Med. Chem. Res. 2024, Vol 33, Iss 8

Medicinal Chemistry Research | 2024 | ?Volume 33, Issue 8, ?is now available online.

Special Issue in Honor of Prof. Ronald T. Borchardt on the Occasion of His 80th Birthday and for His Many Contributions to Drug Discovery and Development

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In this issue

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Editorial

Ronald T. Borchardt: a pioneer in drug discovery and development

Michael S. Wolfe, Xiangming Guan, Binghe Wang, Siming Wang

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Commentary

Role of the Caco-2 cell culture model developed in Dr. Ronald T. Borchardt’s lab in modern drug research and development: a perspective from a practitioner

Ming Hu

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Comment

Peptide-based therapeutics: challenges and solutions

Aramis J. Pereira, Luana J. de Campos, Huihua Xing, Martin Conda-Sheridan

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Review Article

Glutathione transporter as a target for brain drug delivery

Xiangming Guan

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Review Article

Development of semisynthetic saponin immunostimulants

Di Bai, Hyunjung Kim, Pengfei Wang

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Review Article

The emergence of sulfo-click amidation in kinetic target-guided synthesis

Prakash T. Parvatkar, Roman Manetsch

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Review Article

Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development

Lingyun Yang, Zhengnan Yuan, Yongkuan Li, Shuyue Yang, Bingchen Yu

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Review Article

Amyloid-independent pathogenesis for Alzheimer’s disease: implications for drug design

Michael S. Wolfe

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Review Article

Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment

Jingyi Ma, Dalton W. Staler, Ram I. Mahato

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Review Article

Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus

Ryan L. Bassett, Giovanni Gallo, Kim-Phuong N. Le, Lucio R. Volino

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A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy

Srinivas Rao Mandalapu, Shanshan Hou, Steffen Jockusch, Zhiying Shan, Lanrong Bi

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Original Research Article

Characterization of the CO release properties of a common CO donor, CORM-401, in the context of its application in studying CO biology

Nicola Bauer, Qiyue Mao, Xiaoxiao Yang, Binghe Wang

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Original Research Article

Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria

Longqin Hu, Haifa Albanyan, Jeffrey Yang, Xiangduan Tan, Yiling Wang, Min Yang, Xiaodi Zhong, Michael D. Ward, Amrik Sahota

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Correction

Correction to: Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria

Longqin Hu, Haifa Albanyan, Jeffrey Yang, Xiangduan Tan, Yiling Wang, Min Yang, Xiaodi Zhong, Michael D. Ward, Amrik Sahota

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Original Research Article

Folate-conjugated organic CO prodrugs: Synthesis and CO release kinetic studies

Shameer M. Kondengadan, Shubham Bansal, Xiaoxiao Yang, Binghe Wang

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Original Research Article

A study of alkene disulfonoxylation

Shyam Sathyamoorthi, Steven P. Kelley

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Original Research Article

Reversible in-situ assembly of PROTACs using iminoboronate conjugation

Ce Yang, Yayun Xie, Xiaoxiao Yang, Jun Yin, Binghe Wang

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Original Research Article

Development of LC-MS/MS methods affording identification and measurement of active metabolites in rat and dog plasma after oral dosing of a penta-ethyl ester prodrug of diethylenetriamine pentaacetic acid

John R. Kagel, Michael Jay, William C. Zamboni

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Original Research Article

Development of an in vitro model of the neurovascular unit for BBB permeability-linked neuroactivity screening

Kelsey E. Lubin, Zhuangyan (Monica) Xu, James P. Sluka, Gregory T. Knipp

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