M101, the Hemoglobin from the Sea: History and Therapeutic Perspectives

Franck Zal,?Eric Delpy?and?Jonathan S. Jahr

Abstract

Oxygen is indispensable for the existence and maintenance of life as it is vital for life-sustaining aerobic respiration in Humans. Hemoglobin is the molecule which is responsible for carrying almost all of the oxygen in the blood. We report the discovery of a natural extracellular hemoglobin (M101) isolated from the polychaete?Arenicola marina. Its extraordinary properties make it a new therapeutic hope for providing efficient tissue oxygenation in different clinical situations. In particular, it is an ideal molecule for organ preservation before transplantation; preclinical and clinical studies have demonstrated the safety of M101 as an additive to organ preservation solutions and its beneficial effect on ischemia/reperfusion injuries. M101 applications are numerous and almost limitless, acting potentially at all places where oxygen is needed or missing.

https://link.springer.com/chapter/10.1007/978-3-030-95975-3_34