Med. Chem. Res. 2024, Vol 33, Iss 4

Medicinal Chemistry Research | 2024 | ?Volume 33, Issue 4, ?is now available online.

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In this issue

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Review Article

Evolution and challenges of opioids in pain management: Understanding mechanisms and exploring strategies for safer analgesics

Toluwalope Temitope Bakare, Henrietta Onyinye Uzoeto, Laywonmen Newon Gonlepa, Samuel Cosmas, Judith Nnedimkpa Ajima, Amarachukwu Vivian Arazu, Somtochukwu Precious Ezechukwu, Chizoba Maryann Didiugwu, Glory Omini Ibiang, Abayomi Gaius Osotuyi, Olanrewaju Ayodeji Durojaye

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Review Article

Motor and non-motor symptoms, drugs, and their mode of action in Parkinson’s disease (PD): a review

Nancy Saini, Neetu Singh, Navneet Kaur, Sonali Garg, Manvinder Kaur, Asim Kumar, Meenakshi Verma, Kishanpal Singh, Harvinder Singh Sohal

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Original Research Article

2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus

Clementina M. M. Santos, Carina Proen?a, Marisa Freitas, Alberto N. Araújo, Artur M. S. Silva, Eduarda Fernandes

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Original Research Article

Adenine derivatives as inhibitors of the casein kinase CK1delta enzyme

Andrea Spinaci, Catia Lambertucci, Cui Chang, Michela Buccioni, Gabriella Marucci, Eleonora Cescon, Stephanie Federico, Giampiero Spalluto, Diego Dal Ben, Rosaria Volpini

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Original Research Article

Design, synthesis, and biochemical and computational screening of novel oxindole derivatives as inhibitors of Aurora A kinase and SARS-CoV-2 spike/host ACE2 interaction

Donatus B. Eni, Joel Cassel, Cyril T. Namba-Nzanguim, Conrad V. Simoben, Ian Tietjen, Ravikumar Akunuri, Joseph M. Salvino, Fidele Ntie-Kang

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Original Research Article

Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis

Yedukondalu Nalli, Sahil Bharti, Tanzeeba Amin, Rohit Singh, Jayaprakash Behera, Sagar S. Bhayye, Yogesh P. Bharitkar, Anindya Goswami, Mahendra Kumar Verma

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Original Research Article

Evaluation of ortho-substituted Bis-Functionalized Triazoles as Tyrosinase Inhibitors: Modulating Dopamine Synthesis and Behavior in Zebrafish

Shainaz Landge, Jack Philp, Aikohi Ugboya, Isaac Graves, Emmanuel Fasusi, Kamari Jordan, Karelle Aiken, Vinoth Sittaramane

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Original Research Article

Synthesis, urease inhibitory and anticancer evaluation of glucosamine-sulfonylurea conjugates

Ghadeer A. R. Y. Suaifan, Mayadah Shehadeh, Dua’a Tahboub, Aya A. M. Mohammed, Michael D. Threadgill, Anand Gaurav, Majid Khan

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Original Research Article

Diffractaic acid and its ethers as anti-respiratory syncytial virus agents

Aleksandr S. Filimonov, Diana U. Ismangulova, Anastasia A. Diveikina, Nina I. Komarova, Olga A. Luzina, Anna A. Shtro, Anastasia V. Galochkina, Yulia V. Nikolaeva, Artem M. Klabukov, Vera Z. Krivitskaya, Nariman F. Salakhutdinov

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Original Research Article

Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents

Jie Wang, Chi Zhou, Bo Li, Huaqing Liu, Hui Zhang, Lei Liu

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