May, 2022 | Excedr Monthly Newsletter
Hello and good afternoon.
We're going to try something new here. Starting this May, We'll be publishing our monthly newsletter on LinkedIn. It's a roundup of all the content we create for our readers and anyone interested in learning more about science and business.
May's newsletter includes:
Startup resources:
Consumables and application resources:
Company and Product Reviews:
If there's anything you'd like to see covered in the future, let us know.
Legal disputes between co-founders and?business partners is an unfortunately common problem when there is a difference of opinion as to which direction the company should take. In this article, we review some of the ways you can handle co-founder disputes.?Read more.
At the initial phases of founding a startup, having a co-founder, or business partner, can seem like the best option. After all, having two massively invested individuals and two pairs of hands to share the work certainly seems to make the hardest growth phase more manageable.?Read more.
If you’ve recently started a new company with a co-founder, or multiple co-founders, splitting your company’s equity is one the first major decisions you’ll make as a founding team. There are many variables to consider when making this decision, and choosing wisely on how to split the equity can have significant positive outcomes later on.?Read more.
Are you a biotechnology or life sciences startup co-founder? Have you recently incorporated your early-stage startup? Like entrepreneurs in other industries, you may be deciding whether or not to incorporate your new company in your home state, or whether to research alternatives instead.?Read more.?
You may have heard of the?83(b) election?before, especially if you’re a startup founder starting a new business. That’s because the 83(b) election, also referred to as the Section 83(b) election, allows you to pay taxes on the total fair market value of your equity when it’s granted, rather than at the time of vesting, saving you money in the long run.?Read more.
Gene editing, also known as genome engineering, is a revolutionary technique that modifies DNA to treat disease and improve human health. Among such techniques is the CRISPR system, standing for clustered regularly interspaced short palindromic repeats.
?It is?composed of two components, one of them being?guide RNA, or gRNA, a?specific RNA sequence that recognizes the region of interest in the target DNA and binds with the Cas9 protein, directing it to the target site to perform the modification process.?Read more.
领英推荐
Plasmids?are small, circular, extrachromosomal, double-stranded DNA molecules, naturally found in bacterial species. However, their presence has also been found in some archaea and eukaryotes.
They are physically different from chromosomal DNA. All bacterial plasmids replicate on their own and contain an origin of replication (which controls the plasmid’s host range and copy number) and genes that contribute to the survival of bacteria, such as antibiotic resistance genes.?Read more.
Deoxyribonuclease (DNase)?is a class of nuclease enzymes that cleaves the DNA molecule. It breaks the phosphodiester bond formed between two nucleotides of dsDNA or ssDNA, by cleaving either at/on ends or between the nucleic acid strands.
The enzyme is encoded by two different DNase genes—different in length and number of exons—and thus, is of two types: DNase I and DNase II.?Read more.
Deoxynucleotide triphosphate (dNTP)?is a monomeric unit of DNA and formed by reducing ribonucleotides with the enzyme ribonucleotide reductase (RNR). It contains a nitrogen base, bound to deoxyribose sugar, and three phosphate groups attached to its 5’ carbon.?Read more.
Nucleic acids can be modified?at the polynucleotide level through many enzymatic reactions. It includes methylation of both DNA and RNA, glycosylation of DNA, and a nucleotide addition to DNA and RNA molecules at 3′-hydroxyl termini.?
Polynucleotide kinases (PNK) are one such DNA modification enzymes that add phosphate groups to nucleic acid molecules. They transfer the gamma phosphate group from adenosine triphosphate (ATP) to the 5’ hydroxyl termini of DNA or RNA. Additionally, they also perform phosphatase activities in some situations.?Read more.
Gel electrophoresis is one of the most common standard techniques used in labs to separate biomolecules, such as DNA, RNA, and proteins based on their size or molecular weight. It’s a simple, sensitive, and rapid analytical tool.
The electrophoresis of proteins is a standard laboratory technique in which charged proteins are transported through a gel matrix by passing an electric field through a solvent.?Read more.
The costs of equipping a new laboratory are high. Many founders look for ways to save money when they can, leaving more budget for other parts of their business. Surplus Solutions LLC helps equipment buyers and sellers in the life sciences industry acquire or sell lab equipment, and provides a wide range of services, including negotiation, purchasing at an effective cost, brokerage, and equipment auctions.?Read more.
Malvern Panalytical is an international manufacturer and supplier of scientific and industrial analytical equipment. It’s a part of Spectris PLC, a leading provider of high-tech instruments, software, and test equipment.?Read more.
Canaan, an early-stage venture capital firm, has raised around $6 billion over 12 funds in the past 33 years. The firm focuses its passion and experience on investing in visionaries with transformative ideas. They have offices on the West Coast as well as the East Coast, and their headquarters is based in San Francisco.
They specialize in providing funding at every stage to startups and companies working toward transforming the medtech, biopharma, digital media, life sciences, and therapeutics industry.?Read more.
Founded 150 years ago,?Shimadzu Corporation is a world leading equipment manufacturer in analytical instruments. Shimadzu is headquartered in Nishinokyo Kuwabara-cho, Nakagyo-ku, Kyoto, Japan, and has a worldwide network of customers.?Read more.
CEO L'OT ENTREPRISE
2 年Excdr good evening! How can you help African laboratories. We have a medical analysis and research laboratory. But also a platform for the sale of scientific equipment in Cameroon. How can you help us?. We need support. Thanks
Co-Founder Caravel Bio | Health Sector MBA
2 年So helpful!