for treating metabolic disorders and infectious diseases

Gautam Kumar

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Review Article

Shaping the future of medicine through diverse therapeutic applications of tetralin derivatives

Bhumi M. Shah, Radhika N. Kachhadiya

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Review Article

Harmine and its derivatives: an In-depth review of antitumor mechanisms and structure-activity relationship

Taoufik Akabli, Hamid Toufik, Fatima Lamchouri

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Original Research Article

Design, synthesis, and evaluation of antitumor activity of quinazoline derivatives containing different terminal segments of basic amine groups

Shihao Wang, Zichen Yang, Dongling Gu, JiaHui Han, Hongjing Chen, Hao Wang, JiaXin Zheng, Hongmin Liu, Yu Ke, Qiurong Zhang

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Original Research Article

Esters and amides of benzofuroxan-1-N–oxide derivatives as trypanocidal and leishmanicidal agents

Alonzo González-González, Adriana Moreno-Rodríguez, Isidro Palos, Eyra Ortiz-Pérez, Alma D. Paz-Gonzalez, Gildardo Rivera

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Original Research Article

Synthesis of tetrahydro-β-carboline analogs with N11 modifications and study of their antimalarial activities

Deepak Kumar, Cherish Prashar, Vandana Vandana, Kailash C. Pandey, Dipti Vaya, Tejpal Singh Chundawat

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Original Research Article

Design, synthesis, molecular docking, and antibacterial activity of novel amide-linked tetrahydrobenzothienopyrimidinone derivatives as potential DNA gyrase and topoisomerase IV inhibitors

Mamdouh F. A. Mohamed, Ahmed M. Soliman, Omar Alshazly, Ayman Nafady, Razium Ali Soomro

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Original Research Article

Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment

Iman A. Y. Ghannam, Islam H. Ali, Rasha Z. Batran, Mahmoud T. Abo-elfadl, Rasha M. Allam, Ibrahim M. Ibrahim, Faten Farouk

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Original Research Article

Design of novel benzimidazole-propane hydrazide derivatives as α-glucosidase and α-amylase inhibitors: in vitro and in silico studies

Shiva Mohammadizadeh, Somaye Karimian, Navid Dastyafteh, Milad Noori, Fatemeh Doraghi, Maryam Mohammadi-Khanaposhtani, Bagher Larijani, Mohammad Mahdavi, Nastaran Sadeghian, Ayd?n Akta?, Parham Taslimi, ?lhami Gul?in

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Original Research Article

New derivatives of dipicolinic acid as metallo-β-lactamase NDM-1 inhibitors

Tatiana S. Shkuratova, Vitaly G. Grigorenko, Irina P. Andreeva, Valeria A. Litvinova, Natalia E. Grammatikova, Alexander S. Tikhomirov, Alexey M. Egorov, Andrey E. Shchekotikhin

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Original Research Article

Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities

Juan Zhang, Conghao Gai, Jing Wang, Xiaobin Zhuo, Yan Zou, Jishun Yang, Yan Song, Qingjie Zhao, Xiaoyun Chai

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Original Research Article

Synthesis and in vitro antiproliferative evaluation of novel drimane oxepinyl triazoles from labdane diterpene sclareol

Gulzar Hussain, Manzoor Ahmed, Sundas Chowdhary, Sanket K. Shukla, Syed Khalid Yousuf

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Original Research Article

Design, synthesis, stereochemical characterization, in vitro α-glucosidase, and α-amylase inhibition and in silico studies of novel pyrazole-hydrazide hydrazones

Issam Ameziane El Hassani, Salma Mortada, Njabulo J. Gumede, Hamza Assila, Ali Alsalme, Afaf Oulmidi, My El Abbes Faouzi, Khalid Karrouchi, M’hammed Ansar

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Original Research Article

Design, synthesis and investigating the in vitro and in silico HDAC8 inhibitory activities of derivatives of [6]-shogaol and [6]-gingerol isolated from ginger (Zingiber officinale)

Thitiporn Kamloon, Pattamabhorn Worsawat, Chanokbhorn Phaosiri, Chiwarat Romsanthia, Puttima Pimphoklang, La-or Somsakeesit, Thanaset Senawong, Gulsiri Senawong, Narissara Namwan, Nopawit Khamto, Puracheth Rithchumpon, Pakit Kumboonma

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