MATER CELLS----Advances in Regenerative Medicine
Advances in Regenerative Medicine
Author: Dra.Mirta D'Ambra M.D.Chairman of the World Academy Medical Sciences in Argentina -Ministry of Health Buenos Aires University -Argentina
ABSTRACT Advances in regenerative medicine have been evident in the last years and this has been obtained due to the new knowledge related to stem cells, which use in the replacement therapy has given rise to a new age in medicine. To such effects, a literature review was carried out aimed at spreading its generalities and implementations, as well as everything related to the basic investigations carried out in this field and the main achievements obtained. The possibility of expansion and differentiation of such cells, allow to obtain enough quantitiy of them, which helps the development of cell therapy. Key words: stem cells, regenerative medicine, cell therapy.
On the other hand, new connections are established between the stem cells and cancer cells, which makes the study of these a good way to approach the knowledge and treatment of patients with cancer. Therefore, in the area of research in biomedicine, these cells are increasingly used as a source of cell therapy in people suffering from Parkinson's and Alzheimer's diseases, as well as diabetes mellitus and heart disease, among others. Stem cells have a series of properties that distinguish them from the rest of cells and give them the optimum characteristics for their use in regenerative medicine, among which are: the high rate of proliferation and clonal regeneration through symmetrical divisions (self-renewal) ) and its high degree of potentiality to differentiate into different cell types through asymmetric divisions (differentiation). Therefore, stem cells are classified as totipotent, pluripotent or multipotent, because they are capable of generating one or more differentiated cell types, and possess the capacity for self-renewal. In higher animals, these are classified into 2 groups: embryonic stem cells and organ-specific stem cells (adult
As it is well stated, cell therapy or regenerative medicine, as new
scientific discipline, supports its applicability in stem cells, which not only
they have the ability to self-renew,
but also to give origin to others, through
of a differentiation process, which has allowed to regenerate damaged tissues and
stimulate angiogenesis.
Basic and clinical research conducted in recent years on cells
mother and her therapeutic possibilities have constituted "a revolution in medicine regenerative ".
Adult stem cells have marked a new stage of possibilities for the
regenerative medicine. These are present in most tissues and
can be mobilized with the application of colony stimulating factors
granulocytes, for subsequent collection by proven methods.
Its advantages are sustained and the evidence that demonstrates its
plasticity, so many recognize them as pluripotent.Obtaining them
autologo frees the procedure of its negative bioethical implications, meanwhile,
enables the opening of new therapeutic approaches.
CONCLUSION
The possibility of expansion and differentiation of said cells allows obtaining a
enough of these, which helps the development of cell therapy.
BIBLIOGRAPHIC REFERENCES
1. Doss MX, Koehler CI, Gissel C, Hescheler J, Sachinidis A. Embryonic stem cells: a
promising tool for cell replacement therapy J Cell Mol Med. 2004; 8 (4): 465-73.
2. Mata Miranda MM, Sánchez Monroy V, Vázquez Zapién GJ. Basic investigation
with pluripotent stem cells in the military medical school. Rev Sanit Mil. 2014;
68 (4): 233-7.
3. Arribas García de León MI. Differential plasticity of different cell clones
mesenchymal stem isolated from human lipoaspirados [Doctoral Thesis].
Institute of Bioengineering. Miguel Hernández University, 2010 [cited 18 Oct
2013].
4. Mato Matute E. Stem cells: a new concept of regenerative medicine. Rev
Cuban Endocrinol. 2004 [cited 18 Oct 2013]; 15 (2).
5. Brignier AC, Gewirtz AM. Embryonic and adult stem cell therapy. J Allergy Clin
3. Arribas García de León MI. Differential plasticity of different cell clones
mesenchymal stem isolated from human lipoaspirados [Doctoral Thesis].
Institute of Bioengineering. Miguel Hernández University, 2010 [cited 18 Oct
2013].
4. Mato Matute E. Stem cells: a new concept of regenerative medicine. Rev
Cuban Endocrinol 2004 [cited 18 Oct 2013]; 15 (2).
5. Brignier AC, Gewirtz AM. Embryonic and adult stem cell therapy. J Allergy Clin