Making CAR-T cells in vivo with mRNA
Image courtesy: In-Vivo Induced CAR-T Cell for the Potential Breakthrough to Overcome the Barriers of Current CAR-T Cell Therapy. Front. Oncol., 10 February 2022. Sec. Cancer Immunity and Immunotherapy. Volume 12 - 2022 | https://doi.org/10.3389/fon

Making CAR-T cells in vivo with mRNA

While these strides in CAR-T therapies are exciting for solid tumors (see MD Anderson article – What’s new in CAR-T cell therapy) - leveraging mRNA platform to create in-vivo CAR-T will be truly disruptive. Check this out?https://lnkd.in/eNBDznWD?- wherein researchers at UPenn induced in-vivo creation of CAR-T using mRNA encapsulated in LNP (Lipid NanoParticles). This approach could address in-vitro manufacturing challenges faced by CAR-T, potentially even address CRS and ICANs issues. If the mRNA is based on mapping of neo-antigens expressed by cancer cells this approach might also address potential immune editing by tumor cells. Exciting times ahead across many therapeutic areas!

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