The Latest and Greatest in CRISPR News, Content, Events, and More!
Your June CRISPR Newsletter
Welcome to the June newsletter! We're keeping you updated on all the happenings with Synthego, CRISPR, and genome engineering. Scroll down to check out the latest and greatest in product updates, educational content, and the best CRISPR news available.
The Tools that Enable Scientists to Alter Genetic Code
Since first being described as a genome editing tool in 2012, CRISPR-Cas9 has changed how we manipulate DNA in applications ranging from functional genomics and DNA imaging, to diagnostics and therapeutics. Genome editing techniques have since seen an explosion of advances leading to more accurate delivery methods, precision editing, and reduced off-target effects.?
Read this recently updated blog post to learn more about the basics of how genome editing works and the cutting-edge tools scientists are using to edit DNA.
Ensure You’re Using the Right Target Screening Technique
There are many different target identification techniques, but knowing which one to use in your research can be challenging. Older methodologies that rely on RNAi knockdowns or lentiviral vectors commonly result in inefficient gene silencing and random vector integration, leading to enormous limitations in your downstream workflow.
Arrayed CRISPR Screening Libraries enable the identification of true, genetically validated targets for ultimate downstream success.
In this webinar, you will learn about the pros and cons of RNAi vs. CRISPR screens, pooled vs. arrayed formats, and lentiviral vs. synthetic sgRNA. If arrayed synthetic sgRNA libraries are indeed a fit for your screens, you will also learn how to easily start using proprietary multi-guide technology – whether you want to knock out 1, 10, or even 1000s of genes.
Simplify Your Path to the Clinic
Moving into clinical development for your new CRISPR therapy? Synthego offers GMP-grade single guide RNA to support the workflow for your CRISPR cell and gene therapy. Our GMP-compliant facility encompasses a manufacturing system designed to meet all required quality standards and ensure you’re using the most advanced editing techniques.??
With more than 70 successful GMP campaigns, extensive CMC options for release testing and stability studies, and an expert quality team to aid you in your IND filings for your gene-modified cell therapies, Synthego simplifies your transition to the clinic.
Disease models allow scientists to generate physiologically relevant cell-based systems containing disease-causing or correlating mutations to further study the pathology of the condition. However, generating accurate disease models can be challenging. Using conventional methods, such as primary or stem cells, can be notoriously difficult.?
Synthego’s automated process for generating cell-based, preclinical disease models enables researchers to skip the technical challenges and use CRISPR to accelerate their research in a fraction of the time and cost it would take to do it themselves.?
Read our Disease Modeling App Note to learn more about the benefits of using CRISPR rather than spending the time doing CRISPR!