Med. Chem. Res. 2024, Vol 33, Iss 7

Medicinal Chemistry Research | 2024 | ?Volume 33, Issue 7, ?is now available online.

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In this issue

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Review Article

Current trends and future directions for the synthesis and pharmacological applications of 2-(2-cyanopyrrolidin-1-yl)-N-3-hydroxyadamantan-1-yl) acetamide (Gliptins)

Shaikh Yahya, Mohammad Usman Shaikh, Prathmesh Pramod Deshpande, Sangshetti Jaiprakash Navnath, Akram Choudhary, Nisha Sharma, Mohd Shafeeque, M. Shahar Yar

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Review Article

Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain

Vahid Alivirdiloo, Mobasher Hajiabbasi, Morad Kohandel Gargari, Homa Kohandel Gargari, Farhood Ghazi, Mahya Mohammadi, Fatemeh Rahimi, Ahmad Mobed, Amin mehra

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Review Article

New sirtuin modulators: their uncovering, pharmacophore, and implications in drug discovery

Pei-Ti Chen, Keng Yoon Yeong

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Review Article

Redefining the significance of quinoline containing compounds as potent VEGFR-2 inhibitors for cancer therapy

Jurnal Reang, Vinita Sharma, Vivek Yadav, Rajiv K. Tonk, Jaseela Majeed, Archana Sharma, Prabodh C. Sharma

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Review Article

Unlocking therapeutic potential: exploring indole scaffolds and their structural insights as pharmacophores in designing anti-breast cancer agents

Adithya Vinod, H. M. Chandra Mouli, Anupam Jana, Ramalingam Peraman

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Review Article

Advances in anticancer applications of platinum(II) complexes of dithiocarbamates

Saeed Ahmad

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Original Research Article

Discovering cholinesterase inhibitors from Chinese herbal medicine with deep learning models

Fulu Pan, Yang Liu, Zhiqiang Luo, Guopeng Wang, Xueyan Li, Huining Liu, Shuang Yu, Dongying Qi, Xinyu Wang, Xiaoyu Chai, Qianqian Wang, Renfang Yin, Yanli Pan

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Original Research Article

Synthesis and characterization of new tetrakisphosphonic acid derivatives as FPPS inhibitors and evaluation of their anti-osteoclastogenic potential for prevention of osteoporosis

A. M. A. Hassan, Marwa El-Hussieny, Naglaa F. El-Sayed, Marwa A. Fouad, Ewies F. Ewies, Manal Abdel Fattah Ezzat

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Original Research Article

Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300

Abdelrahman A. Abuelkhir, Mariam Omara, Yosra I. Nagy, Ahmed E. Gouda, Ahmed S. Attia, Abdelrahman S. Mayhoub, Mohamed Hagras

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Original Research Article

Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD

Zhengwei Liu, Xinjuan Li, Mengqi Huang, Zhenhui Su, Qiyao Zhang, Yuting Li, Yi Zhou, Lintao Yu, Wenmin Liu, Zhipei Sang

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Original Research Article

Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study

Fikret Türkan, Adnan Cetin, Przemys?aw Rozbicki, Ercan O?uz, Ewa Wolińska, Danuta Branowska

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Original Research Article

Gallic acid derived diarylpropanones exhibit synergistic antibacterial activities

Sneha Singh, Sana Khan, Alka Kurmi, Ranjana Das, Barsha Thapa, Poonam Rani, Feroz Khan, Dharmendra Saikia, Debabrata Chanda, Arvind Singh Negi

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Original Research Article

N-Benzyl, N-phenethyl and N-benzyloxybenzamide derivatives inhibit amyloid-beta (Aβ42) aggregation and mitigate Aβ42-induced neurotoxicity

Yusheng Zhao, Arash Shakeri, Ahmed A. Hefny, Praveen P. N. Rao

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Original Research Article

Docking-guided exploration of the anti-flt3 potential of isoindigo derivatives towards potential treatments of acute myeloid leukemia

Mazen Al Sulaibi, Jalal Zahra, Sanaa Bardaweel, Mustafa El Abadleh, Mutasem O. Taha

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