?? Latest Innovations in Brain Health Globally ??

Cambridge University Press & Assessment CAMBRIDGE ENTERPRISE LIMITED disclosed a system for treating a patient having a spinal cord injury. The devices may be configured for implantation at a number of sites in the patient's body, including the brain, spinal cord, nerves or limbs. The controller may be arranged to: process the inputs by decoding the inputs to determine an intended stimulation of nerves of the patient rostral of the position of the first device on the spinal cord; and produce stimulation signals that, when applied to the patient's spinal cord by the second device, produce said intended stimulation of the nerves of the patient. A method of treating spinal cord injury is also provided. Link

波科 Boston Scientific Neuromodulation Corporation disclosed system and method for selecting leadwire stimulation parameters includes a processor iteratively performing. Link

UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY disclosed a composition for preventing or treating Parkinson’s disease, the composition comprising shogaol and levodopa as active ingredients. The shogaol according to the present invention was found to ameliorate intestinal motility disorder induced by levodopa while maintaining the efficacy of levodopa when administered in combination with levodopa in an animal model with Parkinson’s disease. Link

Prof HDR Newton HOWARD Newton Howard invented the Quantum microBrain.

An implant device may comprise a plurality of fibers adapted to receive electrical signals, optical signals, or both electrical and optical signals from neural signals of the brain tissue and to transmit signals, to provide stimulation of the brain tissue, and a controller to receive signals, determine direct neural connections by analyzing waveforms and propagation delays of the received signals, recognize at least one dead or non-functional neuron and determine direct neural connections affected by the at least one dead or non-functional neuron, and forward neural signals around the at least one dead or non-functional neuron by recording the received signals from one side of the at least one dead or non-functional neuron and transmitting the recorded signals to stimulate an other side of the at least one dead or non-functional neuron. Link

Netherlands Institute for Neuroscience NEDERLANDS HERSEN INSTITUUT invented a computer-implemented method for mapping electrodes of a brain prosthesis for substituting a defective functional modality of a mammal with one or more electrode arrays for stimulation of and recording from a region of the brain of said mammal corresponding to a neural modality for which said functional modality is to be substituted, wherein automated mapping is combined with manual mapping. Link

UNIV NEW YORK & CANAERY INC invented a method of identification of an odorprint of a health state of a living organism can include monitoring the composition of volatile compounds emitted by the organism using the olfactory system of the service animal equipped with the brain machine interface. The method can include finding the specific signature of the bio-electronic nose signal responsible for identification of a volatile compound odorprint of a health state of an organism. The method can include applying machine learning techniques to multi-component bio-electronic nose signals. The method can include identifying specific volatile compounds or their ratios carrying information about a health state of an organism. Link

UNIV NEW YORK & CANAERY INC invented an odor training and detection system can include multiple service animals. Each service animal can be provided with a means by which neural activity can be read from the olfactory system. Each service animal can be associated with an edge computing device containing an updateable local database and enabled with wireless communication. Each service animal can be equipped with one or multiple cloud-based servers and databases. A family of anchor odor sets and computational methods can enable the alignment of olfactory maps across individual animals into a common coordinate framework. Further disclosed is a means of computing and communicating (in a privacy -preserving manner if desirable) federated updates to olfactory decoding models between the local databases on the edge and the cloud database(s). Link

ADEL INC invented an animal model in which social dominance is absent, and a pharmaceutical composition for preventing or treating diseases associated with the absence or reduction of social dominance. In an animal model, according to the present invention, social dominance is absent through inhibiting of the expression or activity of a CREB-regulated transcription coactivator 3 (CRTC3) gene or protein, and the animal model can be used as a model for diseases associated with the absence or reduction of social dominance. In addition, the present invention enables the prevention, alleviation or treatment of diseases associated with the absence or reduction of social dominance by using a composition containing agonists for brain epidermal growth factor (EGF) receptors. Link

UTI LP & UNIV ALBERTA invented a method of determining a likelihood of a favorable or unfavorable outcome, such as death or a Glasgow Outcome Scale Extended (GOSE) score ≤ 4, in a subject having severe traumatic brain injury (sTBI). The method involves quantitative assessment of multiple metabolites shortly after the injury, such as on day 1 and/or day 4 for changes indicative of outcome. Quantitative mass spectrometry (MS) or proton (1H) nuclear magnetic resonance spectroscopy (NMR) may be used to assess multiple metabolites within a single blood sample for comparison with a control. Link

CODAGENIX INC invented the deoptimized Yellow Fever viruses and their uses for the treatment of various forms of malignant tumors, and as vaccines against Yellow Fever. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, skin, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Link

EISAI R&D MAN CO LTD invented method of diagnosing, selecting, monitoring, and treating subjects with Alzheimer's disease (AD) or suspected of having AD or another disorder associated with amyloid accumulation in the brain. Link

UNIV DEVRY VAL D ESSONNE & CENTRE HOSPITALIER SUD FRANCILIEN invented an automatic method for the segmentation of a thrombus and a lesion caused by the thrombus in a three-dimensional brain image, said method comprising the following steps: - supervised training of at least one primary recurrent artificial neural network in order to provide a lesion prediction from an image; - supervised training of at least one secondary recurrent artificial neural network in order to provide a thrombus prediction from an image; - using each trained primary recurrent artificial neural network on each image of a set of images obtained from the three-dimensional image, and merging the lesion predictions obtained in order to obtain a set of lesion segmentations: o if the set of lesion segmentations comprises at least one segmentation, selecting the widest segmentation as the lesion segmentation; - using each trained secondary recurrent artificial neural network on each image of a set of secondary images obtained from the three-dimensional image, and merging the thrombus predictions obtained in order to obtain a set of thrombus segmentations: o if the set of thrombus segmentations comprises at least one segmentation, selecting, as the thrombus segmentation, the segmentation corresponding to a proximity condition dependent on the lesion segmentation. Link

Neumarker Inc. Neumarker, Inc invented a method and system for determining a treatment outcome prediction for a patient using electroencephalograph (EEG) are disclosed, which include analyzing a brain region mutual interaction characteristics using scalp EEG data from a patient and obtaining a set of brain region mutual interaction feature matrices, performing a feature enhancement process to the brain region mutual interaction feature matrices to extract prominent mutual interaction features and applying a treatment response predictive model to determine a treatment outcome prediction for the patient. Further disclosed is a method of generating a treatment response predictive model using EEG dataset of a group of patients under a clinical treatment. The method and system can be used for determining a treatment outcome prediction for a psychiatric disorder patient and a patient diagnosed with COVID-19 and suffering from psychiatric disorder symptom(s) originated from COVID-19. Link

Alekseev Aleksandr Olegovic et al., invented method to diagnose Alzheimer’s disease via magnetic resonance imaging with the introduction of a contrast agent. Link