Let's Dive Into the World of Nanovis!

We recently discussed our most frequently asked questions about our technology, and we've received so much feedback that we wanted to continue the conversation and really explore the world of Nanovis and our surface technology.

The Four Pillars of Nanotechnology Success

Nanotechnology is an engineered solution to several overlapping issues: implant colonization by bacteria, inflammation around the implant, vascularization after implantation, and osseointegration. Optimized solutions for one issue may not solve other problems. Nanovis has successfully engineered our nanoVIS Ti? surface technology to optimize the full process of implant integration from implantation to the end goal of osseointegration.

1. Bacterial Contamination Poses a Threat to All Implants1?3

• Reduces bacterial colonization
• nanoVIS Ti? reduces biofilm formation and spreading

2. Improves Inflammatory Response????

• Increased protein attachment allows lower immune response
• Nanovis surface technology decreases inflammatory cell attachment and activation while it encourages pro-healing macrophages

3. Increases Vascularization????

• Nanotubes speeds up the vascular ongrowth after implantation
• Vasculature supports new bone growth and accelerates healing

4. Accelerates Osseointegration??1?

A Look at the Team!

Our company culture and our team make us who we are and drive our success each and every day! Get to know some of our team members and see what really sets us apart from others.

Want to learn more about our surface technology and our team? Get the latest every month in the Nanovis Newsletter. Don't forget to subscribe to be the first when our next edition is live.

References:

1. Detwiler, D. et al., Reduced Bacterial Adhesion to nanoVIS Ti? Surface Technology, (https://nanovistechnology.com/images/PDFS/NAN-White-Paper-Volume-2.pdf).
2. Detwiler, D. et al., nanoVIS Ti? Surface Technology Decreases Biofilm Formation In Vivo, (https://nanovistechnology.com/images/PDFS/NAN-BiofilmWhitepaper-V3.pdf, 2024).
3. Ercan, B., Taylor, E., Alpaslan, E. & Webster, T. J. Diameter of titanium nanotubes influences anti-bacterial efficacy. Nanotechnology 22, 295102 (2011).
4. Chamberlain, L. Macrophage Inflammatory Response to TiO2 Nanotube Surfaces., doi:10.4236/jbnb.2011.23036 (2011).
5. Yu, W. P. et al. Titanium dioxide nanotubes promote M2 polarization by inhibiting macrophage glycolysis and ultimately accelerate endothelialization. Immun Inflamm Dis 9, 746-757, doi:10.1002/iid3.429 (2021).
6. Beltrán-Partida, E. et al. Improved in vitro angiogenic behavior on anodized titanium dioxide nanotubes. J Nanobiotechnology 15, 10, doi:10.1186/s12951-017-0247-8 (2017).
7. Khosravi, N., Maeda, A., DaCosta, R. S. & Davies, J. E. Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis. Commun Biol 1, 72, doi:10.1038/s42003-018-0074-y (2018).
8. Oh, S. et al. Stem cell fate dictated solely by altered nanotube dimension. Proc Natl Acad Sci U S A 106, 2130-2135, doi:10.1073/pnas.0813200106 (2009).
9. Ding, X. et al. The effects of hierarchical micro/nanosurfaces decorated with TiO2 nanotubes on the bioactivity of titanium implants in vitro and in vivo. International Journal of Nanomedicine 10, 19 (2015).
10. Wang, N. et al. Effects of TiO2 nanotubes with different diameters on gene expression and osseointegration of implants in minipigs. Biomaterials 32, 6900-6911, doi:https://dx.doi.org/10.1016/j.biomaterials.2011.06.023 (2011).