Med. Chem. Res. 2024, Vol 33, Iss 11

Medicinal Chemistry Research | 2024 | ?Volume 33, Issue 11, ?is now available online.

Special Issue in Honor of Professor Stephen Neidle for His Many Contributions to Cancer Research and DNA-Targeting Drug Discovery

In this issue

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Editorial

Professor Stephen Neidle: A pioneer in cancer research and DNA-targeting drug discovery

Shozeb Haider, Claudia Sissi

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Comment

Ethical aspects of innovative medical and medicinal sciences

Claudia Sissi, Manlio Palumbo

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Review Article

Structural insights into G-quadruplex binding by metal complexes: implications for drug design

Tayler D. Prieto Otoya, Kane T. McQuaid, Christine J. Cardin

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Review Article

Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy

David Monchaud

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Review Article

The versatile NDI-based compounds: emerging anticancer and antimicrobial agents

Beatrice Tosoni, Matteo Nadai, Alessio Maria Caramiello, Filippo Doria, Mauro Freccero, Sara N. Richter

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Review

Targeting RNA-protein interactions with small molecules: promise and therapeutic potential

Curran Rhodes, Sumirtha Balaratnam, Kamyar Yazdani, Srinath Seshadri, John S. Schneekloth

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Brief Report

The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements

Abeer F. R. Alanazi, Shozeb Haider, Gary N. Parkinson

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Brief Report

Contrasting effect of different crowding agents on pseudoknot RNA stability

Sagar Satpathi, Tamaki Endoh, Naoki Sugimoto

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Brief Report

Insights into computer-aided G-quadruplex prediction in the digital age

Pulakesh Pramanik, Santanu Bhattacharya

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Brief Report

Structure-based virtual screening and molecular dynamics simulations of FDA-approved drugs targeting MALAT1

Roberta Rocca, Stefano Alcaro, Anna Artese

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Original Research Article

A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication

Gianluca Novello, Andrea Dodaro, Silvia Menin, Chiara Cavastracci Strascia, Mattia Sturlese, Veronica Salmaso, Stefano Moro

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Original Research Article

Synthesis of new Michael acceptors with cinnamamide scaffold as potential anti-breast cancer agents: cytotoxicity and ADME in silico studies

Ruth P. Paulino, Rosemeire B. Alves, Heveline Silva, Rossimiriam P. de Freitas

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Original Research Article

CO prodrugs: a new scaffold of adamantane-fused norbornen-7-ones with tunable water solubility

Ce Yang, Xingyue Ji, G. S. Sainaga Jyothi Vaskuri, Xiaoxiao Yang, Wen Lu, Zhengnan Yuan, Dongning Liu, Siming Wang, Chalet Tan, Binghe Wang

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Original Research Article

Design, synthesis and biological evaluation of novel pyrimidine-phenylsulfonylfuroxan hybrids

Dongling Gu, Shihao Wang, Zichen Yang, Hongjing Chen, Jiahui Han, Lingling Chi, Fuqiang Yu, Hao Wang, Jiaxin Zheng, Peirong Zhao, Hongmin Liu, Yu Ke, Qiurong Zhang

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Original Research Article

Synthesis, enzyme inhibition and molecular docking studies of novel 1,2,4-oxadiazole thioether derivatives

Nevin Ar?kan ?lmez, Samir Abbas Ali Noma, Yunus Kaya, Bilgen Osman

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Original Research Article

Inhibition of SARS-CoV-2 replication in cells by G-quadruplex ligands

Dehua Luo, Chenxi Liu, Elishiba Muturi, Zhe Hu, Wei Hong, Chao Gao, Junhua Li, Hongping Wei, Dengguo Wei, Hang Yang

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