Magnetism for mechanobiology and related biomedical applications
Our perspective article, titled "Magnetism for Mechanobiology and Related Biomedical Applications," has been published in Physical Review Applied. The integration of magnetism and biology offers exciting and transformative opportunities for advancing fundamental research in mechanobiology and developing novel biomedical applications.
This article explores how magnetic particles dispersed among living cells, when exposed to a variable magnetic field, can mechanically stimulate the cells and elicit physiological responses. Studies have demonstrated that low-frequency mechanical stimulation (a few Hz) can induce apoptosis in cancer cells and stimulate insulin secretion from pancreatic cells. In the field of neurology, ongoing research investigates the potential of magneto-mechanical stimulation to combat neurodegenerative diseases.
A notable advantage of this magneto-mechanical approach is its capacity to remotely modulate mechanical stress on cells by adjusting the applied magnetic field, enabling cell-type-specific effects.
This interdisciplinary field combines expertise from physics, biology (especially mechanobiology) and medicine to optimize magnetic tools, deepen understanding of cellular responses, and assess the safety and efficacy of magneto-mechanical stimulation in in-vivo models and humans. Magneto-mechanical stimulation of cells holds huge promise but progress are still needed to realize its full potential in real-world medical applications.
Access to article:
DOI: 10.1103/PhysRevApplied.23.010501
Hi Bernard. i never heard of this kind of research but i think it is very innovative and hopefully helps to better understand cells working and potential treatment of certain diseases. great!
Chief Scientist chez Spintec CEA/Grenoble
1 个月Thank you very much Daniele. We recently got very exciting results on organoids and tumoroids of healthy and cancerous pancreatic cells which give us further confirmation of the outstanding potential of magneto-mechanical stimulation of cells to fight cancers.
Staff Researcher at IPCMS now Visiting at Complutense Madrid
1 个月Congratulations for this work Bernard. I hope your research will, in the near future, introduce a transformative pathway to a real use of those tiny magnetic disks.
Dr., Researcher | Material science | Physics
1 个月very interesting results! Congratulations?
Professor at Babes Bolyai University of Cluj Napoca, Faculty of Physics, Department of Solid State Physics and Advanced Technologies
1 个月Fellicitations Bernard!