Med. Chem. Res. 2024, Vol 33, Iss 9

Medicinal Chemistry Research | 2024 | ?Volume 33, Issue 9, ?is now available online.

In this issue

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Review Article

In silico drug discovery: a machine learning-driven systematic review

Sema Atasever

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Review Article

Exploring the decadal evolution of indolizine scaffold for anticancer innovations: a comprehensive analysis

Madhav Jadhav, Kishori Mali, Vikash Rajput, Rudradip Das, Amit Shard

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Original Research Article

Novel monastrol/melatonin hybrids as a new approach for colorectal cancer intervention: design, synthesis, biological activity, and drug-likeness modeling studies

David Preciado-A, Andrés F. Yepes, Angie Herrera-R, Wilson Cardona-G

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Original Research Article

Design, synthesis and biological evaluation of potent thiazolidinedione salicylic acid inhibitors against glyoxalase-I as potential anticancer agents

Banan O. Alomari, Lara I. Fakhouri, Nizar A. Al?Shar’i, Qosay Albalas

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Original Research Article

ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine

Marat I. Kamalov, Andrey V. Nemtarev, Rezeda A. Ishkaeva, Kenana Dayob, Diana V. Salakhieva, Timur I. Abdullin

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Original Research Article

Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2

Aaminat Qureshi, Samina Bano

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Original Research Article

Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2

Ashish M. Kanhed, Amisha Vora, Ami Thakkar, Gudepalya Renukaiah Rudramurthy, Radha Krishan Shandil, Rajappa Harisha, Mayas Singh, Shridhar Narayanan

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Original Research Article

Ultrasound-assisted synthesis of 4-thiazolidinone Schiff bases and their antioxidant, α-glucosidase, α-amylase inhibition, mode of inhibition and computational studies

Pule Seboletswe, Gobind Kumar, Lungisani Kubone, Kolawole Olofinsan, Almahi Idris, Md. Shahidul Islam, Parvesh Singh

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Original Research Article

Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans

Yandan Wu, Luyi Jiang, Ruina Liu, Lijiao Yang, Fei Zou, Tianyu Zhang, Zefei Fan, Tianbao Zhang, Huan Yang, Shuyun Yin, Ruirui Wang, Ganpeng Li, Guanghui Ni

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Original Research Article

Identification of potential natural product derivatives as CK2 inhibitors based on GA-MLR QSAR modeling, synthesis and biological evaluation

Yanan Xuan, Yue Zhou, Yue Yue, Na Zhang, Guohui Sun, Tengjiao Fan, Lijiao Zhao, Rugang Zhong

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Original Research Article

Novel 2-[(8-hydroxyquinolin-7-yl)(phenyl)methylamino]benzoic acid analogs targeting the active site of botulinum neurotoxins: designing, synthesis, and biological evaluation

Surabhi Agnihotri, Vinita Chauhan Kushwah, Surabhi Bansal, Manorama Vimal, Nandita Saxena, Ram Kumar Dhaked

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Original Research Article

Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model

Buthaina Hussein, Mohammad Alwahsh, Yusuf Al-Hiari, Laurance Bourghli, Basmah Al-Jammal, Tareq Al-Qirim, Nader R. AlBujuq, Rania Abu-zaid, Fadi G. Saqallah, Lama Hamadneh

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Original Research Article

Synthesis and anti-leishmanial activities of uniflorol analogues

Paula da Silva Cardoso, Luana Budny Niero, Tiago Elias Allievi Frizon, Silvia DalBó, Anne Cécile Le Lamer, Nicolas Gouault, Patrícia de Aguiar Amaral, James W. Barlow

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Original Research Article

Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications

Wen Lu, Rujuta Ghorpade, Xiaoxiao Yang, William Leonard, Ladie Kimberly De La Cruz, Binghe Wang

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Original Research Article

Synthesis, in vitro activity, and molecular docking of caffeic acid and resveratrol derivatives against Alzheimer’s disease-related enzymes

Alberto Martínez

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Original Research Article

A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies

David Preciado, Wilson Cardona-Galeano, Angie Herrera-Ramírez, Andrés F. Yepes

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