Leading Together: In a highly complex field, true healthcare transformation must come from within.

Healthcare has reached its Promethean Moment. In recent months, we've seen how an unprecedented surge of new tools and new perspectives are deviating so significantly from what has come before that a complete transformation that we knew was always needed is now also very possible. The unique challenges and opportunities afforded by new tools such as Large Language Models (LLMs) and other AI-powered automation tools were hardly imaginable when many of today’s clinicians began their careers in medicine and were still highly unlikely in healthcare even 12 months ago. The pace of innovation and scale from these tools can at times feel overwhelming and overly complex for many in the field, but it is our responsibility as healers and innovators to relentlessly pursue new ideas that offer more cures, more hope, more comfort, more health, and better outcomes equitably for more people.

We now face a once-in-a-lifetime opportunity to shape healthcare history, and it will require all of us in healthcare to embrace it and embrace healthcare transformation. At Mayo Clinic, we are pushing this transformation forward by leveraging strategic collaborations, platform-based partnerships, and coalitions with partners that share our same purpose and values. We are reaching across sectors and leveraging a diverse subset of experts to harness a robust, interconnected network of collaborators. By pulling in the expertise of cross-sector researchers and innovators, educators, patients and advocacy groups, coalitions and clinicians, Mayo Clinic is supporting a Platform model of care that is built to propel healthcare transformation forward.

Cross-Sector Research and Innovation

Mayo Clinic has remained a values-based organization since its inception, with teamwork as a founding value that emphasizes the importance of collaboration and valuing the contributions of others in all we do.

While Mayo Clinic is committed to leading healthcare transformation, we know that we cannot do it alone. True transformation requires working in concert with partners across the health sector and across sectors to accelerate the pace of discoveries and to bring new technologies and treatments to patients faster.

Below are several of our cross-sector research and innovation collaborations that are programmatically part of a larger network of collaborators, all supporting efforts to transform healthcare as we know it:?

Advanced Care at Home

Recognizing an increased need for acute care and recovery options in the home during and following the pandemic, Mayo Clinic created a partnership with Medically Home . Patients expect and deserve high-quality care and excellent outcomes in a convenient and comfortable setting, and in tandem with Kaiser Permanente and now many others, Mayo Clinic has helped build Medically Home’s virtual and physical care delivery model. The number of patients cared for in this model continues to grow.

Since its inception, more than 25,000 patients have benefited from the program, with very high patient and family satisfaction, with 50% lower 30-day hospital readmission rates than within a traditional hospital practice and now a lower cost of care. By shifting the standard of care to focus more on best meeting a patient’s distinct needs, no matter where they are, patients are experiencing better outcomes and avoiding hospital visits.

Device development

Mayo Clinic and 波科 are collaborating to develop new devices and technologies that address unmet patient needs, particularly to meet the growing need for innovative medical devices for aging patients who require more intensive care. Together, we have launched more clinical trials to improve patient outcomes faster than each of us would have on our own.

Motion Medical represents our joint strategic program, focused on accelerating the development of new treatments for various health conditions that affect both the quality and duration of life. Together, our ongoing projects are working to advance cures across interventional cardiology, oncology, neurology, and urology.

New and Evolving Collaborations to Support LLMs

Few organizations have the total expertise and resources to generate an LLM themselves, and this is especially true in healthcare where the delivery of correct unbiased information is an absolute imperative. While mindful of pitfalls, we can see the tangible benefit these tools will have for patients and providers alike, creating a clear need for more strategic collaborations across sectors with tech experts specialized in deep learning algorithms such as 谷歌 and other organizations.

While LLMs and other generative AI tools will not be a panacea to every challenge in healthcare, they are promising tools for supporting total healthcare transformation. This is why Mayo Clinic continues to prioritize new and evolving collaborations with like-minded academic and tech organizations that will help us integrate LLM and generative solutions for better, more complete care for patients.

We know that taking full advantage of these innovative new tools will not be possible unless we transition from a pipeline to a platform model of care.

Platform-based Partnerships

To truly stimulate a shift in healthcare, there must be a larger change in our thinking. We must transition from a traditional, linear pipeline-service-model thinking to a platform approach, which is built around secure, collective resources that support end-to-end solutions backed by data in a Distributed Data Network.

Unlike a pipeline model, a platform approach breaks down siloes and is purposefully collaborative and fuels innovation and access instead of limiting it. Realizing the need to build this from the ground up, we created the Mayo Clinic Platform to specifically address this urgent need for a new paradigm in healthcare.

With data as its foundation, a platform gains strength and efficacy through collaboration – fueling existing partnerships and sparking new collaborations. More data, and more data sharing, are allowing us to achieve better outcomes for all patients.?

Platform_Connect

Through its Distributed Data Network, Platform_Connect, Mayo Clinic Platform has created a first-of-its-kind global alliance spanning three continents. Mercy , Hospital Israelita Albert Einstein in Brazil, Sheba Medical Center, Tel Hashomer in Israel and University Health Network (UHN) in Canada are founding members of the Platform's data-sharing network and each brings unique strengths to the table. Through our alliance, a Data Behind Glass architecture allows each organization to benefit from an extensive set of AI-powered tools and de-identified data without risking proprietary or sensitive information.

With a wide range of demographical areas represented, new and diverse deidentified patient data are accelerating new AI-based solutions and creating better treatment recommendations for patients. It is our hope that the work of this alliance serves as inspiration that a platform model is not only possible – it is a highly effective, dynamic, and resilient system for patients and their providers.

Platform_Accelerate

Health tech startups are one of the key drivers of life-changing discoveries and breakthroughs. Mayo Clinic Platform created the Mayo Clinic Platform_Accelerate program to help early-stage health tech startups go from proof-of-concept to market-ready. By equipping these startups with resources and access to Mayo Clinic's rich, de-identified data sets, validation frameworks, and clinical workflow planning, they are solving complex healthcare challenges with tangible solutions.

For example, Platform_Accelerate graduate and startup company Predicta Med is developing a decision-support platform aimed at early detection and intervention recommendations for immune-related illnesses. Through the Platform_Accelerate program, more than 20 startups have developed and validated their AI-driven healthcare products and solutions.

Each of these collaborations helps to fill a critical niche toward healthcare transformation, yet we must also turn to educators to empower future healthcare leaders to be platform thinkers and practitioners.

Education

The next generation of healthcare innovators is sitting in today's university classrooms across the world. Collaborating with academic institutions creates a mutually beneficial relationship, giving hands-on experience to learners while helping to solve today’s healthcare challenges. Mayo Clinic partners with a variety of academic institutions across areas of diverse specialties to advance research and discover more cures, while also integrating the concept of Platform-thinking more broadly.

Mayo Clinic & Illinois Alliance

The Mayo Clinic and Illinois Alliance for Technology-Based Healthcare was organized more than a decade ago to train next-generation clinicians and biomedical scientists, pursue joint research opportunities, and deploy educational and research outcomes more broadly.

Since its inception, investigators have worked together to identify global challenges and create solutions together, exploring:

• Using a patient’s DNA sequence to aid the design and manufacture of new drugs for diseases;
• Personalized nutrition programs informed by smart devices and analytics;
• The use of Augmented Human Intelligence (AHI) to develop clinical decision-support tools to guide therapy in Major Depressive Disorder;
• New forms of brain imaging to expand the availability of tests to monitor the progression of disease in Alzheimer's patients and more

The Alliance has also helped to prepare more than 100 trainees for careers in biomedical research, paving the wave for future contributions to the field.

Arizona State University

United by a shared goal of expediting research breakthroughs, revolutionizing patient care, and reshaping medical education, Mayo Clinic’s strategic collaboration with 美国亚利桑那州立大学 is finding solutions for complex issues and serving as a catalyst for healthcare transformation.

The Health Futures Center in Phoenix is the hub for the Mayo Clinic and ASU Alliance for Health Care, born out of an ongoing collaboration between our two organizations that spans two decades.

Through a seed grant program, investigators from the Mayo Clinic and ASU Alliance for Health Care are researching:

• The use of machine learning to predict and manage postprandial hyperglycemia;
• 3D printing-enabled regenerative medicine for pelvic organ prolapse treatment;
• The engineering of targeted strategies to diagnose and treat endometriosis

Coalitions and Advocacy Groups

Innovation and transformative ideas in healthcare are not solutions in themselves – they also require rigorous frameworks and guidelines that ensure the responsible and equitable use of new and emerging technologies and tools. Working together to harmonize standards for new technologies, innovative care models, and digital tools creates a more viable and vibrant innovation ecosystem for all, and long-lasting, sustainable solutions for patients.

Mayo Clinic is a founding member and stakeholder of coalitions that are advocating for the implementation of guidelines and parameters in some of our key priority areas, bringing together like-minded change agents for the betterment of all of healthcare:

Coalition for Health AI

The Coalition for Health AI (CHAI) was established to address the need for more guidelines surrounding the responsible use of AI in healthcare. Mayo Clinic is a founding member of the coalition, alongside academic health systems, organizations, and expert practitioners of AI and data science. We are working together to create a much-needed blueprint that ensures AI systems are credible, fair, and transparent.

I am also co-chairing a three-year National Academy of Medicine project alongside industry experts Roy Jakobs and Bakul Patel to develop a framework for a AI Code of Conduct as an additional effort to ensure the equitable and responsible use of AI in healthcare.

The Advanced Care at Home Coalition

With the increased need for more care and recovery options in the home, alongside other virtual models of care, Mayo Clinic, Kaiser Permanente, and Medically Home founded a coalition to advocate for the expansion of these new care models.

Joined by leading health systems and organizations, The Advanced Care at Home Coalition (ACH Coalition) has created a collective voice to advocate for the future of advanced care at home services. The coalition is focusing on ensuring these services are accessible, safe, high quality, equitable, and innovative.

Simultaneously, the coalition is actively engaged in enhancing the understanding of these benefits to the Centers for Medicare & Medicaid Services (CMS) and lawmakers to ensure these programs are widely known as critical components to shaping the future landscape of our healthcare system.

Coalition for Advancing Clinical Trials at the Point of Care

Mayo Clinic and several health organizations launched the Advancing Clinical Trials at the Point of Care Coalition (ACT@POC) to advocate for a more inclusive and effective clinical trial enterprise that gives clinicians quality research evidence in real time to better evaluate treatments and therapeutics.

Knowing we need more data to advance cures, the coalition focuses on supporting the design of trials to increase participation and improve patient access, while prioritizing the importance of diverse trial patients and more effective data collection tools. Collectively, we can better address some of the largest obstacles in the clinical trials space.

Even as the speed and magnitude of new innovations in healthcare continue to increase, Mayo Clinic is committed to leading together toward a total healthcare transformation for patients, for ourselves, for our partners, and for all of healthcare. We cannot do so without key players who embrace change and a relentless pursuit of more cures for more people through a Platform model of care. This is the only way to achieve a healthier future for generations to come. ??