Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
Abdulkader Rahmo
President & CSO at SMSbiotech Regenerative Medicine All comments or posts represent my private opinions not necessarily that of SMSbiotech
by: Zeeshan Sheikh ?,*, Patricia J. Brooks ?, Oriyah Barzilay, Noah Fine and Michael Glogauer
The focus of the attached review article below, is on the interactions of macrophages and foreign body giant cells with biomaterial surfaces, and the physical, chemical and morphological characteristics of biomaterial surfaces that play a role in regulating the foreign body response. Events in the foreign body response include protein adsorption, adhesion of monocytes/macrophages, fusion to form FBGCs, and the consequent modification of the biomaterial surface. The effect of physico-chemical cues on macrophages is not well known and there is a complex interplay between biomaterial properties and those that result from interactions with the local environment. By having a better understanding of the role of macrophages in the tissue healing processes, especially in events that follow biomaterial implantation, we can design novel biomaterials-based tissue-engineered constructs that elicit a favorable immune response upon implantation and perform for their intended applications.
BSc Pharmacy, MSc, PhD. Clinical Chemistry
9 年Dear Dr. Abdukader We should thank you for this reference
Head of the Department of Experimental Surgery; Universit?tsklinikum Knappschaftskrankenhaus Bochum GmbH
9 年Dear Abdulkader, Thanks for this reference. Really helpful, informative for my groups' current work. Best regards