Life in 3D - Gelomics Newsletter September 2024
?? Welcome to our September newsletter! ??
This month, we’re excited to share our latest whitepaper: A Comprehensive Comparison to Matrigel?, highlighting the groundbreaking innovations of our LunaGel? 3D Tissue Culture System, an advanced alternative to Matrigel?. We also celebrate our finalist nomination in the 2024 Lord Mayor’s Business Awards. Dive in for more!
LunaGel? 3D Tissue Culture - A Comprehensive Comparison To Matrigel?
Enhanced Tunability, Reproducibility, and Biological Relevance for Advanced Research Applications
LunaGel? 3D Tissue Culture System offers a significant improvement over Matrigel? for 3D cell cultures, providing enhanced tunability, reproducibility, and biological relevance. Unlike Matrigel?, which has batch variability and undefined composition, LunaGel? enables precise control over ECM stiffness, supporting a wide range of tissue types and delivering consistent results. It is easy to handle, scalable, and accelerates workflows. LunaGel? is particularly suited for advanced research applications in cancer biology, drug development, and tissue engineering, offering a superior platform for replicating physiological and pathological conditions, ultimately leading to more reliable and predictive experimental outcomes.
This makes LunaGel? an advanced alternative for researchers seeking a more customizable and reliable 3D tissue culture system.
LunaGel? supports superior capillary-like network formation and maturation compared to Matrigel?. Representative confocal images of HUVEC/MSC co-cultures in Matrigel? and LunaGel? on days 3, 5, and 7. In LunaGel?, well-formed capillary-like networks stained for CD31 (red) and actin (green) develop early and mature over time, while in Matrigel?, networks are less organized and sparse. Nuclei are stained with DAPI (blue). Scale bar: 100 μm.
LunaGel? outperforms Matrigel? in Supporting MCF-7 Spheroid Formation, Metabolic Activity, and Proliferation. (A)Confocal images of MCF-7 spheroids cultured in Matrigel? and LunaGel? for 7 and 14 days. LunaGel? supports consistent, well-formed spheroids, while Matrigel? results in inconsistent spheroid morphology.
(B) Quantification of metabolic activity (left) and DNA content (right) at days 1 and 7. LunaGel? shows significantly higher and more consistent metabolic activity and cell proliferation compared to Matrigel? (mean ± SD, p < 0.01, *p < 0.001).
Gelomics has been named a finalist in the Accenture Australia Product Innovation Award at Lord Mayor's Business Awards 2024
This recognition as a finalist is a testament to our team's hard work and commitment to excellence in the international health sector. We are incredibly proud to be celebrated alongside other outstanding finalists who are pushing the boundaries of what is possible in exporting.
Read more here.
At Gelomics, we believe in providing our interns with genuine, hands-on experiences that bridge the gap between academic learning and real-world application
James Clayton is a QUT (Queensland University of Technology) student studying a dual degree of Biomedical Science and Business, majoring in Biotechnology and Marketing. While interning with us, he was given the chance to run a creative workshop with the Gelomics team. This workshop explored and deepened our understanding of Gelomics' mission and values. James's involvement allowed him to engage directly with our core values and witness firsthand how these principles are embedded in our daily operations and workplace culture.
Revolutionise your research with the LunaGel? 3D Tissue Culture System
Sign up for our 4-week free demo and discover the transformative potential of the LunaGel? ECM system for yourself.
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Experience the future of biomedical research today: https://www.gelomics.com/book-demo
The Latest 3D Cell Culture Papers
This paper investigates the water status in gelatin methacrylate (GelMA) hydrogels using two techniques: water relaxometry and differential scanning calorimetry (DSC). Water relaxometry assesses the molecular mobility of water within the hydrogel network, while DSC evaluates the thermal properties of water in different hydration states. The study reveals distinct populations of bound, intermediate, and free water within the hydrogel structure, providing insights into the interactions between water and the polymer network. These findings enhance the understanding of water dynamics in GelMA hydrogels, which is critical for optimizing their use in biomedical applications like tissue engineering and drug delivery.
This paper presents a novel high-throughput system, Oli-Up, for cultivating hypoxic 3D hydrogel cell cultures. Designed for parallel culture of 48 miniaturized hydrogels, the system allows precise oxygen control to mimic physiological conditions. The researchers used GelMA-encapsulated mesenchymal stem cells (MSCs) as a proof-of-concept, demonstrating hypoxia-induced cellular responses such as altered glucose metabolism and increased VEGF secretion. The system's scalability and compatibility with automation make it suitable for high-throughput applications like drug screening and personalized medicine.
View Whitepaper: LunaGel? Ultrapure GelMA Photocrosslinkable Extracellular Matrix
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5 个月This scientific research brings an excellent inside on this important topic!