Med. Chem. Res. 2023, Vol 32, Iss 10

Medicinal Chemistry Research | 2023 | ?Volume 32, Issue 10, ?is now available online.

In this issue

Review Article

Progress on biphenyl derivatives as PD-1/PD-L1 inhibitors

Shurong Wang, Yuli Wang, Hong Yan

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Original Research

Design, synthesis and antitumor activity evaluation of 5-cyano-2,4,6-substituted pyrimidine derivatives containing acrylamide group

Fuqiang Yu, Lingling Chi, Hao Wang, Chao Gao, Honglin Dai, Limin Liu, Zhengjie Wang, Yu Ke, Hongmin Liu, Qiurong Zhang

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Original Article

Design, synthesis and antitumor activity evaluation of pyrimidine derivatives containing 4-hydroxypiperidine group

Lingling Chi, Hao Wang, Fuqiang Yu, Chao Gao, Honglin Dai, Limin Liu, Zhengjie Wang, Yuze Dong, Hongmin Liu, Qiurong Zhang

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Original Research

Design, synthesis and antitumor activity evaluation of tetrasubstituted pyrimidine derivatives containing methyl phenyl sulfone group

Chao Gao, Fuqiang Yu, Lingling Chi, Hao Wang, Honglin Dai, Xiaojie Si, Yuze Dong, Hongmin Liu, Qiurong Zhang

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Original Research Article

Design, synthesis and antitumor activity evaluation of 4,6,7-trisubstituted quinazoline derivatives containing benzothiazole moiety

Fuqiang Yu, Ying Xu, Hao Wang, Lingling Chi, Xiaojie Si, Chao Gao, Honglin Dai, Limin Liu, Zhengjie Wang, Yu Ke, Hongmin Liu, Qiurong Zhang

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Original Research Article

A new cadinane sesquiterpenoid from Eupatorium adenophorum and α-glycosidase and AChE inhibitory activities of a gossypetin acylglucoside

Minh Giang Phan, Ngoc Phuc Dong, Thi Viet Huong Do, Minh Trang Vu, Phuong Linh To, Nghia Vu Nguyen, Thi Thu Thuy Tran, Susumu Kawakami, Hideaki Otsuka

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Original Research Article

Design, synthesis and antitumor activity evaluation of 2,4,6-trisubstituted quinazoline derivatives containing piperidine moiety

Honglin Dai, Fuqiang Yu, Hao Wang, Lingling Chi, Chao Gao, Xiaojie Si, Yutong Zhang, Zhuo Qian, Peirong Zhao, Yingnan Zhu, Hongmin Liu, Qiurong Zhang

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Original Research Article

Discovery of deguelin derivatives in combination with fluconazole against drug-resistant Candida albicans

Biaoqi Liu, Youwei Wu, Dingmei Qin, Hairong Wang, Hongjie Chen, Yi Zhang, Weilie Xiao, Xiaoli Li, Ruirui Wang, Ruihan Zhang

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Original Research Article

Using molecular networking and docking to explore arginase inhibitors among Drimys brasiliensis chemical constituents

Léia da C. Mendes, Thais B. Vieira Dantas, Richele P. Severino, Larissa Ramos G. da Silva, Dulce H. F. de Souza, Quezia B. Cass, Suelem D. Ramalho, Paulo C. Vieira, Guilherme E. de Souza, Rafael V. C. Guido, Marie-Kathrin Urschel, Christian Kersten, Lorena R. F. de Sousa

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Original Research Article

Synthesis of amide warhead containing coumarin derivatives as potential pancreatic lipase inhibitors: in silico and in vitro evaluation for obesity treatment

Nisha Yadav, Atish T. Paul

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Original Research Article

Synthesis of 2-amino-4H-chromenes catalyst-free via sequential Knoevenagel-Michael reaction and evaluation of biological activity in tumor cells

Poliana Gomes de Abrantes, Paloma Gomes de Abrantes, Dami?o Alves dos Santos Silva, Renata Rodrigues Magalh?es, Paulo Bruno Norberto da Silva, Gardenia Carmen Gadelha Milit?o, Renata Priscila Barros de Menezes, Luciana Scotti, Marcus Tullius Scotti, Juliana Alves Vale

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Original Research Article

Structure activity relationship (SAR) driven design and discovery of WCK 5107 (Zidebactam): novel β-lactam enhancer, potent against multidrug-resistant gram-negative pathogens

Satish Bhavsar, Sanjeev Joshi, Shivaji Pawar, Laxmikant Pavase, Amit Mishra, Sunil Jadhav, Sanjay Dabhade, Abhijeet K. Kayastha, Ravindra Yeole, Prasad Deshpande, Sachin Bhagwat, Mahesh Patel

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Original Research Article

Synthesis of indole-based ferulic acid derivatives and in vitro evaluation of antiviral activity against SARS-CoV-2

Marina Mol S. A. Verzola, Daisymara Priscila de Almeida Marques, Elany Barbosa da Silva, Mateus Sá Magalh?es Serafim, Rafaela Salgado Ferreira, Pavla Fajtová, Markus Kohlhoff, Anthony John O’Donoghue, Vinícius Gon?alves Maltarollo, Jordana Grazziela Alves Coelho-dos-Reis, Renata Barbosa de Oliveira

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Correction

Correction: Stable isotope applications in drug development and the elucidation of mechanisms of drug metabolism

Rheem A. Totah, Allan E. Rettie

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